{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:02:43Z","timestamp":1789419763826,"version":"build-2803163510"},"reference-count":109,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endothelial colony-forming cells (ECFCs) are endothelial progenitor cells circulating in a limited number in peripheral blood. They can give rise to mature endothelial cells (ECs) and, with intrinsically high proliferative potency, contribute to forming new blood vessels and restoring the damaged endothelium in vivo. ECFCs can be isolated from peripheral blood or umbilical cord and cultured to generate large amounts of autologous ECs in vitro. Upon differentiation in culture, ECFCs are excellent surrogates for mature ECs showing the same phenotypic, genotypic, and functional features. In the last two decades, the ECFCs from various vascular disease patients have been widely used to study the diseases' pathophysiology ex vivo and develop cell-based therapeutic approaches, including vascular regenerative therapy, tissue engineering, and gene therapy. In the current review, we will provide an updated overview of past studies, which have used ECFCs to elucidate the molecular mechanisms underlying the pathogenesis of hemostatic disorders in basic research. Additionally, we summarize preceding studies demonstrating the utility of ECFCs as cellular tools for diagnostic or therapeutic clinical applications in thrombosis and hemostasis.<\/jats:p>","DOI":"10.1055\/a-2101-5936","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T22:36:51Z","timestamp":1697755011000},"page":"325-337","source":"Crossref","is-referenced-by-count":9,"title":["Potentials of Endothelial Colony-Forming Cells: Applications in Hemostasis and Thrombosis Disorders, from Unveiling Disease Pathophysiology to Cell Therapy"],"prefix":"10.1055","volume":"43","author":[{"given":"Nadine","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamideh","family":"Yadegari","sequence":"additional","affiliation":[{"name":"Institute of Experimental Hematology and 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clonal analysis and hematopoietic stem\/progenitor cell principals","volume":"109","author":"M C Yoder","year":"2007","journal-title":"Blood"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1111\/jth.14998","article-title":"Endothelial characteristics in healthy endothelial colony forming cells; generating a robust and valid ex vivo model for vascular disease","volume":"18","author":"S de Boer","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"07","key":"ref5","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1111\/jth.14462","article-title":"Standardization of methods to quantify and culture endothelial colony-forming cells derived from peripheral blood: position paper from the International Society on Thrombosis and Haemostasis SSC","volume":"17","author":"D M Smadja","year":"2019","journal-title":"J Thromb Haemost"},{"issue":"09","key":"ref6","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1182\/blood-2004-04-1396","article-title":"Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood","volume":"104","author":"D A Ingram","year":"2004","journal-title":"Blood"},{"issue":"07","key":"ref7","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1161\/ATVBAHA.107.144972","article-title":"Endothelial outgrowth cells are not derived from CD133+ cells or CD45+ hematopoietic precursors","volume":"27","author":"F Timmermans","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"07","key":"ref8","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1182\/blood-2004-08-3057","article-title":"Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells","volume":"105","author":"D A Ingram","year":"2005","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1755-8794-3-18","article-title":"Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities","volume":"3","author":"R J Medina","year":"2010","journal-title":"BMC Med Genomics"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1182\/blood-2006-12-062471","article-title":"In vivo vasculogenic potential of human blood-derived endothelial progenitor cells","volume":"109","author":"J M Melero-Martin","year":"2007","journal-title":"Blood"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1182\/blood-2007-06-094318","article-title":"Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels","volume":"111","author":"P Au","year":"2008","journal-title":"Blood"},{"issue":"07","key":"ref12","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1182\/blood-2003-08-2770","article-title":"Human endothelial cells derived from circulating progenitors display specific functional properties compared with mature vessel wall endothelial cells","volume":"103","author":"H