{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T19:03:58Z","timestamp":1781636638760,"version":"3.54.5"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"S 01","funder":[{"name":"National Institute of Health","award":["KL2 TR001426"],"award-info":[{"award-number":["KL2 TR001426"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003Magnetic resonance imaging (MRI) is the standard of care for evaluation of brain injury after hypoxic\u2013ischemic encephalopathy (HIE) in term newborns. This study utilizes diffusion tensor imaging (DTI) to (1) identify infants at highest risk of development of cerebral palsy (CP) following HIE and to (2) identify regions of the brain critical to normal fidgety general movements (GMs) at 3 to 4 months of postterm. Absence of these normal, physiological movements is highly predictive of CP.<\/jats:p><jats:p>\n            Study Design\u2003Term infants treated with hypothermia for HIE from January 2017 to December 2021 were consented for participation and had brain MRI with DTI after rewarming. The Prechtl's General Movements Assessment was performed at 12 to 16 weeks of age. Structural MRIs were reviewed for abnormalities, and DTI data were processed with the FMRIB Software Library. Infants underwent the Bayley Scales of Infant and Toddler Development III test at 24 months.<\/jats:p><jats:p>\n            Results\u2003Forty-five infant families were consented; three infants died prior to MRI and were excluded, and a fourth infant was excluded due to diagnosis of a neuromuscular disorder. Twenty-one infants were excluded due to major movement artifact on diffusion images. Ultimately, 17 infants with normal fidgety GMs were compared with 3 infants with absent fidgety GMs with similar maternal and infant characteristics. Infants with absent fidgety GMs had decreased fractional anisotropy of several important white matter tracts, including the posterior limb of the internal capsule, optic radiations, and corpus callosum (p\u2009&lt;\u20090.05). All three infants with absent fidgety GMs and two with normal GMs went on to be diagnosed with CP.<\/jats:p><jats:p>\n            Conclusion\u2003This study identifies white matter tracts of the brain critical to development of normal fidgety GMs in infants at 3 to 4 months of postterm using advanced MRI techniques. These findings identify those at highest risk for CP among infants with moderate\/severe HIE prior to hospital discharge.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2071-3057","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T23:28:25Z","timestamp":1681255705000},"page":"e1740-e1746","source":"Crossref","is-referenced-by-count":4,"special_numbering":"S","title":["Diffusion Tensor Imaging to Predict Neurodevelopmental Impairment in Infants after Hypoxic\u2013Ischemic Injury"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-2191","authenticated-orcid":false,"given":"Christa","family":"Tabacaru","sequence":"additional","affiliation":[{"name":"Department of Neonatal-Perinatal Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adebayo","family":"Braimah","sequence":"additional","affiliation":[{"name":"Department of Radiology, Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Kline-Fath","sequence":"additional","affiliation":[{"name":"Department of Radiology, Fetal and Neonatal Imaging, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Radiology, University of Cincinnati Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Neonatal-Perinatal Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Merhar","sequence":"additional","affiliation":[{"name":"Department of Neonatal-Perinatal Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"J J Kurinczuk","year":"2010","journal-title":"Early Hum Dev"},{"issue":"S 03","key":"ref2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/dmcn.12727","article-title":"The long-term health, social, and financial burden of hypoxic-ischaemic encephalopathy","volume":"57","author":"P Eunson","year":"2015","journal-title":"Dev Med Child Neurol"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/jamapediatrics.2017.1689","article-title":"Early accurate diagnosis and early intervention in cerebral palsy: advances in diagnosis and treatment","volume":"171","author":"I Novak","year":"2017","journal-title":"JAMA Pediatr"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/dmcn.13697","article-title":"Predictive validity of spontaneous early infant movement for later cerebral palsy: a systematic review","volume":"60","author":"A KL Kwong","year":"2018","journal-title":"Dev Med Child Neurol"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0006-8993(74)90454-5","article-title":"The behavioural states of the newborn infant (a review)","volume":"76","author":"H F Prechtl","year":"1974","journal-title":"Brain Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1016\/j.jped.2015.12.003","article-title":"Fidgety movements - tiny in appearance, but huge in impact","volume":"92","author":"C Einspieler","year":"2016","journal-title":"J Pediatr (Rio J)"},{"issue":"07","key":"ref7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/s00247-006-0164-8","article-title":"Magnetic resonance imaging in perinatal brain injury: clinical presentation, lesions and outcome","volume":"36","author":"M Rutherford","year":"2006","journal-title":"Pediatr Radiol"},{"issue":"07","key":"ref8","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s00247-006-0203-5","article-title":"Patterns of damage in the mature neonatal brain","volume":"36","author":"F Triulzi","year":"2006","journal-title":"Pediatr Radiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jpeds.2017.09.043","article-title":"A novel magnetic resonance imaging score predicts neurodevelopmental outcome after perinatal asphyxia and therapeutic