{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:22Z","timestamp":1787004862633,"version":"build-2736575974"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective We aimed to investigate the relationship between the hyperemesis\n                    gravidarum (HG) and maternal serum phoenixin-14 (PNX-14) concentrations.<\/jats:p>\n                  <jats:p>Materials and methods This cross-sectional study was conducted with 88\n                    pregnant women who applied to the Umraniye Training and Research Hospital\n                    Gynecology and Obstetrics Clinic between February 2022 and October 2022. The HG\n                    group consisted of 44 pregnant women diagnosed with HG between the 7th and 14th\n                    gestational weeks, and the control group consisted of 44 healthy pregnant women\n                    matched with the HG group in terms of age, BMI, and gestational week.\n                    Demographic characteristics, ultrasound findings, and laboratory outcomes were\n                    noted. The two groups were compared in terms of maternal serum PNX-14\n                    concentrations.<\/jats:p>\n                  <jats:p>Results Gestational age at blood sampling for PNX-14 was similar in both\n                    groups (p=1.000). While maternal serum PNX-14 concentration was\n                    85.5\u2009pg\/ml in the HG group, it was 71.3\u2009pg\/ml in\n                    the control group (p=0.012). ROC analysis was performed to determine the\n                    value of maternal serum PNX-14 concentration in terms of predicting HG. AUC\n                    analysis of maternal serum PNX-14 for HG estimation was 0.656 (p=0.012,\n                    95% CI=0.54\u20130.77). The optimal cutoff value for maternal\n                    serum PNX-14 concentration was determined as 79.81\u2009pg\/ml with\n                    59% sensitivity and 59% specificity.<\/jats:p>\n                  <jats:p>Conclusion In this study, maternal serum PNX-14 concentration was found to\n                    be higher in pregnant women with HG, which indicates that high serum PNX-14\n                    concentrations may have an anorexigenic effect on food intake in pregnancy.\n                    Concentrations of other PNX isoforms in HG and changes in PNX concentrations in\n                    pregnant women with HG who regained weight after treatment remain to be\n                    investigated.<\/jats:p>","DOI":"10.1055\/a-2073-8652","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T19:00:23Z","timestamp":1684782023000},"page":"347-353","source":"Crossref","is-referenced-by-count":2,"title":["Investigation of Serum Phoenixin-14 Concentration in Pregnant Women\n                    Diagnosed with Hyperemesis Gravidarum"],"prefix":"10.1055","volume":"227","author":[{"given":"S\u00fcmeyye","family":"\u00c7imenli","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Umraniye Training and Research Hospital,\n                    Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-7199","authenticated-orcid":false,"given":"\u0130brahim","family":"Kale","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Umraniye Training and Research Hospital,\n                    Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Muhcu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Maternal Fetal Unit, Umraniye Training and\n                    Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"ref1","volume-title":"Hyperemesis Gravidarum. In: StatPearls","author":"L K Jennings","year":"2022"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejogrb.2021.09.004","article-title":"The windsor definition for hyperemesis gravidarum: A multistakeholder\n                    international consensus definition","volume":"266","author":"LA W Jansen","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/1742-6723.13909","article-title":"Review article: Management of hyperemesis gravidarum and nausea and vomiting in\n                    pregnancy","volume":"34","author":"S A Lowe","year":"2022","journal-title":"Emerg Med Australas"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1471-2393-9-26","article-title":"Epidemiology of nausea and vomiting of pregnancy: prevalence, severity,\n                    determinants, and the importance of race\/ethnicity","volume":"9","author":"A Lacasse","year":"2009","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/s41467-018-03258-0","article-title":"Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis\n                    gravidarum","volume":"9","author":"M S Fejzo","year":"2018","journal-title":"Nat Commun"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"c2050","DOI":"10.1136\/bmj.c2050","article-title":"Recurrence of hyperemesis gravidarum across generations: population based cohort\n                    study","volume":"340","author":"A Vikanes","year":"2010","journal-title":"BMJ"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1365-2826.2012.02381.x","article-title":"A novel reproductive peptide, phoenixin","volume":"25","author":"GL C Yosten","year":"2013","journal-title":"J Neuroendocrinol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"8378","DOI":"10.3390\/ijms21218378","article-title":"Phoenixin: More than reproductive peptide","volume":"21","author":"M Billert","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"956500","DOI":"10.3389\/fmolb.2022.956500","article-title":"Regulation and physiological functions of phoenixin","volume":"9","author":"H Liang","year":"2022","journal-title":"Front Mol Biosci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.neuroscience.2013.07.057","article-title":"Phoenixin: A novel peptide in rodent sensory ganglia","volume":"250","author":"R-M Lyu","year":"2013","journal-title":"Neuroscience"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.neuroscience.2015.09.055","article-title":"Phoenixin: A candidate pruritogen in the mouse","volume":"310","author":"A Cowan","year":"2015","journal-title":"Neuroscience"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1210\/me.2016-1039","article-title":"Phoenixin activates immortalized GnRH and kisspeptin neurons through the novel\n                    receptor GPR173","volume":"30","author":"A K Treen","year":"2016","journal-title":"Mol Endocrinol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.peptides.2017.08.004","article-title":"Phoenixin-14 injected intracerebroventricularly but not intraperitoneally\n                    stimulates food intake in rats","volume":"96","author":"M Schalla","year":"2017","journal-title":"Peptides"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1080\/1028415X.2019.1692494","article-title":"Longitudinal study on novel neuropeptides phoenixin, spexin and kisspeptin in\n                    adolescent inpatients with anorexia nervosa \u2013 association with\n                    psychiatric symptoms","volume":"24","author":"A Pa\u0142asz","year":"2021","journal-title":"Nutr Neurosci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/j.bbalip.2018.09.006","article-title":"Phoenixin-14 stimulates differentiation of 3T3-L1 preadipocytes via\n                    cAMP\/Epac-dependent mechanism","volume":"1863","author":"M Billert","year":"2018","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.3390\/ijms19061726","article-title":"Phoenixin-a pleiotropic gut-brain peptide","volume":"19","author":"M A Schalla","year":"2018","journal-title":"Int J Mol Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.brainres.2019.03.034","article-title":"Intracerebroventricular injection of phoenixin alters feeding behavior and\n                    activates nesfatin-1 immunoreactive neurons in rats","volume":"1715","author":"T Friedrich","year":"2019","journal-title":"Brain Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s00018-017-2661-3","article-title":"Phoenixin-14: detection and novel physiological implications in cardiac\n                    modulation and cardioprotection","volume":"75","author":"C Rocca","year":"2018","journal-title":"Cell Mol Life Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.cbpb.2018.07.007","article-title":"Phoenixin participated in regulation of food intake and growth in spotted scat,\n                    Scatophagus argus","volume":"226","author":"M Wang","year":"2018","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"R917","DOI":"10.1152\/ajpregu.00019.2020","article-title":"Phoenixin-20 suppresses food intake, modulates glucoregulatory enzymes, and\n                    enhances glycolysis in zebrafish","volume":"318","author":"J J Rajeswari","year":"2020","journal-title":"Am J Physiol Regul Integr Comp Physiol"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2073-8652.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T18:45:41Z","timestamp":1697222741000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2073-8652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,22]]},"references-count":20,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2023,10,13]]},"published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2073-8652","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,22]]}}}