{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T12:41:06Z","timestamp":1696941666296},"reference-count":47,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to investigate immune-related candidate genes for predicting the\n                    severity of acute pancreatitis (AP). RNA sequencing profile GSE194331 was\n                    downloaded, and differentially expressed genes (DEGs) were investigated.\n                    Meanwhile, the infiltration of immune cells in AP were assessed using CIBERSORT.\n                    Genes related with the infiltration of immune cells were investigated using\n                    weighted gene co-expression network analysis (WGCNA). Furthermore, immune\n                    subtypes, micro-environment, and DEGs between immune subtypes were explored.\n                    Immune-related genes, protein-protein interaction (PPI) network, and functional\n                    enrichment analysis were further performed. Overall, 2533 DEGs between AP and\n                    healthy controls were obtained. After trend cluster analysis, 411 upregulated\n                    and 604 downregulated genes were identified. Genes involved in two modules were\n                    significantly positively related to neutrophils and negatively associated with T\n                    cells CD4 memory resting, with correlation coefficient more than 0.7. Then, 39\n                    common immune-related genes were obtained, and 56 GO BP were enriched these\n                    genes, including inflammatory response, immune response, and innate immune\n                    response; 10 KEGG pathways were enriched, including cytokine-cytokine receptor\n                    interaction, Th1 and Th2 cell differentiation, and IL-17 signaling pathway.\n                    Genes, including S100A12, MMP9, IL18, S100A8, HCK, S100A9, RETN, OSM, FGR, CAMP,\n                    were selected as genes with top 10 degree in PPI, and the expression levels of\n                    these genes increased gradually in subjects of healthy, mild, moderately severe,\n                    and severe AP. Our findings indicate a central role of immune-related genes in\n                    predicting the severity of AP, and the hub genes involved in PPI represent\n                    logical candidates for further study.<\/jats:p>","DOI":"10.1055\/a-2105-6152","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T23:19:03Z","timestamp":1688167143000},"page":"711-721","source":"Crossref","is-referenced-by-count":0,"title":["Immune-Related Genes can Serve as Potential Biomarkers for Predicting\n                    Severe Acute Pancreatitis"],"prefix":"10.1055","volume":"55","author":[{"given":"Weijuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Emergency, Affiliated Wuxi Fifth Hospital of Jiangnan University\n                    (Infectious Diseases Hospital of Wuxi), Wuxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41575-018-0087-5","article-title":"Global epidemiology and holistic prevention of pancreatitis","volume":"16","author":"M S Petrov","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1016\/S0140-6736(17)32129-3","article-title":"Worldwide trends in body-mass index, underweight, overweight, and obesity from\n                    1975 to 2016: a pooled analysis of 2416 population-based measurement studies in\n                    128.9 million children, adolescents, and adults","volume":"390","author":"Collaboration NCDRF","year":"2017","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/MPA.0000000000000783","article-title":"The changing 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2105-6152.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:58:06Z","timestamp":1696895886000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2105-6152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,30]]},"references-count":47,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10,9]]},"published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2105-6152","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,30]]}}}