{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:35:14Z","timestamp":1773873314106,"version":"3.50.1"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003The effects of prolonged rupture of membranes (ROMs) on perinatal outcomes are still unclear, and it remains controversial for the management of those labors. This study aims to evaluate how the exposure of pregnant women to a prolonged ROM (\u2265 24\u2009hours) affects maternal and neonatal outcomes.<\/jats:p><jats:p>\n            Study Design\u2003This retrospective cohort study included singleton pregnant women at term delivering between January 2019 and March 2020 in a tertiary hospital. All relevant sociodemographic, pregnancy, and perinatal variables (maternal age, prepregnancy body mass index, labor, and delivery outcomes) were collected anonymously. Data were compared between the \u201cROM\u2009&lt;\u200924\u2009hours\u201d and \u201cROM \u2265 24\u2009hours\u201d study groups.<\/jats:p><jats:p>\n            Results\u2003A total of 2,689 dyads were included in the study and divided according to their ROM-delivery time: ROM &lt;24\u2009hours (2,369 women, 88.1%), and ROM \u2265 24\u2009hours (320 women, 11.9%). Maternal baseline characteristics were comparable except for the rate of nulliparous women, which was significantly higher among patients with ROM \u2265 24\u2009hours. No significant differences were found regarding infectious neonatal outcomes. However, mechanical ventilation and continuous positive airway pressure were more common among neonates born after ROM \u2265 24\u2009hours. The greater likelihood of neonatal respiratory distress was also confirmed among infants born to Group-B Streptococcus-negative women with ROM \u2265 24\u2009hours (15 out of 267 neonates, 5.6% vs. 52 out of 1,529 with ROM\u2009&lt;\u200924\u2009hours, 3.4%, p\u2009=\u20090.04).<\/jats:p><jats:p>\n            Conclusion\u2003According to the actual expectant policy, prolonged ROM is associated with an increased risk of respiratory support in noninfected neonates. Further investigations are required to explain such an association.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2109-4109","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T23:15:16Z","timestamp":1686698116000},"page":"e2279-e2285","source":"Crossref","is-referenced-by-count":4,"special_numbering":"S","title":["Exposure to Prolonged Rupture of Membranes at Term Increases the Risk for Ventilatory Support in Uninfected Neonates"],"prefix":"10.1055","volume":"41","author":[{"given":"Anna L.","family":"Tramontano","sequence":"additional","affiliation":[{"name":"Obstetrics Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8531-7124","authenticated-orcid":false,"given":"Daniela","family":"Menichini","sequence":"additional","affiliation":[{"name":"Obstetrics Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Lazzarin","sequence":"additional","affiliation":[{"name":"Obstetrics Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Sponzilli","sequence":"additional","affiliation":[{"name":"Obstetrics Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isotta","family":"Zinani","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Facchinetti","sequence":"additional","affiliation":[{"name":"Obstetrics Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3534-7499","authenticated-orcid":false,"given":"Alberto","family":"Berardi","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"ref1","first-page":"347","article-title":"Does prolonged preterm premature rupture of the membranes predispose to abruptio placentae?","volume":"74","author":"R Gonen","year":"1989","journal-title":"Obstet Gynecol"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0146-0005(96)80004-8","article-title":"Premature rupture of the membranes: neonatal consequences","volume":"20","author":"G B Merenstein","year":"1996","journal-title":"Semin Perinatol"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejogrb.2003.07.007","article-title":"Prelabor rupture of the membranes at term: when to induce labor?","volume":"115","author":"Y Ezra","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"16","key":"ref4","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJM199604183341601","article-title":"Induction of labor compared with expectant management for prelabor rupture of the membranes at term","volume":"334","author":"M E Hannah","year":"1996","journal-title":"N Engl J Med"},{"issue":"16","key":"ref5","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJM199604183341601","article-title":"Induction of labor compared with expectant management for prelabor rupture of the membranes at term","volume":"334","author":"M E Hannah","year":"1996","journal-title":"N Engl J Med"},{"issue":"01","key":"ref6","first-page":"CD005302","article-title":"Planned early birth versus expectant management (waiting) for prelabour rupture of membranes at term (37 weeks or more)","volume":"1","author":"P Middleton","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"01","key":"ref7","first-page":"1","article-title":"The American College of Obstetricians and Gynecologists. Prevention of Group B Streptococcal Early-Onset Disease in Newborns: ACOG Committee Opinion Summary, Number 782","volume":"134","year":"2019","journal-title":"Obstet