{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:51:12Z","timestamp":1788997872208,"version":"build-2803163510"},"reference-count":527,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Das Management von Asthma hat sich in den letzten Jahrzehnten fundamental gewandelt. Die vorliegende Leitlinie zur Diagnostik und Therapie von Asthma wurde f\u00fcr pneumologisch t\u00e4tige Fach\u00e4rztinnen und Fach\u00e4rzte entwickelt, welche detaillierte und evidenzbasierte Informationen zu den neuen diagnostischen und therapeutischen Optionen von Asthma ben\u00f6tigen. Die Leitlinie zeigt die neue Bedeutung der Biomarker, insbesondere der Bluteosinophilen und des exhalierten NO (FeNO), in den diagnostischen Algorithmen von Asthma. Als erste Asthma-Leitlinie weltweit benennt die vorliegende Leitlinie die nachhaltige Symptompr\u00e4vention und die Asthma-Remission als Asthma-Therapieziele, welche durch den Einsatz individuell angepasster, krankheitsmodifizierender Medikamente (wie inhalative Steroide, Allergenimmuntherapie oder Biologika) erreicht werden k\u00f6nnen. Die zentrale Bedeutung der Behandlung von typischen Asthma-Komorbidit\u00e4ten wird zudem betont. Schlie\u00dflich wird auch auf besondere Herausforderungen im Asthma-Management eingegangen, wie bspw. die Therapie von Asthma in der Schwangerschaft, die Behandlung von schwerem Asthma oder die Diagnostik und Therapie von arbeitsbedingten Asthma-Formen.<\/jats:p>","DOI":"10.1055\/a-2070-2135","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T19:08:41Z","timestamp":1688584121000},"page":"461-543","source":"Crossref","is-referenced-by-count":64,"title":["S2k-Leitlinie zur fach\u00e4rztlichen Diagnostik und Therapie von Asthma 2023"],"prefix":"10.1055","volume":"77","author":[{"given":"Marek","family":"Lommatzsch","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Innere Medizin, Abt. f\u00fcr Pneumologie, Universit\u00e4tsmedizin Rostock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl-Peter","family":"Cri\u00e9e","sequence":"additional","affiliation":[{"name":"Praxis f\u00fcr Innere Medizin und Pneumologie, Northeim"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen C. 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