{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:28:21Z","timestamp":1762374501740},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Handchir Mikrochir Plast Chir"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund Das Brustimplantat assoziierte Plattenepithelkarzinom\n                    (BIA-SCC) wird als eigenst\u00e4ndige, von der Implantatkapsel ausgehende,\n                    maligne Tumorentit\u00e4t diskutiert. Die FDA und die ASPS\n                    ver\u00f6ffentlichten 2022 eine Mitteilung zum BIA-SCC, wobei bereits in den\n                    1990er Jahren erstmalig ein Fallbericht von BIA-SCC erschien. Das Manuskript\n                    fasst die aktuelle wissenschaftliche Datenlage zu dieser seltenen\n                    Tumorentit\u00e4t zusammen.<\/jats:p><jats:p>\n          Material und Methoden Die Literatur\u00fcbersicht basiert auf einer\n                    systematischen Datenabfrage aus zwei unabh\u00e4ngigen Datenbanken und\n                    schlie\u00dft alle Ver\u00f6ffentlichungen von F\u00e4llen mit\n                    histopathologisch gesichertem BIA-SCC ein. Die Datenextraktion umfasste\n                    Studiendesign, demografische Daten, Informationen zu den Implantaten, sowie\n                    Details zur Diagnostik und Therapie.<\/jats:p><jats:p>\n          Ergebnisse Die Recherche ergab 19 BIA-SCC-F\u00e4lle in 16\n                    Publikationen, mit einem Durchschnittsalter von 57\u00b110 Jahren. Die\n                    Indikation zur Verwendung eines Brustimplantates war in den meisten\n                    F\u00e4llen eine \u00e4sthetische Brustvergr\u00f6\u00dferung\n                    (n=13). Sowohl silikon- (n=11), als auch kochsalzhaltige\n                    (n=7) Implantate mit unterschiedlichen Oberfl\u00e4chen (glatt\n                    n=3, texturiert n=3, polyurethan n=1) wurden eingesetzt.\n                    Symptome wie einseitige Schwellung (n=18), Schmerzen (n=14) und\n                    Erythem (n=5) traten im Durchschnitt 23\u00b19 Jahre nach\n                    Implantation auf. Die Bildgebung zeigte einen Fl\u00fcssigkeitssaum\n                    (n=8) oder eine Tumormasse (n=4) um das Brustimplantat. Die\n                    h\u00e4ufigste chirurgische Therapie war die Explantation mit Kapsulektomie.\n                    In 6 F\u00e4llen wurde eine Metastasierung beschrieben.<\/jats:p><jats:p>\n          Schlussfolgerung Das BIA-SCC ist eine maligne Tumorentit\u00e4t, die\n                    mit Brustimplantaten und der Kapsel um Brustimplantate in Verbindung gebracht\n                    wird. Zum aktuellen Zeitpunkt kann aufgrund der Datenlage aus Studien mit\n                    niedrigem Evidenzgrad V keine endg\u00fcltige Aussage bez\u00fcglich\n                    Korrelation und Kausalit\u00e4t des SCC in Patient*innen mit\n                    Brustimplantaten erfolgen. Es besteht dringender Bedarf nationaler und\n                    internationaler Brustimplantat- und Brustkrebsregister, um valide Daten zu\n                    Inzidenz, Pathogenese, und Klinik seltener Tumorentit\u00e4ten zu\n                    erlangen.<\/jats:p>","DOI":"10.1055\/a-2108-9111","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T22:46:31Z","timestamp":1689893191000},"page":"268-277","source":"Crossref","is-referenced-by-count":4,"title":["Brustimplantat assoziiertes Plattenepithelkarzinom (BIA-SCC)\n                    \u2013 eine systematische Literatur\u00fcbersicht"],"prefix":"10.1055","volume":"55","author":[{"given":"Nicholas","family":"M\u00f6llhoff","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Hand-, Plastische- und \u00c4sthetische\n                    Chirurgie, Klinikum der Universit\u00e4t M\u00fcnchen, LMU\n                    M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Ehrl","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Hand-, Plastische- und \u00c4sthetische\n                    Chirurgie, Klinikum der Universit\u00e4t M\u00fcnchen, LMU\n                    M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Hand-, Plastische- und \u00c4sthetische\n                    Chirurgie, Klinikum der Universit\u00e4t M\u00fcnchen, LMU\n                    M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Frank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Alt","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Hand-, Plastische- und \u00c4sthetische\n             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