Bompais","year":"2004","journal-title":"Blood"},{"issue":"05","key":"ref13","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/sctm.16-0360","article-title":"Endothelial progenitors: a consensus statement on nomenclature","volume":"6","author":"R J Medina","year":"2017","journal-title":"Stem Cells Transl Med"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/jth.14715","article-title":"Patients with aortic stenosis have von Willebrand factor abnormalities and increased proliferation of endothelial colony forming cells","volume":"18","author":"S N Selvam","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10456-014-9446-1","article-title":"Segregation of late outgrowth endothelial cells into functional endothelial CD34- and progenitor-like CD34+ cell populations","volume":"18","author":"C Ferreras","year":"2015","journal-title":"Angiogenesis"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/stem.1280","article-title":"Late outgrowth endothelial cells resemble mature endothelial cells and are not derived from bone marrow","volume":"31","author":"O Tura","year":"2013","journal-title":"Stem Cells"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12015-010-9157-y","article-title":"Transplanted late outgrowth endothelial progenitor cells as cell therapy product for stroke","volume":"7","author":"C Moubarik","year":"2011","journal-title":"Stem Cell Rev 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Asahara","year":"1997","journal-title":"Science"},{"issue":"01","key":"ref24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1172\/JCI8071","article-title":"Origins of circulating endothelial cells and endothelial outgrowth from blood","volume":"105","author":"Y Lin","year":"2000","journal-title":"J Clin Invest"},{"issue":"04","key":"ref25","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.biomaterials.2008.09.058","article-title":"Contribution of outgrowth endothelial cells from human peripheral blood on in vivo vascularization of bone tissue engineered constructs based on starch polycaprolactone scaffolds","volume":"30","author":"S Fuchs","year":"2009","journal-title":"Biomaterials"},{"issue":"12","key":"ref26","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1182\/blood-2005-09-3605","article-title":"Phenotypic correction of von Willebrand disease type 3 blood-derived endothelial cells with lentiviral vectors expressing von Willebrand 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Yadegari","year":"2016","journal-title":"Blood"},{"issue":"06","key":"ref45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/ijms23063095","article-title":"A homozygous deep intronic variant causes von Willebrand factor deficiency and lack of endothelial-specific secretory organelles, Weibel-Palade bodies","volume":"23","author":"H Yadegari","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"03","key":"ref46","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1182\/bloodadvances.2021005895","article-title":"Multifaceted pathomolecular mechanism of a VWF large deletion involved in the pathogenesis of severe VWD","volume":"6","author":"H Yadegari","year":"2022","journal-title":"Blood Adv"},{"issue":"04","key":"ref47","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1182\/blood-2015-10-678052","article-title":"Characterization of aberrant splicing of von Willebrand factor in von Willebrand disease: an underrecognized mechanism","volume":"128","author":"L Hawke","year":"2016","journal-title":"Blood"},{"issue":"07","key":"ref48","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/jth.13722","article-title":"Discrepant platelet and plasma von Willebrand factor in von Willebrand disease patients with p.Pro2808Leufs*24","volume":"15","author":"M L Bowman","year":"2017","journal-title":"J Thromb Haemost"},{"issue":"07","key":"ref49","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1111\/jth.15740","article-title":"von Willebrand factor propeptide variants lead to impaired storage and ER retention in patient-derived endothelial colony-forming cells","volume":"20","author":"M Bowman","year":"2022","journal-title":"J Thromb Haemost"},{"issue":"08","key":"ref50","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1111\/jth.15746","article-title":"VWF-Gly2752Ser, a novel non-cysteine substitution variant in the CK domain, exhibits severe secretory impairment by hampering C-terminal dimer formation","volume":"20","author":"S Okamoto","year":"2022","journal-title":"J Thromb Haemost"},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1111\/j.1538-7836.2009.03551.x","article-title":"An assessment of the pathogenic significance of the R924Q von Willebrand factor substitution","volume":"7","author":"E Berber","year":"2009","journal-title":"J Thromb