{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:22Z","timestamp":1787004862588,"version":"build-2736575974"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Hintergrund Ziel dieser Arbeit war es, die Wirkung von 100% autologen Serumaugentropfen bei therapieresistenten Erosiones und Ulcera corneae auf der eigenen Hornhaut vs.\n          transplantierter Hornhaut zu vergleichen.<\/jats:p>\n                  <jats:p>Patienten und Methoden In einer retrospektiven Studie \u00fcber 7 Jahre wurden 263 Behandlungen mit autologen Serumaugentropfen bei therapieresistenten Epitheldefekten untersucht, die\n          zwischen 2007 und 2014 auftraten. Unterschieden wurde, ob der Epitheldefekt (Erosio [88%] vs. Ulcus corneae [12%]) sich auf dem Hornhauttransplantat (48,1%) oder auf der eigenen Hornhaut\n          (51,9%) befand. Zielgr\u00f6\u00dfe war der komplette Epithelschluss innerhalb von 28 Tagen Therapie. Die Rezidivrate im Verlauf wurde ebenfalls untersucht.<\/jats:p>\n                  <jats:p>Ergebnisse Bei 88,2% der behandelten Defekte kam es innerhalb von 28 Behandlungstagen zu einem kompletten Epithelschluss. Bei 5,1% der erfolgreich geschlossenen Defekte kam es nach\n          Abschluss der 1-monatigen Therapie zu einem Rezidiv. Es zeigte sich kein signifikanter Unterschied zwischen der Erfolgsrate von transplantiertem Hornhautgewebe (88,6%) oder eigenem\n          Hornhautgewebe (87,8%; p\u2009=\u20090,137). Die Rezidivrate lag bei transplantierter Hornhaut bei 6,4%, bei der eigenen Hornhaut bei 1,7%. Bei Ulcera (74,2%) zeigte sich eine signifikant reduzierte\n          Erfolgsrate im Vergleich zu den Erosiones (90,3%; p\u2009&lt;\u20090,001). 4,4% der Erosiones und 4,3% der Ulcera rezidivierten im Verlauf.<\/jats:p>\n                  <jats:p>Schlussfolgerungen Die autologen Serumaugentropfen stellen eine gute, nicht invasive und sichere Therapiealternative bei therapieresistenten Epitheldefekten dar, ohne signifikanten\n          Unterschied der Wirkung bei Epitheldefekten auf der eigenen Hornhaut und transplantierter Hornhaut. Die Erfolgsrate, aber nicht die Rezidivrate ist bei Hornhautulcera signifikant geringer\n          als bei Erosiones corneae.<\/jats:p>","DOI":"10.1055\/a-2091-0111","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T19:32:58Z","timestamp":1683747178000},"page":"102-109","source":"Crossref","is-referenced-by-count":2,"title":["Die Wirkung von autologen Serumaugentropfen bei therapieresistenten Erosiones und Ulcera der Kornea bei eigenem im Vergleich zu transplantiertem Gewebe"],"prefix":"10.1055","volume":"241","author":[{"given":"Marie","family":"Leonhard","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum des Saarlandes (UKS), Homburg\/Saar, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Turner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum des Saarlandes (UKS), Homburg\/Saar, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Langenbucher","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Experimentelle Ophthalmologie, Universit\u00e4tsklinikum des Saarlandes, Homburg\/Saar, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0423-3624","authenticated-orcid":false,"given":"Elias","family":"Flockerzi","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum des Saarlandes (UKS), Homburg\/Saar, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9701-8204","authenticated-orcid":false,"given":"Berthold","family":"Seitz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum des Saarlandes (UKS), Homburg\/Saar, 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