{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:25:07Z","timestamp":1788546307642,"version":"build-2803163510"},"reference-count":86,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"Hickam Endowed Chair, Gastroenterology, Medicine, Indiana University, the Indiana University Health \u2013 Indiana University School of Medicine Strategic Research Initiative","award":["IK6BX005226"],"award-info":[{"award-number":["IK6BX005226"]}]},{"name":"Hickam Endowed Chair, Gastroenterology, Medicine, Indiana University, the Indiana University Health \u2013 Indiana University School of Medicine Strategic Research Initiative","award":["IK6BX005226"],"award-info":[{"award-number":["IK6BX005226"]}]},{"name":"Hickam Endowed Chair, Gastroenterology, Medicine, Indiana University, the Indiana University Health \u2013 Indiana University School of Medicine Strategic Research Initiative","award":["1I01BX003031"],"award-info":[{"award-number":["1I01BX003031"]}]},{"name":"United States Department of Veteran's Affairs, Biomedical Laboratory Research and Development Service","award":["DK108959"],"award-info":[{"award-number":["DK108959"]}]},{"name":"United States Department of Veteran's Affairs, Biomedical Laboratory Research and Development Service","award":["DK119421"],"award-info":[{"award-number":["DK119421"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Liver Dis"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Mast cells (MCs) contribute to the pathogenesis of cholestatic liver diseases (primary sclerosing cholangitis [PSC] and primary biliary cholangitis [PBC]). PSC and PBC are immune-mediated, chronic inflammatory diseases, characterized by bile duct inflammation and stricturing, advancing to hepatobiliary cirrhosis. MCs are tissue resident immune cells that may promote hepatic injury, inflammation, and fibrosis formation by either direct or indirect interactions with other innate immune cells (neutrophils, macrophages\/Kupffer cells, dendritic cells, natural killer, and innate lymphoid cells). The activation of these innate immune cells, usually through the degranulation of MCs, promotes antigen uptake and presentation to adaptive immune cells, exacerbating liver injury. In conclusion, dysregulation of MC-innate immune cell communications during liver injury and inflammation can lead to chronic liver injury and cancer.<\/jats:p>","DOI":"10.1055\/a-2104-9034","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T23:09:17Z","timestamp":1685747357000},"page":"226-233","source":"Crossref","is-referenced-by-count":12,"title":["Mast Cell and Innate Immune Cell Communication in Cholestatic Liver Disease"],"prefix":"10.1055","volume":"43","author":[{"given":"Jessica K.","family":"Bernard","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinn","family":"Marakovits","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah G.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Francis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana"},{"name":"Department of Research, Richard L. 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large cholangiocytes during biliary injury via H2HR-mediated cAMP\/pERK1\/2 signaling","volume":"6","author":"T Zhou","year":"2022","journal-title":"Hepatol Commun"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"165557","DOI":"10.1016\/j.bbadis.2019.165557","article-title":"Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage\/senescence and liver fibrosis in Mdr2-\/- mice","volume":"1865","author":"V Meadows","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1002\/hep.29079","article-title":"Bile duct ligation-induced biliary hyperplasia, hepatic injury, and fibrosis are reduced in mast cell-deficient KitW-sh mice","volume":"65","author":"L Hargrove","year":"2017","journal-title":"Hepatology"},{"issue":"02","key":"ref11","doi-asserted-by":"crossref","first-page":"G89","DOI":"10.1152\/ajpgi.00333.2016","article-title":"The emerging role of mast cells in liver disease","volume":"313","author":"V Jarido","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/hep.28704","article-title":"Inhibition of mast cell-secreted histamine decreases biliary proliferation and fibrosis in primary sclerosing cholangitis Mdr2(-\/-) mice","volume":"64","author":"H Jones","year":"2016","journal-title":"Hepatology"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/labinvest.2014.129","article-title":"Inhibition of mast cell-derived histamine secretion by cromolyn sodium treatment decreases biliary hyperplasia in cholestatic rodents","volume":"94","author":"L L Kennedy","year":"2014","journal-title":"Lab Invest"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/hep.32121","article-title":"Mast cells in liver disease progression: an update on current studies and implications","volume":"75","author":"L