{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:45Z","timestamp":1740126885330,"version":"3.37.3"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective We aimed to investigate the relationship between gestational\n                    diabetes mellitus (GDM) and maternal serum hepassocin concentrations.<\/jats:p><jats:p>\n          Materials and methods This cross-sectional study was conducted with 88\n                    pregnant women who applied to the \u00dcmraniye Training and Research\n                    Hospital Gynecology and Obstetrics Clinic between April 2022 and November 2022.\n                    The GDM group consisted of 44 pregnant women who had a 75-g OGTT between the\n                    24th and 28th week of pregnancy and were diagnosed with GDM. The control group\n                    consisted of 44 healthy pregnant women who were matched with the GDM group in\n                    terms of age and body mass index (BMI) and had a normal 75-g OGTT result.\n                    Demographic characteristics, laboratory findings, and perinatal outcomes were\n                    noted. Two groups were compared in terms of maternal serum hepassocin\n                    concentrations.<\/jats:p><jats:p>\n          Results Both groups were similar in terms of age, BMI, weight gain,\n                    gravida, parity, polycystic ovary syndrome history, history of diabetes mellitus\n                    in the family, and the gestational week at blood sampling for hepassocin\n                    (p&gt;0.05 for each). The median maternal serum hepassocin concentration\n                    was found to be 18.21\u2009ng\/ml in the GDM group, while it was\n                    determined as 13.05\u2009ng\/ml in the non-GDM group\n                    (p=0.012). The GDM group was divided into two groups: the group that\n                    only dieted until birth and the group that used insulin until birth for blood\n                    glucose regulation. The median hepassocin concentration was found to be\n                    17.99\u2009ng\/ml in the diet-only GDM group and\n                    32.15\u2009ng\/ml in the insulin-using GDM group. ROC analysis was\n                    performed to determine the value of maternal serum hepassocin concentration in\n                    predicting GDM. AUC analysis of maternal serum hepassocin for estimation of GDM\n                    was 0.656 (p=0.012, 95% CI=0.53\u20130.77). The\n                    optimal threshold value for maternal serum hepassocin concentration was\n                    determined as 14.13\u2009ng\/ml with 61.4% sensitivity and\n                    61.4% specificity.<\/jats:p><jats:p>\n          Conclusion Serum hepassocin concentration evaluated between 24 and 28\n                    weeks of gestation was found to be higher in pregnant women with GDM than in the\n                    non-GDM group. The highest serum hepassocin concentration was found in the GDM\n                    group using insulin for blood glucose regulation. Hepassocin seems to be a\n                    promising molecule that can be used in GDM screening in pregnant women who do\n                    not want to have an OGTT in the future.<\/jats:p>","DOI":"10.1055\/a-2096-6339","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T22:40:57Z","timestamp":1687905657000},"page":"441-447","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of maternal serum hepassocin concentrations in pregnant\n                    women with gestational diabetes mellitus: a prospective case-control\n                    study"],"prefix":"10.1055","volume":"227","author":[{"given":"Aysegul","family":"Cakmak","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Umraniye Training and Research Hospital,\n                    Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-7199","authenticated-orcid":false,"given":"\u0130brahim","family":"Kale","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Umraniye Training and Research Hospital,\n                    Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Muhcu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Umraniye Training and Research Hospital,\n                    Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1097\/AOG.0000000000002501","article-title":"No. 190: Gestational Diabetes Mellitus","volume":"131","author":"ACOG Practice Bulletin","year":"2018","journal-title":"Obstet Gynecol"},{"key":"ref2","first-page":"278","article-title":"Cr\u0131ter\u0131a for the oral glucose tolerance test \u0131n\n                    pregnancy","volume":"13","author":"J B O\u2019sullivan","year":"1964","journal-title":"Diabetes"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"9573","DOI":"10.3390\/ijerph17249573","article-title":"Gestational diabetes: Overview with emphasis on medical management","volume":"17","author":"M Lende","year":"2020","journal-title":"Int J Environ Res Public Health"},{"volume-title":"IDF Diabetes Atlas 10th Edition Committee. IDF D\u0131abetes Atlas. 10th\n                    ed","year":"2021","author":"D J Magliano","key":"ref4"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1210\/endrev\/bnac003","article-title":"A clinical update on gestational diabetes mellitus","volume":"43","author":"A Sweeting","year":"2022","journal-title":"Endocr Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/5584_2020_512","volume-title":"Gestational Diabetes Mellitus Screening and Diagnosis. In: Islam MdS, ed.