{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T20:10:08Z","timestamp":1781295008469,"version":"3.54.1"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>\n            Purpose\u2002To assess radiation exposure and diagnostic performance of bilateral inferior petrosal sinus sampling for the distinction of pituitary and ectopic adrenocorticotropin-dependent Cushing\u02bcs syndrome.<\/jats:p><jats:p>\n            Materials and Methods\u2002Procedural data of bilateral inferior petrosal sinus procedures were retrospectively evaluated. The analysis included the patients\u2019 clinical and demographic data, procedural radiation exposure, and complication rates, sampling results, clinical course of the patients, and calculation of diagnostic performance data.<\/jats:p><jats:p>\n            Results\u2002The cases of 46 patients diagnosed with adrenocorticotropin-dependent Cushing\u02bcs syndrome were evaluated. Bilateral inferior petrosal sinus sampling was successfully performed in 97.8\u200a% of the cases. The overall median procedure-related fluoroscopy time was 7.8\u200amin. (range 3.2\u201336.2\u200amin.), and the median procedural dose area product was 11.9 Gy*cm2 (range 2.1\u201373.7 Gy*cm2). Radiation doses due to digital subtraction angiography series for visualization of the inferior petrosal sinus were 3.6 Gy*cm2 (range 1.0\u201318.1 Gy*cm2). Radiation doses due to fluoroscopy had a higher impact on the overall radiation exposure and were significantly influenced by the patients\u2019 habitus. The sensitivity, specificity, and positive and negative predictive values were 84\u200a%, 100\u200a%, 100\u200a%, and 72\u200a% before stimulation with corticotropin-releasing hormone, and 97\u200a%, 100\u200a%, 100\u200a%, and 93\u200a% after stimulation. Concordance between magnetic resonance imaging studies and bilateral inferior petrosal sinus sampling results was only found in 35.6\u200a% of the cases. The periprocedural complication rate was 2.2\u200a%, with one patient experiencing vasovagal syncope during catheterization.<\/jats:p><jats:p>\n            Conclusion\u2002Bilateral inferior petrosal sinus sampling is a safe procedure with high technical success rates und excellent diagnostic performance. The procedure-related radiation exposure shows large variations and depends on the complexity of cannulation as well as the patients\u2019 habitus. Fluoroscopy accounted for the largest proportion of radiation exposure. Acquisition of digital subtraction angiography series for the verification of correct catheter placement appears justified.<\/jats:p><jats:p>\n            Key Points:\u2002<\/jats:p><jats:p>\n            Citation Format\n          <\/jats:p>","DOI":"10.1055\/a-2083-9942","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T23:00:52Z","timestamp":1684969252000},"page":"1009-1017","source":"Crossref","is-referenced-by-count":3,"title":["Bilateral inferior petrosal sinus sampling: Procedural data from a German single-center study"],"prefix":"10.1055","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3541-5287","authenticated-orcid":false,"given":"Anne Marie","family":"Augustin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Detomas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Hartung","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Thurner","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Tr\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Deutschbein","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital W\u00fcrzburg, Germany"},{"name":"Medicover Oldenburg MVZ, Medicover Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Kickuth","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/S0140-6736(14)61375-1","article-title":"Cushing\u02bcs syndrome","volume":"386","author":"A 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thrombo-embolism following inferior petrosal sinus sampling in Cushing\u02bcs disease","volume":"23","author":"K Obuobie","year":"2000","journal-title":"J Endocrinol Invest"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1136\/neurintsurg-2015-012164","article-title":"Bilateral inferior petrosal sinus sampling: experience in 327 patients","volume":"9","author":"A Deipolyi","year":"2017","journal-title":"J Neurointerv Surg"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/978-1-60327-449-4_9","volume-title":"Inferior Petrosal Sampling for the Differential Diagnosis of ACTH-Dependent Cushing\u02bcs Syndrome","author":"B R Javorsky","year":"2011"}],"container-title":["R\u00f6Fo - Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden 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