{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:56:49Z","timestamp":1697086609608},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Exsudative Epidermitis (EE) \u2013 meist, aber nicht ausschlie\u00dflich\n                    ausgel\u00f6st durch Staphylococcus (St.) hyicus \u2013 ist ein\n                    verbreitetes Problem auf Ferkelerzeugerbetrieben. So auch in einem westdeutschen\n                    eigenremontierenden Betrieb mit 350 produktiven Sauen. Beginnend mit\n                    schw\u00e4rzlich-schuppigen Hautl\u00e4sionen bei einzelnen Saug- und\n                    Aufzuchtferkeln sowie Jung- und Altsauen, bestand bereits in der\n                    n\u00e4chsten Absetzgruppe bei etwa 50% der Ferkel die klinische\n                    Verdachtsdiagnose der EE. Die Mortalit\u00e4tsrate im Aufzuchtstall stieg bei\n                    betroffenen Ferkelgruppen auf 10%. Sowohl die (histo)pathologische\n                    Untersuchung als auch der wiederholte Nachweis von St. hyicus aus\n                    Hauttupfern sowie Tupfern aus anderen Organen best\u00e4tigten die klinische\n                    Verdachtsdiagnose. Neben St. hyicus konnte aus einzelnen Hauttupfern\n                    zudem St. chromogenes isoliert werden. In der weiterf\u00fchrenden\n                    Charakterisierung der St. hyicus-St\u00e4mme wurden ExhA und SHETA als\n                    beteiligte Toxine identifiziert, und die Isolate zeigten unter anderem\n                    Resistenzen gegen Penicilline und Aminopenicilline. Kurzfristig verbesserte eine\n                    bestandsweise antibiotische Therapie mit einem Trimethoprim-Sulfadiazin-haltigen\n                    Pr\u00e4parat in Kombination mit der individuellen Behandlung einzelner Tiere\n                    und dem Waschen mit einer jodhaltigen L\u00f6sung die klinische Symptomatik.\n                    Zur dauerhaften Reduktion des Einsatzes antibiotischer Mittel wurde sich\n                    f\u00fcr die Herstellung eines bestandsspezifischen Impfstoffs mit den\n                    isolierten St. hyicus- und St. chromogenes-St\u00e4mmen\n                    entschieden, welcher als Mutterschutzvakzine an die Sauen appliziert wurde.\n                    Zus\u00e4tzlich wurde die externe und interne Biosicherheit anhand eines\n                    objektiven Fragebogens (Bio-check.UGentTM) evaluiert und angepasst.\n                    Die Kombination der Ma\u00dfnahmen f\u00fchrte zu einer langfristigen\n                    Besserung des klinischen Geschehens. Das erneute Auftreten leichter\n                    Hautl\u00e4sionen bei einzelnen Ferkeln konnte mit der Anpassung des\n                    bestandsspezifischen Impfstoffes durch neu gewonnene St. hyicus-Isolate\n                    zielf\u00fchrend in den Griff bekommen werden. Der Fallbericht verdeutlicht,\n                    wie mit der Kombination aus kontinuierlichem Monitoring, Einzeltier- und\n                    Gruppentherapie, Evaluierung der Biosicherheit und dem Einsatz einer\n                    angemessenen Immunprophylaxe selbst hartn\u00e4ckige F\u00e4lle der EE auf\n                    ein Minimum reduziert werden k\u00f6nnen.<\/jats:p>","DOI":"10.1055\/a-2088-6163","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T23:06:11Z","timestamp":1691535971000},"page":"248-256","source":"Crossref","is-referenced-by-count":0,"title":["Umgang mit erh\u00f6hten Ferkelverlusten nach Auftreten von\n                exsudativer Epidermitis \u2013 ein Fallbericht"],"prefix":"10.1055","volume":"51","author":[{"given":"Lutz","family":"Brimmers","sequence":"additional","affiliation":[{"name":"Tierarztpraxis Am Kapellhof, Geldern"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhle","family":"Buch","sequence":"additional","affiliation":[{"name":"AniCon Labor GmbH, H\u00f6ltinghausen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Harlizius","sequence":"additional","affiliation":[{"name":"Schweinegesundheitsdienst der Landwirtschaftskammer\n                    Nordrhein-Westfalen, Haus D\u00fcsse, Bad Sassendorf"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Kuczka","sequence":"additional","affiliation":[{"name":"Chemisches und Veterin\u00e4runtersuchungsamt Rhein-Ruhr-Wupper\n                    (CVUA-RRW), Krefeld"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kleinmans","sequence":"additional","affiliation":[{"name":"Tierarztpraxis Am Kapellhof, Geldern"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ladinig","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Schweine, Department f\u00fcr\n                    Nutztiere und \u00f6ffentliches Gesundheitswesen in der\n                    Veterin\u00e4rmedizin, Veterin\u00e4rmedizinische Universit\u00e4t\n                    Wien, \u00d6sterreich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Kreutzmann","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Schweine, Department f\u00fcr\n                    Nutztiere und \u00f6ffentliches Gesundheitswesen in der\n                    Veterin\u00e4rmedizin, Veterin\u00e4rmedizinische Universit\u00e4t\n                    Wien, \u00d6sterreich"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"ref1","first-page":"72","volume-title":"Staphylococcus hyicus-Infektion (Exsudative epidermitis, Greasy pig\n                    disease). 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