{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T04:10:08Z","timestamp":1700799008728},"reference-count":71,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die optimale Therapie von duodenopankreatischen neuroendokrinen Neoplasien (dpNEN), die im Rahmen der multiplen endokrinen Neoplasie Typ 1 auftreten, stellt nach wie vor eine gro\u00dfe\n          Herausforderung dar und wird teilweise kontrovers diskutiert. Aufgrund der Rarit\u00e4t der Erkrankung fehlen prospektiv randomisierte Studien, sodass die meisten Empfehlungen bez. der\n          Operationsindikation und des -verfahrens auf retrospektiven Fallserien basieren. Prinzipiell ist eine operative Therapie bei nicht funktionellen dpNEN &gt;\u00a02\u00a0cm, bei Malignit\u00e4tsverdacht und\n          bei funktionell aktiven dpNEN indiziert. Hierbei kommen eine Enukleation oder formale Pankreasresektionen mit oder ohne Lymphadenektomie in Betracht. Ziel der Therapie sollte es sein,\n          hormonassoziierte Symptome zu beseitigen und einem aggressiven metastasierenden Verlauf vorzubeugen. Zugleich sollte bei den zumeist jungen Patienten die Pankreasfunktion und Lebensqualit\u00e4t\n          durch m\u00f6glichst parenchymsparende Resektionen erhalten werden.<\/jats:p>","DOI":"10.1055\/a-2103-3525","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T18:49:47Z","timestamp":1692643787000},"page":"483-491","source":"Crossref","is-referenced-by-count":0,"title":["Indikation und operative Verfahren bei MEN1-assoziierten duodenopankreatischen neuroendokrinen Neoplasien"],"prefix":"10.1055","volume":"148","author":[{"given":"Jerena","family":"Manoharan","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Visceral-, Thorax- und Gef\u00e4\u00dfchirurgie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg - Standort Marburg, Marburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Albers","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Visceral-, Thorax- und Gef\u00e4\u00dfchirurgie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg - Standort Marburg, Marburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlef K","family":"Bartsch","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Visceral-, Thorax- und Gef\u00e4\u00dfchirurgie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg - Standort Marburg, Marburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"F1000","DOI":"10.12688\/f1000research.7230.1","article-title":"Genetics of multiple endocrine neoplasia type 1 syndrome: what\u2019s new and what\u2019s old","volume":"6","author":"A Falchetti","year":"2017","journal-title":"F1000Research"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1007\/s00268-017-3992-9","article-title":"Is Routine Screening of Young Asymptomatic MEN1 Patients Necessary?","volume":"41","author":"J Manoharan","year":"2017","journal-title":"World J Surg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1126\/science.276.5311.404","article-title":"Positional cloning of the gene for multiple endocrine neoplasia-type 1","volume":"276","author":"SC Chandrasekharappa","year":"1997","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/humu.20605","article-title":"Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene","volume":"29","author":"MC Lemos","year":"2008","journal-title":"Hum Mutat"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2217\/ije15.17","article-title":"Controversies in surgery for multiple endocrine neoplasia type 1-associated Zollinger-Ellison syndrome","author":"DK Bartsch","year":"2015","journal-title":"Int J Endocrin Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.3390\/CANCERS14081928","article-title":"Pancreaticoduodenectomy Is the Best Surgical Procedure for Zollinger-Ellison Syndrome Associated with Multiple Endocrine Neoplasia Type 1","volume":"14","author":"W Kong","year":"2022","journal-title":"Cancers (Basel)"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-662-61724-3_45-1","volume-title":"Heredit\u00e4re duodenopankreatische neuroendokrine Neoplasien","author":"MB Albers","year":"2022"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00268-009-0290-1","article-title":"Risk factors and causes of death in MEN1 disease. 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