{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:50:11Z","timestamp":1780516211325,"version":"3.54.1"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"12","funder":[{"DOI":"10.13039\/501100007288","name":"Mahasarakham University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007288","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Clausena excavata is a medicinal plant widely distributed in Southeast Asia. It is used for a variety of indications, including to treat malaria. In our present study, a\n          phytochemical study of the methanol extract from the stem bark of C. excavata led to the isolation of five pyranocoumarins, nordentatin (1), dentatin (2), kinocoumarin\n          (3), clausarin (4), and clausenidin (5), and a coumarin, 8-hydroxy-3\u2033,4\u2033-dihydrocapnolactone-2\u2032,3\u2032-diol (6). The isolation of compound 6 from C.\n          excavata and the antiplasmodial activities against a multidrug-resistant K1 strain of Plasmodium falciparum of 1, 3, and 5 were reported for the first time.\n          Compounds 3 and 4 exhibited potent antiplasmodial activities with EC50 values of 1.10 and 0.58\u2009\u00b5M, respectively, while 1 and 5 had EC50\n          values of 5.62 and 7.15\u2009\u00b5M, respectively. A prenyl group attached to the C-3 or C-12 position on the pyranocoumarin ring probably plays an important role on the activity. A hydroxyl group at\n          the C-10 position is also likely to enhance the activity.<\/jats:p>","DOI":"10.1055\/a-2112-6631","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T22:51:22Z","timestamp":1688683882000},"page":"1165-1169","source":"Crossref","is-referenced-by-count":2,"title":["Bioassay-Guided Isolation and Identification of Antiplasmodial Compounds from the Stem Bark of Clausena excavata"],"prefix":"10.1055","volume":"89","author":[{"given":"Prapairat","family":"Seephonkai","sequence":"additional","affiliation":[{"name":"Multidisciplinary Research Unit of Pure and Applied Chemistry, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science,\n          Mahasarakham University, Khamriang, Kantarawichai, Maha Sarakham, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chatthai","family":"Kaewtong","sequence":"additional","affiliation":[{"name":"Multidisciplinary Research Unit of Pure and Applied Chemistry, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science,\n          Mahasarakham University, Khamriang, Kantarawichai, Maha Sarakham, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phurpa","family":"Wangchuk","sequence":"additional","affiliation":[{"name":"Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns Campus, Smithfield, Queenland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedchin","family":"Jearawuttanakul","sequence":"additional","affiliation":[{"name":"Excellent Center for Drug Discovery, Faculty of Science, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phongthon","family":"Kanjanasirirat","sequence":"additional","affiliation":[{"name":"Excellent Center for Drug Discovery, Faculty of Science, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suparerk","family":"Borwornpinyo","sequence":"additional","affiliation":[{"name":"Excellent Center for Drug Discovery, Faculty of Science, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tachin","family":"Khulmanee","sequence":"additional","affiliation":[{"name":"Drug Research Unit for Malaria, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapatbhorn","family":"Patrapuvich","sequence":"additional","affiliation":[{"name":"Drug Research Unit for Malaria, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"ref3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0031-9422(96)00532-8","article-title":"Two coumarins from the root bark of Clausena excavata","volume":"44","author":"S C Huang","year":"1997","journal-title":"Phytochemistry"},{"key":"ref4","volume-title":"Medicinal Plants of East and Southeast Asia: Attributed Properties and Used","author":"L M Perry","year":"1980"},{"key":"ref5","first-page":"36","volume-title":"\u201cKhoyo Taiwan Minkun Yakyo Shokubutsu Shi\u201d, Khobunkan","author":"S Sasaki","year":"1924"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1021\/np50024a013","article-title":"Biological and phytochemical investigation of Clausena excavata","volume":"45","author":"T S Wu","year":"1982","journal-title":"J Nat 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