{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:26:41Z","timestamp":1790278001504,"version":"4.1.0"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background and study aims\u2002Epiphrenic diverticula are rare and mainly occur in patients with underlying esophageal motility disorders. The current standard treatment is surgical diverticulectomy often combined by myotomy and is associated with significant adverse event (AE) rates. The aim of this study was to examine the efficacy and safety of peroral endoscopic myotomy in reducing esophageal symptoms in patients with esophageal diverticula.<\/jats:p>\n                  <jats:p>Patients and methods\u2002We performed a retrospective cohort study including patients with an esophageal diverticulum who underwent POEM between October 2014 and December 2022.\u200aAfter informed consent, data were extracted from medical records and patients completed a survey by telephone. The primary outcome was treatment success, defined as Eckardt score below 4 with a minimal reduction of 2 points.<\/jats:p>\n                  <jats:p>Results\u2002Seventeen patients (mean age 71 years, 41.2\u200a% female) were included. Achalasia was confirmed in 13 patients (13\u200a\/17, 76.5\u200a%), Jackhammer esophagus in two patients (2\u200a\/17, 11.8\u200a%), diffuse esophageal spasm in one patient (1\u200a\/17, 5.9\u200a%) and in one patient no esophageal motility disorder was found (1\u200a\/17, 5.9\u200a%). Treatment success was 68.8\u200a% and only one patient (6.3\u200a%) underwent retreatment (pneumatic dilatation). Median Eckardt scores decreased from 7 to 1 after POEM (p\u200a&lt;\u200a0.001). Mean size of the diverticula decreased from 3.6\u200acm to 2.9\u200acm after POEM (p\u200a&lt;\u200a0.001). Clinical admission was one night for all patients. AEs occurred in two patients (11.8\u200a%) which were classified as grade II and IIIa (AGREE classification).<\/jats:p>\n                  <jats:p>Conclusions\u2002POEM is effective and safe to treat patients with esophageal diverticula and an underlying esophageal motility disorder.<\/jats:p>","DOI":"10.1055\/a-2071-6744","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T19:29:46Z","timestamp":1681241386000},"page":"E546-E552","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and safety of peroral endoscopic myotomy for esophageal diverticula"],"prefix":"10.1055","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3721-8279","authenticated-orcid":false,"given":"Elise M.","family":"Wessels","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Centres, Gastroenterology & Hepatology, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen M.","family":"Schuitenmaker","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Centres, Gastroenterology & Hepatology, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.J.","family":"Bastiaansen","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Centres, Gastroenterology & Hepatology, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fockens","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Centres, Gastroenterology & Hepatology, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen M.C.","family":"Masclee","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Centres, Gastroenterology & Hepatology, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert J.","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Centres, Gastroenterology & Hepatology, Duivendrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1177\/000313481107701239","article-title":"High resolution manometry findings in patients with esophageal epiphrenic diverticula","volume":"77","author":"F P Vicentine","year":"2011","journal-title":"Am Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/nmo.12739","article-title":"Esophageal diverticula are associated with propagating peristalsis: a study utilizing high-resolution manometry","volume":"28","author":"D A Carlson","year":"2016","journal-title":"Neurogastroenterol Motil"},{"key":"ref3","first-page":"593","article-title":"Physiopathology of lower esophageal diverticulum and 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diverticulum","volume":"31","author":"H Sato","year":"2016","journal-title":"J Gastroenterol Hepatol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"E14","DOI":"10.1055\/s-0034-1390735","article-title":"Salvage peroral endoscopic myotomy for esophageal diverticulum","volume":"47","author":"H Sato","year":"2015","journal-title":"Endoscopy"},{"key":"ref25","first-page":"595","article-title":"A case of diffuse esophageal spasm treated with peroral endoscopic myotomy","volume":"72","author":"Y Sugihara","year":"2018","journal-title":"Acta Med Okayama"},{"key":"ref26","first-page":"81","article-title":"Peroral endoscopic myotomy for an achalasia patient with multiple esophageal diverticula","volume":"109","author":"Y Tan","year":"2017","journal-title":"Rev Esp Enferm Dig"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/gut.2003.029298","article-title":"Pneumatic dilation for achalasia: late results of a prospective follow up 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years","volume":"37","author":"Z Nabi","year":"2022","journal-title":"Dysphagia"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1055\/a-0759-1428","article-title":"An international study on the use of peroral endoscopic myotomy (POEM) in the management of esophageal diverticula: the first multicenter D-POEM experience","volume":"51","author":"J Yang","year":"2019","journal-title":"Endoscopy"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1007\/s00464-020-07593-6","article-title":"Peroral endoscopic myotomy for the treatment of esophageal diverticulum: an experience in China","volume":"35","author":"X Zeng","year":"2021","journal-title":"Surg Endosc"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s00455-021-10252-0","article-title":"Per oral endoscopic myotomy for the management of large esophageal diverticula (D-POEM): Safe and effective modality for complete septotomy","volume":"37","author":"J Samanta","year":"2022","journal-title":"Dysphagia"}],"container-title":["Endoscopy International 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