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Compounds 1\u200a\u2013\u200a13, mainly representing\n          ellagitannins, were isolated using different chromatographic methods, and their structures were elucidated by HR-MS and 1H\/13C-NMR. AWE exerted concentration-dependent\n          lethal effects (LC50 of 2.6\u2009mg\/mL) against C. elegans and inhibited larval migration of all animal parasites tested (T. suis L1 IC50 24.3\u2009\u00b5g\/mL,\n          A.\u00a0suum L3 IC50 35.7\u2009\u00b5g\/mL, A.\u00a0caninum L3 IC50 112.8\u2009\u00b5g\/mL, T. canis L3 IC50 1513.2\u2009\u00b5g\/mL). The anthelmintic activity of AWE was mainly\n          related to the polar, tannin-containing fractions. Geraniin 1, the major ellagitannin in the extract, showed the strongest anthelmintic activity in general (IC50 between\n          0.6 and 804\u2009\u00b5M, depending on parasite species) and was the only compound active against A.\u00a0caninum (IC50 of 35.0\u2009\u00b5M). Furosin 9 was least active despite structural\n          similarities to 1. Among the parasites tested, Trichuris suis L1 larvae turned out to be most sensitive with IC50 of 0.6, 6.4, 4.0, 4.8, and 2.6\u2009\u00b5M for geraniin\n          1, repandusinic acid A 3, punicafolin 8, furosin 9, and phyllanthusiin A 10, respectively.<\/jats:p>","DOI":"10.1055\/a-2117-9426","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T22:38:16Z","timestamp":1689633496000},"page":"1215-1228","source":"Crossref","is-referenced-by-count":6,"title":["Anthelmintic Activities of Extract and Ellagitannins from Phyllanthus urinaria against Caenorhabditis elegans and Zoonotic or Animal Parasitic\n          Nematodes"],"prefix":"10.1055","volume":"89","author":[{"given":"Jonathan","family":"Jato","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster, Institute of Pharmaceutical Biology and Phytochemistry, M\u00fcnster, Germany"},{"name":"Kwame Nkrumah University of Science and Technology, Faculty of Pharmacy and Pharmaceutical Sciences, Kumasi, Ghana"},{"name":"University of Health and Allied Sciences, School of Pharmacy, Ho, Ghana"},{"name":"University of M\u00fcnster, Institute of Integrative Cell Biology and Physiology, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Waindok","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine Hannover, Institute for Parasitology, Centre for Infection Medicine, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois Ngnodandi Belga Fran\u00e7ois","family":"Ngnodandi","sequence":"additional","affiliation":[{"name":"University of Ngaoundere, Faculty of Sciences, Department of Biological Sciences, Ngaound\u00e9r\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Orman","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster, Institute of Pharmaceutical Biology and Phytochemistry, M\u00fcnster, Germany"},{"name":"University of Health and Allied Sciences, School of Pharmacy, Ho, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Agyare","sequence":"additional","affiliation":[{"name":"Kwame Nkrumah University of Science and Technology, Faculty of Pharmacy and Pharmaceutical Sciences, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emelia Oppong","family":"Bekoe","sequence":"additional","affiliation":[{"name":"University of Ghana, College of Health Science, School of Pharmacy, Accra, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Strube","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine Hannover, Institute for Parasitology, Centre for Infection Medicine, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-8384","authenticated-orcid":false,"given":"Andreas","family":"Hensel","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster, Institute of Pharmaceutical Biology and Phytochemistry, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Liebau","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster, Institute of Integrative Cell Biology and Physiology, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Spiegler","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster, Institute of Pharmaceutical Biology and Phytochemistry, M\u00fcnster, 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