{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:10Z","timestamp":1740126850746,"version":"3.37.3"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"11","funder":[{"name":"UT Southwestern Medical Center","award":["George L. MacGregor Professorship"],"award-info":[{"award-number":["George L. MacGregor Professorship"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>\n            Objective\u2003The aim of this study was to determine which late-preterm (35\u201336 weeks' gestational age [GA]) and term neonates with early-onset hypoglycemia in the first 72\u2009hours postnatal required a continuous glucose infusion to achieve and successfully maintain euglycemia.<\/jats:p><jats:p>\n            Study Design\u2003This is a retrospective cohort study of late preterm and term neonates born in 2010\u20132014 and admitted to the Mother-Baby Unit at Parkland Hospital who had laboratory-proven blood glucose concentration\u2009&lt;\u200940\u2009mg\/dL (2.2\u2009mmol\/L) during the first 72\u2009hours of life. Among the subgroup needing intravenous (IV) glucose infusion, we analyzed which factors predicted a maximum glucose infusion rate (GIR) \u2265 10\u2009mg\/kg\/min. The entire cohort was randomly divided into a derivation cohort (n\u2009=\u20091,288) and a validation cohort (n\u2009=\u20091,298).<\/jats:p><jats:p>\n            Results\u2003In multivariate analysis, the need for IV glucose infusion was associated with small size for GA, low initial glucose concentration, early-onset infection, and other perinatal variables in both cohorts. A GIR \u2265 10\u2009mg\/kg\/min was required in 14% of neonates with blood glucose value\u2009&lt;\u200920\u2009mg\/dL during the first 3\u2009hours of observation. The likelihood of a GIR \u2265 10\u2009mg\/kg\/min was associated with lower initial blood glucose value and lower umbilical arterial pH.<\/jats:p><jats:p>\n            Conclusion\u2003Need for IV glucose infusion was associated with small size for GA, low initial glucose concentration, early-onset infection, and variables associated with perinatal hypoxia\u2013asphyxia. The likelihood of a maximum GIR \u2265 10\u2009mg\/kg\/min was greater in neonates with lower blood glucose value during the first 3\u2009hours of observation and lower umbilical arterial pH.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2107-1985","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T23:25:31Z","timestamp":1686180331000},"page":"1484-1494","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated with Need for Intravenous Glucose Infusion for the Treatment of Early Neonatal Hypoglycemia in Late Preterm and Term Neonates"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-0132","authenticated-orcid":false,"given":"Luc P.","family":"Brion","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Scheid","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L Steven","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Research, Parkland Health and Hospital System, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patti J.","family":"Burchfield","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9208-6539","authenticated-orcid":false,"given":"Charles R.","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,7,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1542\/pir.20.7.e6","article-title":"Neonatal hypoglycemia","volume":"20","author":"J E McGowan","year":"1999","journal-title":"Pediatr Rev"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1542\/peds.105.5.1141","article-title":"Controversies regarding definition of neonatal hypoglycemia: suggested operational thresholds","volume":"105","author":"M Cornblath","year":"2000","journal-title":"Pediatrics"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.jpeds.2012.05.022","article-title":"Incidence of neonatal hypoglycemia in babies identified as at risk","volume":"161","author":"D L 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