Gynecol"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1258\/jms.2011.011023","article-title":"Universal antenatal screening for group B streptococcus in Emilia-Romagna","volume":"18","author":"A Berardi","year":"2011","journal-title":"J Med Screen"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"544460","DOI":"10.3389\/fped.2020.544460","article-title":"The dark side of antibiotics: adverse effects on the infant immune defense against infection","volume":"8","author":"S Shekhar","year":"2020","journal-title":"Front Pediatr"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/ni.2847","article-title":"Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease","volume":"15","author":"S Zeissig","year":"2014","journal-title":"Nat Immunol"},{"issue":"06","key":"ref11","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1080\/14767058.2018.1506760","article-title":"Changes of intestinal microbiota in early life","volume":"33","author":"M Ficara","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.pcl.2014.11.008","article-title":"Neonatal respiratory distress: a practical approach to its diagnosis and management","volume":"62","author":"A K Pramanik","year":"2015","journal-title":"Pediatr Clin North Am"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"e20182896","DOI":"10.1542\/peds.2018-2896","article-title":"Management of neonates born at \u226434 6\/7 weeks' gestation with suspected or proven early-onset bacterial sepsis","volume":"142","author":"K M Puopolo","year":"2018","journal-title":"Pediatrics"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1097\/AOG.0000000000002236","article-title":"Committee Opinion No. 712: intrapartum management of intraamniotic infection","volume":"130","author":"Committee Opinion No","year":"2017","journal-title":"Obstet Gynecol"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1097\/AOG.0b013e318219229b","article-title":"ACOG Committee Opinion No. 485: prevention of early-onset group B streptococcal disease in newborns","volume":"117","author":"Committee Opinion No","year":"2011","journal-title":"Obstet Gynecol"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/MOP.0000000000000864","article-title":"Serial clinical observation for management of newborns at risk of early-onset sepsis","volume":"32","author":"A Berardi","year":"2020","journal-title":"Curr Opin Pediatr"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.clp.2021.05.003","article-title":"The term newborn: early-onset sepsis","volume":"48","author":"K M Puopolo","year":"2021","journal-title":"Clin Perinatol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"882416","DOI":"10.3389\/fped.2022.882416","article-title":"Should we give antibiotics to neonates with mild non-progressive symptoms? A comparison of serial clinical observation and the neonatal sepsis risk calculator","volume":"10","author":"A Berardi","year":"2022","journal-title":"Front Pediatr"},{"issue":"06","key":"ref20","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1542\/peds.103.6.e77","article-title":"Risk factors for early-onset group B streptococcal sepsis: estimation of odds ratios by critical literature review","volume":"103","author":"W E Benitz","year":"1999","journal-title":"Pediatrics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"100255","DOI":"10.1016\/j.eclinm.2019.100255","article-title":"Finding a role for the neonatal early-onset sepsis risk calculator","volume":"19","author":"W E Benitz","year":"2020","journal-title":"EClinicalMedicine"},{"issue":"05","key":"ref22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0146-0005(96)80003-6","article-title":"Clinical course of premature rupture of the membranes","volume":"20","author":"J M Alexander","year":"1996","journal-title":"Semin Perinatol"},{"issue":"04","key":"ref23","doi-asserted-by":"crossref","first-page":"292.e1","DOI":"10.1016\/j.ajog.2012.07.022","article-title":"Neonatal respiratory morbidity in the early term delivery","volume":"207","author":"K Ghartey","year":"2012","journal-title":"Am J Obstet Gynecol"},{"issue":"01","key":"ref24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/AOG.0b013e3181e10c5c","article-title":"Labor induction and the risk of a cesarean delivery among nulliparous women at term","volume":"116","author":"D B Ehrenthal","year":"2010","journal-title":"Obstet Gynecol"},{"issue":"02","key":"ref25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/aogs.14068","article-title":"Induction of labor and cesarean section","volume":"100","author":"A Bhide","year":"2021","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"03","key":"ref26","doi-asserted-by":"crossref","first-page":"326.e1","DOI":"10.1016\/j.ajog.2022.09.018","article-title":"Optimal timing of labor induction after prelabor rupture of membranes at term: a secondary analysis of the TERMPROM study","volume":"228","author":"N Melamed","year":"2023","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2109-4109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:36:44Z","timestamp":1730813804000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2109-4109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,13]]},"references-count":25,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2109-4109","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6,13]]},"published":{"date-parts":[[2023,6,13]]}}}