\n                    Diabetes: from Research to Clinical Practice","author":"U Y Sert","year":"2020"},{"key":"ref7","first-page":"1","article-title":"Screening and diagnosing gestational diabetes mellitus","author":"L Hartling","year":"2012","journal-title":"Evid Rep Technol Assess"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1080\/14767058.2019.1635109","article-title":"The prevalence and risk factors of gestational diabetes mellitus in Turkey: a\n                    systematic review and meta-analysis","volume":"34","author":"Z Kara\u00e7am","year":"2021","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e067946","DOI":"10.1136\/bmj-2021-067946","article-title":"Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review\n                    and meta-analysis","author":"W Ye","year":"2022","journal-title":"BMJ"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.soard.2017.11.031","article-title":"Hypoglycemia during oral glucose tolerance test among post\u2013bariatric\n                    surgery pregnant patients: incidence and perinatal significance","volume":"14","author":"A Rottenstreich","year":"2018","journal-title":"Surg Obes Relat Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1590\/2359-3997000000149","article-title":"Adverse effects during the oral glucose tolerance test in post-bariatric surgery\n                    patients","volume":"60","author":"H F Andrade","year":"2016","journal-title":"Arch Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0167-4781(00)00056-7","article-title":"Isolation and characterization of a novel liver-specific gene, hepassocin,\n                    upregulated during liver regeneration","volume":"1492","author":"H Hara","year":"2000","journal-title":"Biochim Biophys Acta BBA \u2013 Gene Struct Expr"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0167-4781(01)00249-4","article-title":"Molecular cloning and functional expression analysis of a cDNA for human\n                    hepassocin, a liver-specific protein with hepatocyte mitogenic activity","volume":"1520","author":"H Hara","year":"2001","journal-title":"Biochim Biophys Acta BBA \u2013 Gene Struct Expr"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.jhep.2013.06.004","article-title":"The role of hepassocin in the development of non-alcoholic fatty liver\n                    disease","volume":"59","author":"H-T Wu","year":"2013","journal-title":"J Hepatol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"255","DOI":"10.2217\/dmt.14.17","article-title":"Serum hepassocin concentrations in diabetic patients with or without\n                    nonalcoholic fatty liver disease","volume":"4","author":"F-H Lu","year":"2014","journal-title":"Diabetes Manag"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1007\/s00125-016-3991-7","article-title":"A novel hepatokine, HFREP1, plays a crucial role in the development of insulin\n                    resistance and type 2 diabetes","volume":"59","author":"H-T Wu","year":"2016","journal-title":"Diabetologia"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/biof.1574","article-title":"Discovery of a role of the novel hepatokine, hepassocin, in obesity","volume":"46","author":"R Huang","year":"2020","journal-title":"BioFactors"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"676","DOI":"10.2337\/dc09-1848","article-title":"International Association of Diabetes and Pregnancy Study Groups recommendations\n                    on the diagnosis and classification of hyperglycemia in pregnancy","volume":"33","author":"International Association of Diabetes and Pregnancy Study\n                            Groups Consensus Panel","year":"2010","journal-title":"Diabetes Care"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1016\/j.cellsig.2014.04.013","article-title":"Hepassocin activates the EGFR\/ERK cascade and induces proliferation of\n                    L02 cells through the Src-dependent pathway","volume":"26","author":"M Gao","year":"2014","journal-title":"Cell Signal"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.phrs.2012.04.005","article-title":"ERK1\/2 MAP kinases: Structure, function, and regulation","volume":"66","author":"R. Roskoski","year":"2012","journal-title":"Pharmacol Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.mce.2013.05.021","article-title":"Hepatic ERK activity plays a role in energy metabolism","volume":"375","author":"P Jiao","year":"2013","journal-title":"Mol Cell Endocrinol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1210\/jc.2016-3287","article-title":"The hepatic protection effects of hepassocin in hyperglycemic crisis","volume":"102","author":"H-Y Ou","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ejogrb.2021.10.034","article-title":"Do serum hepassocin levels change in women with polycystic ovary syndrome","volume":"267","author":"F Ketenci Gencer","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2096-6339.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T23:47:33Z","timestamp":1701215253000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2096-6339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":23,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2023,11,28]]},"published-print":{"date-parts":[[2023,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2096-6339","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"type":"print","value":"0948-2393"},{"type":"electronic","value":"1439-1651"}],"subject":[],"published":{"date-parts":[[2023,6,27]]}}}