{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:36:51Z","timestamp":1790836611366,"version":"4.1.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"crossref","award":["THV-F20-142"],"award-info":[{"award-number":["THV-F20-142"]}],"id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"crossref"}]},{"name":"GERCA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TH Open"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Patients with atrial fibrillation (AF) are likely to have a poor prognosis including bleedings following transcatheter aortic valve replacement (TAVR). Closure time of adenosine diphosphate (CT-ADP) is a primary hemostasis point-of-care test and is a predictor of bleeding events following TAVR. We aimed to evaluate the impact of ongoing primary hemostatic disorders on bleeding events in TAVR patients with AF.<\/jats:p><jats:p>\n          Methods\u2003We enrolled 878 patients from our prospective registry. The primary endpoint was VARC-2 major\/life-threatening bleeding complications (MLBCs) at 1 year after TAVR and secondary endpoint was major adverse cardiac and cerebrovascular events (MACCEs) at 1 year, defined as a composite of all-cause death, myocardial infarction, stroke, and heart failure hospitalization. Ongoing primary hemostatic disorder was defined by a postprocedural CT-ADP &gt;180\u2009seconds.<\/jats:p><jats:p>\n          Results\u2003Patients with AF had a higher incidence of MLBCs (20 vs. 12%, p\u2009=\u20090.002), MACCE (29 vs. 20%, p\u2009=\u20090.002), and all-cause mortality (15 vs. 8%, p\u2009=\u20090.002) within 1 year compared to non-AF patients. When the cohort was split into four subgroups according to AF and CT-ADP &gt;180\u2009seconds, patients with AF and CT-ADP &gt;180\u2009seconds had the highest risk of MLBCs and MACCE. Multivariate Cox regression analysis confirmed that the patients with AF and CT-ADP &gt;180\u2009seconds had 3.9-fold higher risk of MLBCs, whereas those patients were no longer associated with MACCE after the adjustment.<\/jats:p><jats:p>\n          Conclusion\u2003In TAVR patients, AF with postprocedural CT-ADP &gt;180\u2009seconds was strongly associated with MLBCs following TAVR. Our study suggests that persistent primary hemostatic disorders contribute to a higher risk of bleeding events particularly in AF patients.<\/jats:p>","DOI":"10.1055\/a-2068-5783","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T23:23:35Z","timestamp":1680650615000},"page":"e117-e127","source":"Crossref","is-referenced-by-count":7,"title":["Combination of Primary Hemostatic Disorders and Atrial Fibrillation Increases Bleeding Events Following Transcatheter Aortic Valve Replacement"],"prefix":"10.1055","volume":"07","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-2921","authenticated-orcid":false,"given":"Kensuke","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Strasbourg, France"},{"name":"UMR1260 INSERM, Nanom\u00e9decine R\u00e9g\u00e9n\u00e9rative, Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Marchandot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Kibler","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Carmona","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truong Dinh","family":"Phi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Heger","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonin","family":"Trimaille","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Hess","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Sattler","sequence":"additional","affiliation":[{"name":"Department of Haemostasis, Centre Hospitalier Universitaire, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickael","family":"Ohana","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Reydel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d'Activit\u00e9 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