{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:11:54Z","timestamp":1778127114314,"version":"3.51.4"},"reference-count":46,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Over the last years, Sideritis extracts were shown to improve memory. However, their potential to promote the generation of new neurons, starting with the neuronal differentiation of\n          neural stem cells, remains unexplored. Therefore, the present study aimed to evaluate the neurogenic effects of different Sideritis infusions in neural stem and precursor cells and\n          their impact on cell viability. Moreover, the metabolic fingerprints were recorded using LC-DAD, LC-HRESIMS, and GC-MS. The neurogenic potential of infusions of the eight Sideritis\n          taxa tested was as potent as the classical neuronal inducer combination of retinoic acid and valproic acid. Further cytotoxicity assays revealed that the IC50 values of the\n          extracts were between 163 and 322\u2009\u00b5g\/mL. Hierarchical cluster analyses of the metabolic fingerprints unveiled that the two Sideritis taxa with the lowest IC50 values were\n          the most divergent in the analytical techniques used. As the analysis focused on polyphenols, it is reasonable to assume that these compounds are responsible for the effect on the cell\n          viability of SH-SY5Y neuroblastoma cells. This study is the first report on the neurogenic potential of Sideritis taxa and might support the use of Sideritis herbal\n          preparations in the context of neurodegenerative diseases.<\/jats:p>","DOI":"10.1055\/a-2072-2351","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T23:09:30Z","timestamp":1681340970000},"page":"1087-1096","source":"Crossref","is-referenced-by-count":5,"title":["Metabolic Fingerprinting of Different Sideritis Taxa Infusions and Their Neurogenic Activity"],"prefix":"10.1055","volume":"89","author":[{"given":"Ekaterina-Michaela","family":"Tomou","sequence":"additional","affiliation":[{"name":"Section of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis,\n          Zografou, Athens, Greece"},{"name":"Weihenstephan-Triesdorf University of Applied Sciences, Organic-Analytical Chemistry, Straubing, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Bieler","sequence":"additional","affiliation":[{"name":"Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, Salzburg,\n          Austria"},{"name":"Austrian Cluster for Tissue Regeneration, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Sp\u00f6ttl","sequence":"additional","affiliation":[{"name":"TUM Campus Straubing for Biotechnology and Sustainability, Technical University of Munich, Straubing, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien","family":"Couillard-Despres","sequence":"additional","affiliation":[{"name":"Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, Salzburg,\n          Austria"},{"name":"Austrian Cluster for Tissue Regeneration, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-1407","authenticated-orcid":false,"given":"Helen","family":"Skaltsa","sequence":"additional","affiliation":[{"name":"Section of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis,\n          Zografou, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8895-9416","authenticated-orcid":false,"given":"Corinna","family":"Urmann","sequence":"additional","affiliation":[{"name":"Weihenstephan-Triesdorf University of Applied Sciences, Organic-Analytical Chemistry, Straubing, Germany"},{"name":"TUM Campus Straubing for Biotechnology and Sustainability, Technical University of Munich, Straubing, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jep.2011.03.014","article-title":"Sideritis spp.: uses, chemical composition and pharmacological activities\u2013a review","volume":"135","author":"E Gonz\u00e1lez-Burgos","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s40199-019-00261-8","article-title":"Genus Sideritis, section Empedoclia in southeastern Europe and Turkey \u2013 studies in ethnopharmacology and recent progress of biological activities","volume":"27","author":"I Aneva","year":"2019","journal-title":"DARU J Pharm Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/4513792","article-title":"Ethnobotanical study of medicinal plants used in Central Macedonia, 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