Pham","year":"2022","journal-title":"Hepatology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"964887","DOI":"10.3389\/fphys.2022.964887","article-title":"Exploring the role of mast cells in the progression of liver disease","volume":"13","author":"S Huang","year":"2022","journal-title":"Front Physiol"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.3390\/cells9122538","article-title":"Mast cell functions linking innate sensing to adaptive immunity","volume":"9","author":"K 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Pejler","year":"2022","journal-title":"J Innate Immun"},{"issue":"05","key":"ref27","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.cell.2022.01.010","article-title":"GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA","volume":"185","author":"M De Giovanni","year":"2022","journal-title":"Cell"},{"issue":"01","key":"ref28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41423-020-00560-0","article-title":"Neutrophils in liver diseases: pathogenesis and therapeutic targets","volume":"18","author":"K Liu","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"625472","DOI":"10.3389\/fimmu.2021.625472","article-title":"The roles of neutrophils in the pathogenesis of liver diseases","volume":"12","author":"J Tang","year":"2021","journal-title":"Front 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Takeuchi","year":"2021","journal-title":"Gut"},{"issue":"28","key":"ref33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1126\/sciimmunol.aar7754","article-title":"Type 3 cytokines IL-17A and IL-22 drive TGF-\u03b2-dependent liver fibrosis","volume":"3","author":"T Fabre","year":"2018","journal-title":"Sci Immunol"},{"issue":"03","key":"ref34","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.2353\/ajpath.2010.090527","article-title":"Neutrophil depletion blocks early collagen degradation in repairing cholestatic rat livers","volume":"176","author":"M W Harty","year":"2010","journal-title":"Am J Pathol"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1172\/JCI122258","article-title":"Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223","volume":"129","author":"C J Calvente","year":"2019","journal-title":"J Clin 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Hepatol"},{"issue":"03","key":"ref45","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jhep.2018.05.018","article-title":"Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice","volume":"69","author":"M E Guicciardi","year":"2018","journal-title":"J Hepatol"},{"issue":"03","key":"ref46","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0092-8674(01)00456-1","article-title":"Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity","volume":"106","author":"Y J Liu","year":"2001","journal-title":"Cell"},{"issue":"07","key":"ref47","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/89726","article-title":"Dendritic cell lineage, plasticity and cross-regulation","volume":"2","author":"Y J Liu","year":"2001","journal-title":"Nat Immunol"},{"issue":"07","key":"ref48","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.4049\/jimmunol.167.7.3682","article-title":"Histamine polarizes human dendritic cells into Th2 cell-promoting effector dendritic cells","volume":"167","author":"G Caron","year":"2001","journal-title":"J Immunol"},{"issue":"06","key":"ref49","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.4049\/jimmunol.177.6.3577","article-title":"Dendritic cell modulation by mast cells controls the Th1\/Th2 balance in responding T cells","volume":"177","author":"A Mazzoni","year":"2006","journal-title":"J Immunol"},{"issue":"07","key":"ref50","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.4049\/jimmunol.176.7.4102","article-title":"Mast cell-associated TNF promotes dendritic cell migration","volume":"176","author":"H Suto","year":"2006","journal-title":"J Immunol"},{"issue":"04","key":"ref51","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.chom.2009.09.004","article-title":"Mast cells augment adaptive immunity by orchestrating dendritic cell trafficking through infected tissues","volume":"6","author":"C P Shelburne","year":"2009","journal-title":"Cell Host Microbe"},{"issue":"04","key":"ref52","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.4049\/jimmunol.0803894","article-title":"Mast cells, histamine, and IL-6 regulate the selective influx of dendritic cell subsets into an inflamed lymph node","volume":"184","author":"W Dawicki","year":"2010","journal-title":"J Immunol"},{"issue":"03","key":"ref53","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000242359","article-title":"Mast cells induce migration of dendritic cells in a murine model of acute allergic airway disease","volume":"151","author":"S Reuter","year":"2010","journal-title":"Int Arch Allergy