{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:52:40Z","timestamp":1791229960790,"version":"4.1.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"11","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Dutch Digestive Foundation","award":["SK 18\u201312"],"award-info":[{"award-number":["SK 18\u201312"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>\n            Background\u2002Patients with head and neck squamous cell carcinoma (HNSCC) can develop second primary tumors (SPTs) in the esophagus. Endoscopic screening could lead to detection of SPTs at early stages and improve survival.<\/jats:p><jats:p>\n            Methods\u2002We performed a prospective endoscopic screening study in patients with curably treated HNSCC diagnosed between January 2017\u2013July 2021 in a Western country. Screening was performed synchronously (&lt;\u200a6 months) or metachronously (\u2265\u200a6 months) after HNSCC diagnosis. Routine imaging for HNSCC consisted of flexible transnasal endoscopy with positron emission tomography\/computed tomography or magnetic resonance imaging, depending on primary HNSCC location. The primary outcome was prevalence of SPTs, defined as presence of esophageal high grade dysplasia or squamous cell carcinoma.<\/jats:p><jats:p>\n            Results\u2002202 patients (mean age 65 years, 80.7\u200a% male) underwent 250 screening endoscopies. HNSCC was located in the oropharynx (31.9\u200a%), hypopharynx (26.9\u200a%), larynx (22.2\u200a%), and oral cavity (18.5\u200a%). Endoscopic screening was performed within 6 months (34.0\u200a%), 6 months to 1 year (8.0\u200a%), 1\u20132 years (33.6\u200a%), and 2\u20135 years (24.4\u200a%) after HNSCC diagnosis. We detected 11 SPTs in 10 patients (5.0\u200a%, 95\u200a%CI 2.4\u200a%\u20138.9\u200a%) during synchronous (6\/85) and metachronous (5\/165) screening. Most patients had early stage SPTs (90\u200a%) and were treated with curative intent with endoscopic resection (80\u200a%). No SPTs in screened patients were detected with routine imaging for HNSCC before endoscopic screening.<\/jats:p><jats:p>\n            Conclusion\u2002In 5\u200a% of patients with HNSCC, an SPT was detected with endoscopic screening. Endoscopic screening should be considered in selected HNSCC patients to detect early stage SPTs, based on highest SPT risk and life expectancy according to HNSCC and comorbidities.<\/jats:p>","DOI":"10.1055\/a-2111-5935","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T23:14:51Z","timestamp":1686957291000},"page":"981-990","source":"Crossref","is-referenced-by-count":24,"title":["Endoscopic screening of the upper gastrointestinal tract for second primary tumors in patients with head and neck cancer in a Western country"],"prefix":"10.1055","volume":"55","clinical-trial-number":[{"clinical-trial-number":"nl7299","registry":"10.18810\/dutch-trial-register"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1341-0044","authenticated-orcid":false,"given":"Laurelle","family":"van Tilburg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9793-0957","authenticated-orcid":false,"given":"Steffi E. M.","family":"van de Ven","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter Jan F.","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilmar","family":"de Graaf","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-9757","authenticated-orcid":false,"given":"Manon C. W.","family":"Spaander","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Nikkessen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Hardillo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniel","family":"Sewnaik","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominiek A.","family":"Monserez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hetty","family":"Mast","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn","family":"Keereweer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco J.","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Baatenburg de Jong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-2126","authenticated-orcid":false,"given":"Arjun D.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the 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