Haemost"},{"issue":"04","key":"ref52","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/rth2.12242","article-title":"Alternative trafficking of Weibel-Palade body proteins in CRISPR\/Cas9-engineered von Willebrand factor-deficient blood outgrowth endothelial cells","volume":"3","author":"M Schillemans","year":"2019","journal-title":"Res Pract Thromb Haemost"},{"issue":"08","key":"ref53","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1182\/bloodadvances.2022007884","article-title":"A transcriptome analysis of basal and stimulated VWF release from endothelial cells derived from type 1 VWD patients","volume":"7","author":"R Kloosterman","year":"2023","journal-title":"Blood Adv"},{"issue":"03","key":"ref54","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/j.1582-4934.2008.00161.x","article-title":"Thrombin bound to a fibrin clot confers angiogenic and haemostatic properties on endothelial progenitor cells","volume":"12","author":"D M Smadja","year":"2008","journal-title":"J Cell Mol Med"},{"issue":"01","key":"ref55","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/ATVBAHA.122.318433","article-title":"Ex vivo modeling of the PC (protein C) pathway using endothelial cells and plasma: a personalized approach","volume":"43","author":"N Schwarz","year":"2023","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"09","key":"ref56","first-page":"2742","article-title":"The relationship between the levels and function of endothelial progenitor cells and factor V Leiden and protein C deficiency in patients with primary Budd-Chiari syndrome","volume":"22","author":"Z-Y Guan","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"06","key":"ref57","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nrrheum.2009.81","article-title":"Endothelial progenitor cell dysfunction in rheumatic disease","volume":"5","author":"P E Westerweel","year":"2009","journal-title":"Nat Rev Rheumatol"},{"issue":"07","key":"ref58","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1080\/08916930903002479","article-title":"Premature vascular damage in systemic lupus erythematosus","volume":"42","author":"M J Kaplan","year":"2009","journal-title":"Autoimmunity"},{"issue":"01","key":"ref59","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1365-2141.2001.03076.x","article-title":"Increased apoptosis of bone marrow CD34(+) cells and impaired function of bone marrow stromal cells in patients with systemic lupus erythematosus","volume":"115","author":"H A Papadaki","year":"2001","journal-title":"Br J Haematol"},{"issue":"08","key":"ref60","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1182\/blood-2007-05-089086","article-title":"Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis","volume":"110","author":"M F Denny","year":"2007","journal-title":"Blood"},{"issue":"07","key":"ref61","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1136\/ard.2006.065631","article-title":"Haematopoietic and endothelial progenitor cells are deficient in quiescent systemic lupus erythematosus","volume":"66","author":"P E Westerweel","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"ref62","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1093\/rheumatology\/ken299","article-title":"Endothelial progenitor cells and colony-forming units in rheumatoid arthritis: association with clinical characteristics","volume":"47","author":"C G Egan","year":"2008","journal-title":"Rheumatology (Oxford)"},{"issue":"07","key":"ref63","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.4049\/jimmunol.1001782","article-title":"The detrimental effects of IFN-\u03b1 on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction","volume":"185","author":"S G Thacker","year":"2010","journal-title":"J Immunol"},{"issue":"11","key":"ref64","doi-asserted-by":"crossref","first-page":"6143","DOI":"10.4049\/jimmunol.1101284","article-title":"Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus","volume":"187","author":"J M Kahlenberg","year":"2011","journal-title":"J Immunol"},{"issue":"08","key":"ref65","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/art.39149","article-title":"Endothelial progenitor cell phenotype and function are impaired in childhood-onset systemic lupus erythematosus","volume":"67","author":"S Mohan","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"03","key":"ref66","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.thromres.2008.05.015","article-title":"Patients with primary antiphospholipid antibody syndrome and without associated vascular risk factors present a normal endothelial function","volume":"123","author":"P Gresele","year":"2009","journal-title":"Thromb Res"},{"issue":"02","key":"ref67","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1136\/annrheumdis-2016-209442","article-title":"Endothelial