{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:49Z","timestamp":1740126829030,"version":"3.37.3"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present here a case of a 39-year-old patient who presented with celiac-disease-like\n      symptoms and MARSH 3a histology in duodenal biopsies under normal diet. Interestingly, HLA\n      genotyping and celiac-specific serology were negative, primarily leading to exclusion of\n      celiac disease. However, biopsies from a second endoscopy a couple of months later (still\n      under normal diet) showed histologic progression of the disease to MARSH 3b and led to the\n      re-evaluation of the out-of-hospital-obtained histological samples by a pathologist\n      experienced in celiac disease. The second biopsy described previously as MARSH 3b turned out\n      to be non-specific and was therefore re-classified as MARSH 0. After all known causes of\n      duodenal villous atrophy were excluded by a thorough evaluation, a correlation between the\n      first biopsy (MARSH 3a) and Truvada intake could be established. After Truvada discontinuation\n      and under normal diet, normalisation of duodenal mucosa was observed, leading to the\n      assumption that Truvada could lead to celiac-like enteropathy.<\/jats:p>","DOI":"10.1055\/a-2079-6445","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T22:50:27Z","timestamp":1684191027000},"page":"404-406","source":"Crossref","is-referenced-by-count":1,"title":["Preexposition Prophylaxis With Truvada (Tenofovir\/Emtricitabine) as Potential Cause of Celiac Disease-Like Enteropathy"],"prefix":"10.1055","volume":"62","author":[{"given":"Merima","family":"Herac-Kornauth","sequence":"first","affiliation":[{"name":"Clinical Institute of Pathology, Medical University of Vienna, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Kazemi-Shirazi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Medical University of Vienna, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7331-587X","authenticated-orcid":false,"given":"Jagoda","family":"Pokryszka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Medical University of Vienna, Wien, Austria"},{"name":"Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Wichlas","sequence":"additional","affiliation":[{"name":"Gruppenpraxis Interne Donaustadt, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Vogelsang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Medical University of Vienna, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Medical University of Vienna, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"e629","DOI":"10.1016\/S2352-3018(18)30215-7","article-title":"Population-level effectiveness of rapid, targeted, high-coverage roll-out of HIV\n          pre-exposure prophylaxis in men who have sex with men: the EPIC-NSW prospective cohort\n          study","volume":"5","author":"AE Grulich","year":"2018","journal-title":"Lancet HIV"},{"issue":"1034","key":"ref2","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1016\/S0140-6736(22)00794-2","article-title":"Coeliac disease","volume":"399","author":"C Catassi","year":"2022","journal-title":"Lancet (London, England)"},{"issue":"03","key":"ref3","first-page":"394","article-title":"Screening for celiac disease: a prospective study on the value of 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readouts in celiac\n          disease","volume":"8","author":"J Taavela","year":"2013","journal-title":"PloS one"},{"issue":"22","key":"ref7","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1001\/jama.2019.2591","article-title":"Preexposure Prophylaxis for the Prevention of HIV Infection: Evidence Report and\n          Systematic Review for the US Preventive Services Task Force","volume":"321","author":"R Chou","year":"2019","journal-title":"Jama"},{"issue":"04","key":"ref8","first-page":"140","article-title":"Nucleoside analogue reverse transcriptase inhibitor options: a re-examination of\n          the class","volume":"14","author":"SM Hammer","year":"2006","journal-title":"Top HIV Med"},{"issue":"05","key":"ref9","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/labinvest.2009.14","article-title":"Tenofovir renal toxicity targets mitochondria of renal proximal tubules","volume":"89","author":"JJ Kohler","year":"2009","journal-title":"Lab Invest"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3389\/fgene.2020.00497","article-title":"Mitochondrial Toxicogenomics for Antiretroviral Management: HIV Post-exposure\n          Prophylaxis in Uninfected Patients","volume":"11","author":"M Ba\u00f1\u00f3","year":"2020","journal-title":"Front Genet"},{"issue":"10","key":"ref11","doi-asserted-by":"publisher","first-page":"e3498","DOI":"10.7759\/cureus.3498","article-title":"Eosinophilic Colitis Associated with Emtricitabine\/Tenofovir","volume":"10","author":"MR Lozier","year":"2018","journal-title":"Cureus"},{"issue":"01","key":"ref12","first-page":"47","article-title":"Olmesartan and drug-induced enteropathy","volume":"39","author":"TH Tran","year":"2014","journal-title":"P t"}],"container-title":["Zeitschrift f\u00fcr Gastroenterologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2079-6445.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T14:18:33Z","timestamp":1730816313000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2079-6445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,15]]},"references-count":12,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2024,3,5]]},"published-print":{"date-parts":[[2024,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2079-6445","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0044-2771","1439-7803"],"issn-type":[{"type":"print","value":"0044-2771"},{"type":"electronic","value":"1439-7803"}],"subject":[],"published":{"date-parts":[[2023,5,15]]}}}