{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:21:44Z","timestamp":1782487304814,"version":"3.54.5"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thyroid cancer is a tumor that occurs in the head and neck, which originates from\n                    the thyroid follicular epithelial cells. The current research is discussed and\n                    elaborated from the perspective of molecular prognostic biomarkers to gain a\n                    deeper understanding of the molecular mechanism of thyroid cancer and to provide\n                    more effective treatment and prognostic methods for patients. Thyroid cancer\n                    patients were explored from histological, cellular and clinical levels.\n                    Real-time quantitative polymerase chain reaction (RT-qPCR) was used to detect\n                    the expression of LINC00847 and miR-146b-5p in the tissues and cells of the\n                    subjects. Cell growth and thyroid cancer progression were determined by the cell\n                    counting kit-8 (CCK-8) and transwell assays. The LINC00847 sponge miR-146b-5p\n                    was assessed by bioinformatics tools and luciferase reporter assay, and the\n                    Kaplan\u2013Meier method and multivariate Cox regression analysis suggested\n                    the prognostic value of high expression of LINC00847. In thyroid cancer tissues\n                    and cells, the expression of LINC00847 was decreased. Overexpression of\n                    LINC00847 remarkably inhibited the proliferation level, migration ability and\n                    invasion ability of thyroid cancer cells. Besides, miR-146b-5p was upregulated\n                    in thyroid cancer tissues and cells. It was confirmed that LINC00847 targeting\n                    miR-146b-5p had a regulatory effect on the progression of thyroid cancer, and\n                    LINC00847 was negatively correlated with miR-146b-5p. LINC00847 may be\n                    considered a meaningful prognostic marker to influence tumor growth through\n                    sponge miR-146b-5p, which provides a new basis for the prognosis and treatment\n                    of thyroid cancer.<\/jats:p>","DOI":"10.1055\/a-2111-3821","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T14:48:25Z","timestamp":1690382905000},"page":"794-800","source":"Crossref","is-referenced-by-count":1,"title":["Aberrantly Expressed lncRNA LINC00847 May Serve as a Promising\n                    Prognostic Factor for Thyroid Cancer"],"prefix":"10.1055","volume":"55","author":[{"given":"Guoli","family":"Hei","sequence":"first","affiliation":[{"name":"Radiation Oncology, The Affiliated Hospital of Qingdao University,\n                    Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yu","sequence":"first","affiliation":[{"name":"Outpatient, Huai\u2019an No 4 People\u2019s Hospital,\n                    Huai\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[{"name":"General Surgery (Thyroid Gland\/Blood Vessel), The First\n                    People\u2019s Hospital of Neijiang, Neijiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"General Surgery (Thyroid Gland\/Blood Vessel), The First\n                    People\u2019s Hospital of Neijiang, Neijiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1111\/1759-7714.14099","article-title":"Global burden of thyroid cancer and its attributable risk factors in 204\n                    countries and territories from 1990 to 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human bladder cancer cells by\n                    directly targeting oncogene KLF5","volume":"25","author":"Z Jiang","year":"2017","journal-title":"Oncol Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"600927","DOI":"10.3389\/fonc.2020.600927","article-title":"Long non-coding RNA MAPK8IP1P2 inhibits lymphatic metastasis of thyroid cancer\n                    by activating hippo signaling via sponging miR-146b-3p","volume":"10","author":"X Liu","year":"2020","journal-title":"Front Oncol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"811809","DOI":"10.3389\/fvets.2021.811809","article-title":"Comparison of intra-CL injection and peripheral application of prostaglandin\n                    F(2\u03b1) analog on luteal blood flow and secretory function of the bovine\n                    corpus luteum","volume":"8","author":"A W Jonczyk","year":"2021","journal-title":"Front Vet Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/S0140-6736(16)30172-6","article-title":"Thyroid cancer","volume":"388","author":"M E Cabanillas","year":"2016","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4274\/mirt.35220","article-title":"Recurrence incidence in differentiated thyroid cancers and the importance of\n                    diagnostic iodine-131 scintigraphy in clinical follow-up","volume":"25","author":"F Hatipo\u011flu","year":"2016","journal-title":"Mol