progenitor dysfunction associates with a type I interferon signature in primary antiphospholipid syndrome","volume":"76","author":"R C Grenn","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"ref68","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.3324\/haematol.2009.013672","article-title":"Hypercoagulability and thrombotic complications in hemolytic anemias","volume":"94","author":"K I Ataga","year":"2009","journal-title":"Haematologica"},{"issue":"07","key":"ref69","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1182\/blood-2007-06-097188","article-title":"Genetic endothelial systems biology of sickle stroke risk","volume":"111","author":"L Chang Milbauer","year":"2008","journal-title":"Blood"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.mvr.2013.10.002","article-title":"Increased adhesive and inflammatory properties in blood outgrowth endothelial cells from sickle cell anemia patients","volume":"90","author":"T M Sakamoto","year":"2013","journal-title":"Microvasc Res"},{"issue":"03","key":"ref71","doi-asserted-by":"crossref","first-page":"e014143","DOI":"10.1161\/JAHA.119.014143","article-title":"Angiogenesis-Related Genes in Endothelial Progenitor Cells May Be Involved in Sickle Cell Stroke","volume":"9","author":"M T Ito","year":"2020","journal-title":"J Am Heart Assoc"},{"issue":"07","key":"ref72","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1055\/s-0040-1715456","article-title":"COVID-19 and venous thromboembolism: a meta-analysis of literature studies","volume":"46","author":"A Di Minno","year":"2020","journal-title":"Semin Thromb Hemost"},{"issue":"04","key":"ref73","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1007\/s11239-020-02235-z","article-title":"Venous thromboembolism in critically ill COVID-19 patients receiving prophylactic or therapeutic anticoagulation: a systematic review and meta-analysis","volume":"50","author":"S S Hasan","year":"2020","journal-title":"J Thromb Thrombolysis"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.amjcard.2022.01.051","article-title":"Prevalence of acute pulmonary embolism at autopsy in patients with COVID-19","volume":"171","author":"M Zuin","year":"2022","journal-title":"Am J 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Margheri","year":"2011","journal-title":"Blood"},{"issue":"02","key":"ref78","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s12015-017-9778-5","article-title":"Endothelial microparticles are associated to pathogenesis of idiopathic pulmonary fibrosis","volume":"14","author":"N C Bacha","year":"2018","journal-title":"Stem Cell Rev Rep"},{"issue":"04","key":"ref79","doi-asserted-by":"crossref","first-page":"H1784","DOI":"10.1152\/ajpheart.2001.281.4.H1784","article-title":"Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis","volume":"281","author":"S Brodsky","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"08","key":"ref80","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1046\/j.1538-7836.2003.00182.x","article-title":"The role of plasminogen in angiogenesis in vivo","volume":"1","author":"C-W Oh","year":"2003","journal-title":"J Thromb Haemost"},{"issue":"07","key":"ref81","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1182\/blood-2007-02-069997","article-title":"Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro","volume":"110","author":"R Lacroix","year":"2007","journal-title":"Blood"},{"issue":"01","key":"ref82","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13287-017-0764-2","article-title":"The role of fibrinolysis inhibition in engineered vascular networks derived from endothelial cells and adipose-derived stem cells","volume":"9","author":"S M\u00fchleder","year":"2018","journal-title":"Stem Cell Res Ther"},{"issue":"04","key":"ref83","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1055\/s-0034-1389261","article-title":"Changes of number and function of late endothelial progenitor cells in peripheral blood of COPD patients combined with pulmonary hypertension","volume":"64","author":"P Liu","year":"2016","journal-title":"Thorac Cardiovasc Surg"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11010-011-1157-y","article-title":"Human endothelial progenitor cells isolated from COPD patients are dysfunctional","volume":"363","author":"X Liu","year":"2012","journal-title":"Mol Cell Biochem"},{"issue":"02","key":"ref85","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10456-018-09659-5","article-title":"Interleukin-8 release by endothelial colony-forming cells isolated from idiopathic pulmonary fibrosis patients might contribute to their pathogenicity","volume":"22","author":"A Blandini\u00e8res","year":"2019","journal-title":"Angiogenesis"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-3-030-31206-0_11","article-title":"Vasculogenic