{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:31:47Z","timestamp":1785515507970,"version":"3.56.0"},"reference-count":6,"publisher":"Georg Thieme Verlag KG","issue":"S 01","funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["1R01HD077592"],"award-info":[{"award-number":["1R01HD077592"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to characterize the relationship between maternal obesity, fetal abdominal size, and neonatal morbidity in pregnancies complicated by fetal growth restriction (FGR).<\/jats:p><jats:p>\n            Study Design\u2003Pregnancies complicated by FGR, which resulted in delivery of a live, singleton, nonanomalous infant at a single center between 2002 and 2013 were identified in a large, National Institutes of Health\u2013funded database of detailed pregnancy and delivery information extracted by trained research nurses. Pregnancies complicated by diabetes were excluded. Fetal biometry measurements from third trimester ultrasounds performed at the same institution were extracted from another institutional database. Pregnancies were divided into cohorts based on fetal abdominal circumference (AC) gestational age percentile (&lt;10th centile, 10\u201329th centile, 30\u201349th centile, and \u226550th centile) at the ultrasound closes to the date of delivery. Obesity was defined by prepregnancy body mass index &gt;30\u2009kg\/m2. The primary outcome was a composite of neonatal morbidity (CM) including 5-minute Apgar\u2009&lt;\u20097, arterial cord pH &lt;7.0, sepsis, respiratory support, chest compressions, phototherapy, exchange transfusion, hypoglycemia requiring treatment, or neonatal death. Outcomes were compared between women with versus without prepregnancy obesity overall and then stratified by AC cohort.<\/jats:p><jats:p>\n            Results\u2003A total of 379 pregnancies met criteria; CM occurred in 136 (36%). Overall, there was no difference in CM between infants born to women with versus without obesity (risk ratio (RR): 1.11, 95% confidence interval: 0.79\u20131.56). When stratified according to AC at ultrasound closest to delivery, there was higher prevalence of CM occurring among women with prepregnancy obesity than those without prepregnancy obesity when the fetal AC was &gt;50th or 30 to 49th centile However, these differences did not reach statistical significance.<\/jats:p><jats:p>\n            Conclusion\u2003Our study identified no significant difference in risk of CM among growth-restricted infants of obese versus nonobese mothers, including among infants with very small AC. More research is needed to further examine the potential relationships postulated here.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2099-4000","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T23:14:35Z","timestamp":1684970075000},"page":"e2184-e2187","source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["The Impact of Maternal Obesity on Neonatal Outcomes of Pregnancies Complicated by Fetal Growth Restriction"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9420-7456","authenticated-orcid":false,"given":"Anna R.","family":"Whelan","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Women & Infants Hospital of Rhode Island, Alpert Medical School of Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Esposito","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Women & Infants Hospital of Rhode Island, Alpert Medical School of Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan G.","family":"Lord","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Women & Infants Hospital of Rhode Island, Alpert Medical School of Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.3390\/nu13041213","article-title":"Maternal obesity and risk of low birth weight, fetal growth restriction, and macrosomia: multiple analyses","volume":"13","author":"M Lewandowska","year":"2021","journal-title":"Nutrients"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"R97","DOI":"10.1530\/REP-16-0495","article-title":"Effects of maternal obesity on placental function and fetal development","volume":"153","author":"K R Howell","year":"2017","journal-title":"Reproduction"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/birt.12246","article-title":"Impact of maternal body mass index on intrapartum and neonatal outcomes in Brisbane, Australia, 2007 to 2013","volume":"43","author":"X Y Foo","year":"2016","journal-title":"Birth"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"B2","DOI":"10.1016\/j.ajog.2020.05.010","article-title":"Society for Maternal-Fetal Medicine Consult Series #52: diagnosis and management of fetal growth restriction: (Replaces Clinical Guideline Number 3, April 2012)","volume":"223","author":"J G Martins","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/jcu.22273","article-title":"The effect of maternal obesity on sonographic fetal weight estimation and perinatal outcome in pregnancies complicated by fetal growth restriction","volume":"44","author":"F Cody","year":"2016","journal-title":"J Clin Ultrasound"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"j1","DOI":"10.1136\/bmj.j1","article-title":"Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child","volume":"356","author":"P M Catalano","year":"2017","journal-title":"BMJ"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2099-4000.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:51:07Z","timestamp":1730814667000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2099-4000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":6,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2099-4000","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,24]]},"published":{"date-parts":[[2023,5,24]]}}}