{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:22:38Z","timestamp":1790947358841,"version":"4.1.0"},"reference-count":55,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2024,11]]},"abstract":"Zusammenfassung<\/jats:title>Antidepressiva, insbesondere die selektiven Serotoninwiederaufnahmehemmer (SSRI),\n sind die meistverordnete psychopharmakologische Arzneistoffgruppe, weshalb eine\n genaue Kenntnis der zu erwartenden unerw\u00fcnschten Arzneimittelwirkungen\n unabdingbar ist. Das erh\u00f6hte Risiko f\u00fcr Blutungsereignisse ist\n vor allem bei Patienten, die mit SSRI behandelt werden, gut belegt. Mit wenigen\n Ausnahmen k\u00f6nnen jedoch auch die anderen antidepressiven\n Arzneistoffgruppen Einfluss auf die Blutgerinnung nehmen und somit das\n Blutungsrisiko erh\u00f6hen. In der nachfolgenden \u00dcbersichtsarbeit\n wird das thrombozyt\u00e4re Serotoninsystem vorgestellt und die\n Angriffspunkte der unterschiedlichen Antidepressiva erl\u00e4utert.\n Anschlie\u00dfend wird die zur Verf\u00fcgung stehende Literatur zu\n Blutungen unter den jeweiligen Antidepressivaklassen bzw. einzelnen Substanzen\n vorgestellt, wobei hier nach M\u00f6glichkeit jeweils Daten aus Meta-Analysen\n herangezogen werden. Neben dem allgemeinen Blutungsrisiko werden zudem einzelne\n Blutungsentit\u00e4ten betrachtet, wie gastrointestinale und Hirnblutungen.\n Zuletzt werden die Auswirkungen von anderen blutgerinnungsf\u00f6rdernden\n Arzneistoffen (Nichtsteroidale Antirheumatika, Thrombozytenaggregationshemmer\n und Antikoagulanzien) in Kombination mit Antidepressiva diskutiert. Mit dem\n vorgestellten Wissen soll es Behandlern in Zukunft leichter fallen\n Entscheidungen hinsichtlich einer geeigneten antidepressiven Pharmakotherapie\n anhand der patientenindividuellen Risikokonstellation zu treffen.<\/jats:p>","DOI":"10.1055\/a-2089-3490","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T22:56:54Z","timestamp":1686956214000},"page":"458-467","source":"Crossref","is-referenced-by-count":8,"title":["Das Blutungsrisiko unter Antidepressiva verstehen und einsch\u00e4tzen"],"prefix":"10.1055","volume":"92","author":[{"given":"Johanna","family":"Seifert","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Sozialpsychiatrie und Psychotherapie,\n Medizinische Hochschule Hannover, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Eckermann","sequence":"additional","affiliation":[{"name":"Arbeitsgemeinschaft f\u00fcr Neuropsychopharmakologie und\n Pharmakopsychiatrie, Arbeitsgruppe Polypharmazie, M\u00fcnchen,\n Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Heck","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Pharmakologie, Medizinische Hochschule\n Hannover, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bleich","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Sozialpsychiatrie und Psychotherapie,\n Medizinische Hochschule Hannover, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Dabbert","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Forensische Psychiatrie und Psychotherapie, Klinikum\n Bremen-Ost gGmbH, Bremen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Grohmann","sequence":"additional","affiliation":[{"name":"Psychiatrie und Psychotherapie, Klinik und Poliklinik der\n Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\n Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sermin","family":"Toto","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Sozialpsychiatrie und Psychotherapie,\n Medizinische Hochschule Hannover, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/978-3-662-66303-5_22","volume-title":"Depression, Angstst\u00f6rungen, bipolare St\u00f6rung, Schizophrenie,\n Aufmerksamkeitsdefizithyperaktivit\u00e4tssyndrom. 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