stem and progenitor cells in human: future cell therapy product or liquid biopsy for vascular disease","volume":"1201","author":"D M Smadja","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.thromres.2015.11.005","article-title":"Endothelial colony-forming cells: biological and functional abnormalities in patients with recurrent, unprovoked venous thromboembolic disease","volume":"137","author":"J A Alvarado-Moreno","year":"2016","journal-title":"Thromb Res"},{"issue":"12","key":"ref88","doi-asserted-by":"crossref","first-page":"e15277","DOI":"10.1371\/journal.pone.0015277","article-title":"High frequency of endothelial colony forming cells marks a non-active myeloproliferative neoplasm with high risk of splanchnic vein thrombosis","volume":"5","author":"V Rosti","year":"2010","journal-title":"PLoS One"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"100218","DOI":"10.1016\/j.eclinm.2019.11.011","article-title":"Patients with high levels of circulating endothelial progenitor cells (EPC) following at least three months of anticoagulation for unprovoked venous thromboembolism (VTE) are at low risk of recurrent VTE-Results from the ExACT randomised controlled trial","volume":"17","author":"C Bradbury","year":"2019","journal-title":"EClinicalMedicine"},{"issue":"05","key":"ref90","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1089\/ten.teb.2016.0050","article-title":"Therapeutic potential of human-derived endothelial colony-forming cells in animal models","volume":"22","author":"D Tasev","year":"2016","journal-title":"Tissue Eng Part B Rev"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3389\/fmed.2018.00295","article-title":"Recent advances in endothelial colony forming cells toward their use in clinical translation","volume":"5","author":"K E Paschalaki","year":"2018","journal-title":"Front Med (Lausanne)"},{"issue":"11","key":"ref92","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1055\/s-0040-1715442","article-title":"Ex vivo improvement of a von Willebrand disease type 2A phenotype using an allele-specific small-interfering RNA","volume":"120","author":"A de Jong","year":"2020","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref93","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13287-019-1138-8","article-title":"Potential long-term treatment of hemophilia A by neonatal co-transplantation of cord blood-derived endothelial colony-forming cells and placental mesenchymal stromal cells","volume":"10","author":"K Gao","year":"2019","journal-title":"Stem Cell Res Ther"},{"issue":"10","key":"ref94","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1634\/stemcells.2006-0699","article-title":"Ex vivo gene therapy for hemophilia A that enhances safe delivery and sustained in vivo factor VIII expression from lentivirally engineered endothelial progenitors","volume":"25","author":"H Matsui","year":"2007","journal-title":"Stem Cells"},{"issue":"26","key":"ref95","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1182\/blood-2013-12-545780","article-title":"Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response","volume":"123","author":"M C Ozelo","year":"2014","journal-title":"Blood"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"678117","DOI":"10.3389\/fcell.2021.678117","article-title":"Investigating optimal autologous cellular platforms for prenatal or perinatal factor VIII delivery to treat hemophilia A","volume":"9","author":"C Stem","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"04","key":"ref97","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41569-018-0118-5","article-title":"Predictors of stent thrombosis and their implications for clinical practice","volume":"16","author":"T Gori","year":"2019","journal-title":"Nat Rev Cardiol"},{"issue":"05","key":"ref98","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/eurheartj\/ehi618","article-title":"Incidence, predictors, and outcomes of coronary dissections left untreated after drug-eluting stent implantation","volume":"27","author":"G GL Biondi-Zoccai","year":"2006","journal-title":"Eur Heart J"},{"issue":"13","key":"ref99","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1016\/S0142-9612(03)00042-5","article-title":"Fabrication of endothelial progenitor cell (EPC)-seeded intravascular stent devices and in vitro endothelialization on hybrid vascular tissue","volume":"24","author":"T Shirota","year":"2003","journal-title":"Biomaterials"},{"issue":"10","key":"ref100","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.jacc.2005.01.048","article-title":"Endothelial progenitor cell capture by stents coated with antibody against CD34: the HEALING-FIM (Healthy Endothelial 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