Imaging Radionucl Ther"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s13046-018-0950-9","article-title":"LncRNA XIST\/miR-34a axis modulates the cell proliferation and tumor\n                    growth of thyroid cancer through MET-PI3K-AKT signaling","volume":"37","author":"H Liu","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"6664","DOI":"10.1038\/s41388-020-01460-3","article-title":"LncRNA SLC26A4-AS1 suppresses the MRN complex-mediated DNA repair signaling and\n                    thyroid cancer metastasis by destabilizing DDX5","volume":"39","author":"J Yuan","year":"2020","journal-title":"Oncogene"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1080\/15384047.2018.1449610","article-title":"LncRNA PTCSC3 affects drug resistance of anaplastic thyroid cancer through\n                    STAT3\/INO80 pathway","volume":"19","author":"X M Wang","year":"2018","journal-title":"Cancer Biol Ther"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s12885-022-09360-3","article-title":"LncRNA CALML3-AS1 suppresses papillary thyroid cancer progression via sponging\n                    miR-20a-5p\/RBM38 axis","volume":"22","author":"X Zhang","year":"2022","journal-title":"BMC Cancer"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s12020-017-1520-1","article-title":"LncRNA GAS8-AS1 inhibits cell proliferation through ATG5-mediated autophagy in\n                    papillary thyroid cancer","volume":"59","author":"Y Qin","year":"2018","journal-title":"Endocrine"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.2147\/CMAR.S312621","article-title":"TNRC6C-AS1 Promotes thyroid cancer progression by upregulating LPAR5 via\n                    miR-513c-5p","volume":"13","author":"C Tong","year":"2021","journal-title":"Cancer Manag Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"12094","DOI":"10.1111\/jcmm.15846","article-title":"LINC00470 promotes tumour proliferation and invasion, and attenuates\n                    chemosensitivity through the LINC00470\/miR-134\/Myc\/ABCC1\n                    axis in glioma","volume":"24","author":"C Wu","year":"2020","journal-title":"J Cell Mol Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s10038-019-0583-7","article-title":"Previously undescribed thyroid-specific miRNA sequences in papillary thyroid\n                    carcinoma","volume":"64","author":"M C Barros-Filho","year":"2019","journal-title":"J Hum Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.beem.2016.10.001","article-title":"MicroRNAs in the thyroid","volume":"30","author":"M Boufraqech","year":"2016","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref31","first-page":"433","article-title":"MiR-146b-5p regulates the expression of long noncoding RNA MALAT1 and its effect\n                    on the invasion and proliferation of papillary thyroid cancer","volume":"36","author":"Y Peng","year":"2021","journal-title":"Cancer Biother Radiopharm"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1002\/jcp.30245","article-title":"Colorectal cancer prompted adipose tissue browning and cancer cachexia through\n                    transferring exosomal miR-146b-5p","volume":"236","author":"W Di","year":"2021","journal-title":"J Cell Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3892\/etm.2021.9829","article-title":"Long non-coding RNA SNHG7 facilitates pancreatic cancer progression by\n                    regulating the miR-146b-5p\/Robo1 axis","volume":"21","author":"Y Jian","year":"2021","journal-title":"Exp Ther Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1186\/s12935-021-02114-4","article-title":"Lnc-STYK1-2 regulates bladder cancer cell proliferation, migration, and invasion\n                    by targeting miR-146b-5p expression and AKT\/STAT3\/NF-kB\n                    signaling","volume":"21","author":"R Dai","year":"2021","journal-title":"Cancer Cell Int"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.7150\/jca.16961","article-title":"MiR-146b-5p functions as a suppressor miRNA and prognosis predictor in non-small\n                    cell lung cancer","volume":"8","author":"Y Li","year":"2017","journal-title":"J Cancer"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1038\/onc.2011.381","article-title":"MicroRNA miR-146b-5p regulates signal transduction of TGF-\u03b2 by\n                    repressing SMAD4 in thyroid cancer","volume":"31","author":"M V Geraldo","year":"2012","journal-title":"Oncogene"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2111-3821.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:41:32Z","timestamp":1730806892000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2111-3821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,6]]},"references-count":36,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,10,30]]},"published-print":{"date-parts":[[2023,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2111-3821","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,6]]}}}