{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:21Z","timestamp":1787004861143,"version":"build-2736575974"},"reference-count":53,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Eintr\u00fcbungen von Acryllinsen durch Materialver\u00e4nderungen stellen schwerwiegende Komplikationen dar, welche die sehr guten postoperativen Visusergebnisse unkomplizierter Kataraktoperationen gef\u00e4hrden. F\u00fcr hydrophobe Acryllinsen besteht die M\u00f6glichkeit einer Bildung von Glistenings, bei hydrophilen Acryllinsen besteht das Risiko einer Kalzifikation durch Kalziumphosphate. Im Laufe der Zeit wurden verschiedene Methoden entwickelt, um die Eintr\u00fcbungen hydrophiler Acryllinsen zu untersuchen. Ziel der vorliegenden Arbeit ist eine Methoden\u00fcbersicht \u00fcber die histologischen Standardf\u00e4rbungen und M\u00f6glichkeiten der Replikation einer IOL-Kalzifikation. Mittels histologischer F\u00e4rbungen l\u00e4sst sich die Kalzifikation von Eintr\u00fcbungen anderer Art differenzieren und die Auspr\u00e4gung der Kalzifikation beurteilen. Durch die Entwicklung von In-vivo- und In-vitro-Modellen zur Replikation konnten der Kalzifikation zugrunde liegende Pathomechanismen identifiziert werden. In-vivo-Modelle eignen sich\n          zur Beurteilung der Biokompatibilit\u00e4t verwendeter Linsenmaterialien. Mithilfe eines In-vitro-Modells in Bioreaktoren kann die Kinetik der Kristallbildung untersucht werden. Die Verwendung einer Elektrophorese zur Replikation der Kalzifikation unter standardisierten Bedingungen erlaubt einen Vergleich verschiedener Linsenmaterialien bez\u00fcglich des Kalzifikationsrisikos. Die Kombination verschiedener Analyse- und Replikationsmethoden kann in Zukunft dazu verwendet werden, die Pathomechanismen der Kalziumphosphatbildung und den Zusammenhang zu Risikofaktoren n\u00e4her zu untersuchen. Dies k\u00f6nnte dazu beitragen, die Kalzifikation hydrophiler Acryllinsen und damit einhergehende Explantationen und Komplikationen zu vermeiden.<\/jats:p>","DOI":"10.1055\/a-2073-8526","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T19:19:56Z","timestamp":1688152796000},"page":"960-970","source":"Crossref","is-referenced-by-count":2,"title":["Opacification of Hydrophilic Acrylic Intraocular Lenses: Overview of Laboratory Methods for Histological Analysis and Replication of IOL Calcification"],"prefix":"10.1055","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0146-0418","authenticated-orcid":false,"given":"Leoni","family":"Britz","sequence":"additional","affiliation":[{"name":"Universit\u00e4ts-Augenklinik, Universit\u00e4tsKlinikum Heidelberg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja 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