{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:50Z","timestamp":1740126830815,"version":"3.37.3"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Aseptic liver abscesses occur very rarely. Clinical guidelines on the management of the disease do not exist, and the diagnosis is challenging.<\/jats:p><jats:p>We screen MEDLINE and PUBMED databases for relevant case reports from inception to November 2022. Information on patient age, sex, initial symptoms, the extent of abscess formation, further diagnoses, treatment, and course of the disease is analyzed.<\/jats:p><jats:p>Thirty cases with sterile hepatic abscess formation are identified. In most patients (n=18), the spleen is affected as well. Patients typically present with fever, abdominal pain, and increased inflammatory values. Comorbidity with inflammatory bowel disease is very common (n=18) and is associated with a significantly younger age at the time of hepatic abscess development. In addition, many patients show autoimmune-mediated cutaneous, ocular, or arthritic rheumatoid manifestations. Histological examination of abscess material reveals neutrophilic infiltration. The majority of patients initially receive corticosteroid therapy. Furthermore, response to azathioprine, anti-TNF-\u03b1 antibodies, and other immunomodulatory drugs is reported. Ten out of fourteen patients with a long-term follow-up (\u2265 36 months) have at least one relapse of hepatic abscess formation.<\/jats:p><jats:p>Aseptic hepatic abscesses should be considered in the case of sterile punctures and non-response to antibiotics. Patients with aseptic liver abscesses have a high risk of recurrence warranting immunomodulatory maintenance therapy.<\/jats:p>","DOI":"10.1055\/a-2075-5082","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T23:27:35Z","timestamp":1697153255000},"page":"208-217","source":"Crossref","is-referenced-by-count":0,"title":["Symptoms and Management of Aseptic Liver Abscesses"],"prefix":"10.1055","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-8382","authenticated-orcid":false,"given":"Susanne","family":"Hafner","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, University Ulm Medical Centre, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Seufferlein","sequence":"additional","affiliation":[{"name":"Internal Medicine I, University Ulm Medical Centre, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kleger","sequence":"additional","affiliation":[{"name":"Internal Medicine I, University Ulm Medical Centre, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Internal Medicine I, University Ulm Medical Centre, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e0628","DOI":"10.1097\/MD.0000000000010628","article-title":"Characteristics and management of pyogenic liver abscess: A European experience","volume":"97","author":"C Serraino","year":"2018","journal-title":"Medicine"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"158","DOI":"10.14218\/JCTH.2016.00004","article-title":"The Evolving Nature of Hepatic Abscess: A 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