Immunol"},{"issue":"04","key":"ref54","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.immuni.2011.09.012","article-title":"Mast cells condition dendritic cells to mediate allograft tolerance","volume":"35","author":"V C de Vries","year":"2011","journal-title":"Immunity"},{"issue":"06","key":"ref55","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.4049\/jimmunol.170.6.3037","article-title":"Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo","volume":"170","author":"D Skokos","year":"2003","journal-title":"J Immunol"},{"issue":"05","key":"ref56","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1083\/jcb.201412074","article-title":"Mast cells and dendritic cells form synapses that facilitate antigen transfer for T cell activation","volume":"210","author":"A Carroll-Portillo","year":"2015","journal-title":"J Cell Biol"},{"issue":"11","key":"ref57","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1471-4906(01)02060-9","article-title":"The biology of human natural killer-cell subsets","volume":"22","author":"M A Cooper","year":"2001","journal-title":"Trends Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev.immunol.17.1.189","article-title":"Natural killer cells in antiviral defense: function and regulation by innate cytokines","volume":"17","author":"C A Biron","year":"1999","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"ref59","doi-asserted-by":"crossref","first-page":"9248","DOI":"10.1128\/jvi.71.12.9248-9258.1997","article-title":"Mechanisms for virus-induced liver disease: tumor necrosis factor-mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection","volume":"71","author":"J S Orange","year":"1997","journal-title":"J Virol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"946","DOI":"10.3389\/fimmu.2019.00946","article-title":"Hepatic natural killer cells: organ-specific sentinels of liver immune homeostasis and physiopathology","volume":"10","author":"J Mikulak","year":"2019","journal-title":"Front 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Shimoda","year":"2011","journal-title":"Hepatology"},{"issue":"04","key":"ref64","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.4049\/jimmunol.176.4.2272","article-title":"Human mast cells undergo TRAIL-induced apoptosis","volume":"176","author":"B Berent-Maoz","year":"2006","journal-title":"J Immunol"},{"issue":"02","key":"ref65","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/hep.21035","article-title":"Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans","volume":"43","author":"K Ishiyama","year":"2006","journal-title":"Hepatology"},{"issue":"01","key":"ref66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10238-008-0149-z","article-title":"Characterisation of TNF-related apoptosis-inducing ligand in peripheral blood in patients with primary biliary cirrhosis","volume":"8","author":"Y Liang","year":"2008","journal-title":"Clin Exp 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Immunol"},{"issue":"04","key":"ref70","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/hep.24190","article-title":"Suppression of innate immunity (natural killer cell\/interferon-\u03b3) in the advanced stages of liver fibrosis in mice","volume":"53","author":"W I Jeong","year":"2011","journal-title":"Hepatology"},{"issue":"05","key":"ref71","first-page":"219","article-title":"EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model","volume":"219","author":"X Tao","year":"2022","journal-title":"J Exp Med"},{"issue":"09","key":"ref72","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nri3726","article-title":"Interactions between innate and adaptive lymphocytes","volume":"14","author":"G Gasteiger","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"03","key":"ref73","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/cmi.2013.9","article-title":"NK cells in immunotolerant organs","volume":"10","author":"H Sun","year":"2013","journal-title":"Cell Mol Immunol"},{"issue":"05","key":"ref74","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1182\/blood-2013-11-427781","article-title":"Human innate lymphoid cells","volume":"124","author":"M D Hazenberg","year":"2014","journal-title":"Blood"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/17812","article-title":"Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2","volume":"397","author":"Y Yokota","year":"1999","journal-title":"Nature"},{"issue":"06","key":"ref76","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/icb.2013.24","article-title":"Group 2 innate lymphoid cells show up in the skin","volume":"91","author":"H Spits","year":"2013","journal-title":"Immunol Cell Biol"},{"issue":"01","key":"ref77","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ni.1962","article-title":"The 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