{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:16:58Z","timestamp":1788959818120,"version":"build-2803163510"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"11","funder":[{"DOI":"10.13039\/501100010804","name":"Faculty of Medicine, Prince of Songkla University","doi-asserted-by":"crossref","award":["REC. 60-455-01-1"],"award-info":[{"award-number":["REC. 60-455-01-1"]}],"id":[{"id":"10.13039\/501100010804","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>\n            Objective\u2003Nasal high-frequency oscillatory ventilation (nHFOV) and synchronized nasal intermittent positive pressure ventilation (sNIPPV) yield a lower partial pressure of carbon dioxide (pCO2) after extubation than nasal continuous positive airway pressure. Our aim was to clarify which of the two was superior.<\/jats:p><jats:p>\n            Study Design\u2003We performed a crossover randomized study to evaluate pCO2 level among 102 participants from July 2020 to June 2022. Intubated preterm and term neonates with arterial lines were randomly allocated to nHFOV\u2013sNIPPV or sNIPPV\u2013nHFOV sequences; their pCO2 levels were measured after 2\u2009hours in each mode. Subgroup analyses were performed for preterm (gestational age &lt;37 weeks) and very preterm (gestational age &lt;32 weeks) neonates.<\/jats:p><jats:p>\n            Results\u2003The mean gestational age (nHFOV\u2013sNIPPV, 32.8 vs. sNIPPV\u2013nHFOV, 33.5 weeks) and median birth weight (1,850 vs. 1,930\u2009g) did not differ between the sequences. The mean\u2009\u00b1\u2009standard deviation pCO2 level after nHFOV (38.7\u2009\u00b1\u20098.8\u2009mm Hg) was significantly higher than that after sNIPPV (36.8\u2009\u00b1\u200910.2\u2009mm Hg; mean difference: 1.9\u2009mm Hg; 95% confidence interval: 0.3\u20133.4\u2009mm Hg; treatment effect [p\u2009=\u20090.007] but no sequence [p\u2009=\u20090.92], period [p\u2009=\u20090.53], or carryover [p\u2009=\u20090.94] effects). However, the difference in pCO2 level between the sequences was not statistically significant in the subgroup analyses of preterm and very preterm neonates.<\/jats:p><jats:p>\n            Conclusion\u2003After neonatal extubation, the sNIPPV mode was associated with a lower pCO2 level than the nHFOV mode with no significant difference in preterm and very preterm neonates.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2113-3284","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T22:56:02Z","timestamp":1687301762000},"page":"1495-1503","source":"Crossref","is-referenced-by-count":7,"title":["Carbon Dioxide Level between Nasal High-Frequency Oscillatory Ventilation and Synchronized Nasal Intermittent Positive Pressure Ventilation after Extubation in Neonates: A Cross-over Randomized Controlled Trial"],"prefix":"10.1055","volume":"41","clinical-trial-number":[{"clinical-trial-number":"nct04323397","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Kulthida","family":"Baingam","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manapat","family":"Phatigomet","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2363-6362","authenticated-orcid":false,"given":"Anucha","family":"Thatrimontrichai","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6332-3216","authenticated-orcid":false,"given":"Gunlawadee","family":"Maneenil","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supaporn","family":"Dissaneevate","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waricha","family":"Janjindamai","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, 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Chen","year":"2019","journal-title":"Chest"}],"container-title":["American Journal of 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