{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:32:15Z","timestamp":1762432335920},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die akute Schwangerschaftsfettleber (acute fatty liver in pregnancy, AFLP) ist\n                    mit einer Pr\u00e4valenz von 0,01\u20130,03% eine seltene,\n                    potentiell lebensbedrohliche Komplikation in der Schwangerschaft. Durch die\n                    meist unspezifischen Symptome l\u00e4sst sie sich schwer von anderen, teils\n                    h\u00e4ufigeren, Schwangerschaftserkrankungen wie HELLP Syndrom, aHUS und TTP\n                    abgrenzen. Ihre Seltenheit f\u00fchrt dazu, dass sie durch in der\n                    Geburtshilfe t\u00e4tige Personen als Differentialdiagnose oft nicht in\n                    Erw\u00e4gung gezogen wird. Dabei ist gerade die fr\u00fchzeitige\n                    Diagnosestellung und schnellstm\u00f6gliche Entbindung als einzige kausale\n                    Therapie entscheidend zur Verhinderung schwerwiegender Komplikationen und\n                    m\u00fctterlicher Todesf\u00e4lle. In nachfolgender Arbeit wird anhand von\n                    Fallbeschreibungen dreier Uniklinika die Pathophysiologie, Bedeutung, Diagnose\n                    und Therapie der akuten Schwangerschaftsfettleber f\u00fcr die klinische\n                    Routine hervorgehoben und auf m\u00f6gliche Befunde, welche in der\n                    Diagnosefindung zielf\u00fchrend sind, hingewiesen. Hierbei spielt auch der\n                    angiogene Pr\u00e4eklampsie-Marker sFlt-1 eine Rolle und bietet neue\n                    Betrachtungsweisen pathophsiologischer Ans\u00e4tze.<\/jats:p>","DOI":"10.1055\/a-2096-6230","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T22:45:23Z","timestamp":1690325123000},"page":"466-473","source":"Crossref","is-referenced-by-count":2,"title":["Akute Schwangerschaftsfettleber \u2013 Fallserie einer seltenen\n                    Schwangerschaftskomplikation"],"prefix":"10.1055","volume":"227","author":[{"given":"Martina","family":"Br\u00fcgge","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe,\n                    Universit\u00e4tsklinikum Schleswig-Holstein Campus Kiel, Kiel,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Pecks","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe,\n                    Universit\u00e4tsklinikum Schleswig-Holstein Campus Kiel, Kiel,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Iannaccone","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe,\n                    Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Palz-Fleige","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe,\n                    St.-Johannes-Hospital Dortmund, Dortmund, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Stepan","sequence":"additional","affiliation":[{"name":"Geburtsmedizin, Universit\u00e4tsfrauenklinik Leipzig, Leipzig,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Tauscher","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe,\n                    Universit\u00e4tsklinikum Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.cgh.2015.08.022","article-title":"The Epidemiology of Liver Diseases Unique to Pregnancy in a US Community: A\n                    Population-Based Study","volume":"14","author":"A M Allen","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1097\/ALN.0000000000002597","article-title":"Acute Fatty Liver of Pregnancy: Pathophysiology, Anesthetic Implications, and\n                    Obstetrical 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