{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:12:07Z","timestamp":1787062327032,"version":"build-2736575974"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Dieser Fallbericht beschreibt indurative Mastitis in einer Schafherde als Folge\n                    einer Maedi-Visna-Virus (MVV)-Infektion. Mangelndes Aufeutern und kleine\n                    verh\u00e4rtete Euter nach dem Ablammen sowie vermehrt L\u00e4mmerverluste\n                    wurden in einer Herde Dorperschafe beobachtet. Die Befunde an Euter und Milch\n                    waren nicht charakteristisch f\u00fcr eine chronische bakterielle Mastitis.\n                    Die ungen\u00fcgende Eiwei\u00dfversorgung der Mutterschafe kann zu einer\n                    verringerten Milchmenge, aber nicht zu den verh\u00e4rteten Eutern\n                    gef\u00fchrt haben. Neunzehn der 21 Mutterschafe waren positiv f\u00fcr\n                    MVV-Antik\u00f6rper. Euter und Euterlymphknoten eines Schafes mit\n                    verh\u00e4rtetem Euter wurden anl\u00e4sslich der Schlachtung entnommen.\n                    Bei der Fleischbeschau wurden keine weiteren Organver\u00e4nderungen\n                    festgestellt. Die eine Euterh\u00e4lfte zeigte eine gering- bis mittelgradige\n                    multifokale lymphohistiozyt\u00e4re Mastitis, die andere eine hochgradige\n                    diffuse lymphohistiozyt\u00e4re Mastitis mit Atrophie des\n                    Dr\u00fcsengewebes, Vaskulopathie, Fibrose und Verkalkung. MVV-Antigen war\n                    immunhistologisch in Makrophagen, dendritischen Zellen, Epithelzellen und\n                    Endothelzellen der Milchdr\u00fcse sowie in Makrophagen und dendritischen\n                    Zellen der Euterlymphknoten zu finden. MVV-Provirusabschnitte konnten in den\n                    Euterlymphknoten und der st\u00e4rker ver\u00e4nderten Euterh\u00e4lfte\n                    in besonders hoher Menge mittels PCR nachgewiesen werden. Diese Fallbeschreibung\n                    soll daran erinnern, dass indurative Mastitis unabh\u00e4ngig von den besser\n                    bekannten Manifestationen der Maedi-Visna in Lunge und Gehirn als Folge einer\n                    systemischen MVV-Infektion auftreten kann. MVV sollte daher stets als Ursache\n                    f\u00fcr Mastitis beim Schaf differentialdiagnostisch ber\u00fccksichtigt\n                    werden. F\u00fcr den Nachweis einer MVV-Infektion wird zun\u00e4chst der\n                    Antik\u00f6rperstatus der betroffenen Tiere bzw. der gesamten Herde\n                    ermittelt. Im ver\u00e4nderten Eutergewebe treten charakteristische\n                    histologische Ver\u00e4nderungen auf. MVV-Antigen kann immunhistologisch\n                    dargestellt werden, weiterhin kann MVV-Provirus mittels PCR im\n                    ver\u00e4nderten Eutergewebe und den regionalen Lymphknoten nachgewiesen\n                    werden.<\/jats:p>","DOI":"10.1055\/a-2107-7834","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T18:43:09Z","timestamp":1691779389000},"page":"175-183","source":"Crossref","is-referenced-by-count":1,"title":["Indurative Mastitis in einer Herde Dorperschafe als Folge einer\n                    Infektion mit dem Maedi-Visna-Virus"],"prefix":"10.1055","volume":"51","author":[{"given":"Elisabeth M.","family":"Liebler-Tenorio","sequence":"additional","affiliation":[{"name":"Friedrich-Loeffler Institut \u2013 Bundesforschungsinstitut\n                    f\u00fcr Tiergesundheit (FLI), Institut f\u00fcr Molekulare Pathogenese,\n                    Jena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Moog","sequence":"additional","affiliation":[{"name":"Schaf- und Ziegengesundheitsdienst, Th\u00fcringer Tierseuchenkasse,\n                    Jena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"StefanieA.","family":"Barth","sequence":"additional","affiliation":[{"name":"Friedrich-Loeffler Institut \u2013 Bundesforschungsinstitut\n                    f\u00fcr Tiergesundheit (FLI), Institut f\u00fcr Molekulare Pathogenese,\n                    Jena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Friedrich-Loeffler Institut \u2013 Bundesforschungsinstitut\n                    f\u00fcr Tiergesundheit (FLI), Institut f\u00fcr Virusdiagnostik,\n                    Greifswald \u2013 Insel Riems"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"784","DOI":"10.3390\/ani11030784.","article-title":"Worldwide prevalence of small ruminant lentiviruses in sheep: a systematic\n                    review and meta-analysis","volume":"11","author":"R de Miguel","year":"2021","journal-title":"Animals (Basel)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.vetmic.2015.08.007.","article-title":"Small ruminant lentivirus infections and diseases","volume":"181","author":"E Minguij\u00f3n","year":"2015","journal-title":"Vet Microbiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.cimid.2011.12.003.","article-title":"Small ruminant lentiviruses: immunopathogenesis of visna-maedi and caprine\n                    arthritis and encephalitis virus","volume":"35","author":"B A Blacklaws","year":"2012","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.cvfa.2020.12.003.","article-title":"Update on small ruminant lentiviruses","volume":"37","author":"C Wolf","year":"2021","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1128\/JVI.66.5.2679-2688.1992.","article-title":"Ovine lentivirus is macrophagetropic and does not replicate productively in T\n                    lymphocytes","volume":"66","author":"M D Gorrell","year":"1992","journal-title":"J Virol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/infdis\/90.3.233","article-title":"Maedi, a chronic, progressive infection of sheep\u2019s lungs","volume":"90","author":"B Sigurdsson","year":"1952","journal-title":"J Infect Dis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1097\/00005072-195707000-00010.","article-title":"Grimsson H. 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