hypothermia","volume":"192","author":"L C Weeke","year":"2018","journal-title":"J Pediatr"},{"issue":"01","key":"ref10","first-page":"143","article-title":"Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems","volume":"19","author":"A J Barkovich","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"issue":"06","key":"ref11","first-page":"F398","article-title":"Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy","volume":"97","author":"S Shankaran","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"07","key":"ref12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.earlhumdev.2013.03.014","article-title":"General movements and magnetic resonance imaging in the prediction of neuromotor outcome in children born extremely preterm","volume":"89","author":"B Ski\u00f6ld","year":"2013","journal-title":"Early Hum Dev"},{"issue":"10","key":"ref13","first-page":"1638","article-title":"An introduction to kurtosis fractional anisotropy","volume":"40","author":"B Hansen","year":"2019","journal-title":"AJNR Am J Neuroradiol"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"FSL","volume":"62","author":"M Jenkinson","year":"2012","journal-title":"Neuroimage"},{"issue":"05","key":"ref15","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/mrm.10609","article-title":"Characterization and propagation of uncertainty in diffusion-weighted MR imaging","volume":"50","author":"T E Behrens","year":"2003","journal-title":"Magn Reson Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1016\/j.neuroimage.2008.10.055","article-title":"Bayesian analysis of neuroimaging data in FSL","volume":"45","author":"M W Woolrich","year":"2009","journal-title":"Neuroimage"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"116137","DOI":"10.1016\/j.neuroimage.2019.116137","article-title":"MRtrix3: a fast, flexible and open software framework for medical image processing and visualisation","volume":"202","author":"J D Tournier","year":"2019","journal-title":"Neuroimage"},{"issue":"06","key":"ref18","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1109\/TMI.2010.2046908","article-title":"N4ITK: improved N3 bias correction","volume":"29","author":"N J Tustison","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"S M Smith","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.neuroimage.2016.06.058","article-title":"Incorporating outlier detection and replacement into a non-parametric framework for movement and distortion correction of diffusion MR images","volume":"141","author":"J LR Andersson","year":"2016","journal-title":"Neuroimage"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"S M Smith","year":"2004","journal-title":"Neuroimage"},{"issue":"04","key":"ref23","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"S M Smith","year":"2006","journal-title":"Neuroimage"},{"issue":"02","key":"ref24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2013a metadata-driven 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Roland","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"05","key":"ref28","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00234-019-02357-z","article-title":"The splenium of the corpus callosum: embryology, anatomy, function and imaging with pathophysiological hypothesis","volume":"62","author":"J Blaauw","year":"2020","journal-title":"Neuroradiology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neuroimage.2017.02.017","article-title":"Impaired visual short-term memory capacity is distinctively associated with structural connectivity of the posterior thalamic radiation and the splenium of the corpus callosum in preterm-born adults","volume":"150","author":"A Menegaux","year":"2017","journal-title":"Neuroimage"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.nicl.2013.11.007","article-title":"Alterations in the optic radiations of very preterm children-perinatal predictors and relationships with visual outcomes","volume":"4","author":"D K Thompson","year":"2013","journal-title":"Neuroimage Clin"},{"issue":"05","key":"ref31","doi-asserted-by":"crossref","first-page":"e1184","DOI":"10.1542\/peds.2007-1924","article-title":"Quality of general movements is related to white matter pathology in very preterm infants","volume":"121","author":"A J Spittle","year":"2008","journal-title":"Pediatrics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jpeds.2020.12.056","article-title":"Associations between early structural magnetic resonance imaging, Hammersmith Infant Neurological Examination, and General Movements Assessment in infants born very preterm","volume":"232","author":"K Harpster","year":"2021","journal-title":"J Pediatr"},{"issue":"02","key":"ref33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1055\/s-2003-39597","article-title":"General movements detect early signs of hemiplegia in term infants with neonatal 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brain injury","volume":"39","author":"S Mitra","year":"2019","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000454856","article-title":"Diffusion tensor imaging detects occult cerebellar injury in severe neonatal hypoxic-ischemic encephalopathy","volume":"39","author":"M E Lemmon","year":"2017","journal-title":"Dev Neurosci"},{"issue":"02","key":"ref38","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/jon.12572","article-title":"The role of diffusion tensor imaging in detecting hippocampal injury following neonatal hypoxic-ischemic encephalopathy","volume":"29","author":"J Salas","year":"2019","journal-title":"J Neuroimaging"},{"issue":"04","key":"ref39","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/dmcn.12618","article-title":"Fractional anisotropy alterations in individuals born preterm: a diffusion tensor imaging meta-analysis","volume":"57","author":"K 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