{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:28:52Z","timestamp":1767864532897,"version":"3.49.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to determine neurodevelopmental outcomes of preterm infants born at &lt;29 weeks' gestational age (GA) with bronchopulmonary dysplasia and pulmonary hypertension (BPD\u2013PH) at 18 to 24 months' corrected age (CA).<\/jats:p><jats:p>\n            Study Design\u2003In this retrospective cohort study, preterm infants born at &lt;29 weeks' GA between January 2016 and December 2019, admitted to level 3 neonatal intensive care units, who developed BPD and were evaluated at 18 to 24 months' CA in the neonatal follow-up clinics were included. We compared demographic characteristics and neurodevelopmental outcomes between the two groups: Group I: BPD with PH and Group II: BPD with no PH, using univariate and multivariate regression models. The primary outcome was a composite of death or neurodevelopmental impairment (NDI). NDI was defined as any Bayley-III score\u2009&lt;\u200985 on one or more of the cognitive, motor, or language composite scores.<\/jats:p><jats:p>\n            Results\u2003Of 366 eligible infants, 116 (Group I [BPD\u2013PH] =7, Group II [BPD with no PH]\u2009=\u2009109) were lost to follow-up. Of the remaining 250 infants, 51 in Group I and 199 in Group II were followed at 18 to 24 months' CA. Group I and Group II had median (interquartile range [IQR]) birthweights of 705 (325) and 815\u2009g (317; p\u2009=\u20090.003) and median GAs (IQR) were 25 (2) and 26 weeks (2; p\u2009=\u20090.015) respectively. Infants in the BPD\u2013PH group (Group I) were more likely to have mortality or NDI (adjusted odds ratio: 3.82; bootstrap 95% confidence interval; 1.44\u201340.87).<\/jats:p><jats:p>\n            Conclusion\u2003BPD\u2013PH in infants born at &lt;29 weeks' GA is associated with increased odds of the composite outcome of death or NDI at 18 to 24 months' CA.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2121-8878","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T23:10:19Z","timestamp":1688425819000},"page":"e2505-e2513","source":"Crossref","is-referenced-by-count":3,"special_numbering":"S","title":["Neurodevelopmental Outcomes of Preterm Infants Born &lt;29 Weeks with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Multicenter Study"],"prefix":"10.1055","volume":"41","author":[{"given":"Soumya R.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Neonatal Follow-up Clinic, Alberta Children's Hospital, Alberta Health Services, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashanth","family":"Murthy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Neonatal Follow-up Clinic, Alberta Children's Hospital, Alberta Health Services, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chacko J.","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Neonatal Follow-up Clinic, Alberta Children's Hospital, Alberta Health Services, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amuchou","family":"Soraisham","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Neonatal Follow-up Clinic, Alberta Children's Hospital, Alberta Health Services, Calgary, Alberta, Canada"},{"name":"Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selphee","family":"Tang","sequence":"additional","affiliation":[{"name":"Neonatal Follow-up Clinic, Alberta Children's Hospital, Alberta Health Services, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliyah","family":"Dosani","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery, Faculty of Health, Community and Education, Mount Royal University, Calgary, Alberta, Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay","family":"Lodha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Neonatal Follow-up Clinic, Alberta Children's Hospital, Alberta Health Services, Calgary, Alberta, Canada"},{"name":"Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,7,29]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1055\/s-0036-1586107","article-title":"Mechanisms of lung injury and bronchopulmonary dysplasia","volume":"33","author":"A H Jobe","year":"2016","journal-title":"Am J Perinatol"},{"key":"ref2","volume-title":"The Canadian Neonatal Network: Annual Report 2020","author":"M SP Beltempo","year":"2020"},{"issue":"07","key":"ref3","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1055\/s-0032-1329690","article-title":"Higher altitude and risk of bronchopulmonary dysplasia among preterm infants","volume":"30","author":"S K Lee","year":"2013","journal-title":"Am J Perinatol"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1053\/j.semperi.2006.05.010","article-title":"Neurodevelopmental outcome of bronchopulmonary dysplasia","volume":"30","author":"P J Anderson","year":"2006","journal-title":"Semin Perinatol"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/jcm6010004","article-title":"Bronchopulmonary dysplasia: chronic lung disease of infancy and long-term pulmonary outcomes","volume":"6","author":"L M Davidson","year":"2017","journal-title":"J Clin Med"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/bdra.23235","article-title":"Epidemiology of bronchopulmonary dysplasia","volume":"100","author":"E A Jensen","year":"2014","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"e90843","DOI":"10.1371\/journal.pone.0090843","article-title":"Need for supplemental oxygen at discharge in infants with bronchopulmonary dysplasia is not associated with worse neurodevelopmental outcomes at 3 years corrected age","volume":"9","author":"A Lodha","year":"2014","journal-title":"PLoS One"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/jp.2016.250","article-title":"Bronchopulmonary dysplasia and pulmonary hypertension: a meta-analysis","volume":"37","author":"G Al-Ghanem","year":"2017","journal-title":"J Perinatol"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/bdra.23241","article-title":"Pulmonary hypertension in bronchopulmonary dysplasia","volume":"100","author":"N Ambalavanan","year":"2014","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1067\/mpd.2002.122730","article-title":"Neurodevelopmental and medical outcomes of persistent pulmonary hypertension in term newborns treated with nitric oxide","volume":"140","author":"P H Lipkin","year":"2002","journal-title":"J Pediatr"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1542\/peds.90.3.392","article-title":"Hearing and neurodevelopmental outcome in survivors of persistent pulmonary hypertension of the newborn","volume":"90","author":"M J Marron","year":"1992","journal-title":"Pediatrics"},{"issue":"04","key":"ref12","first-page":"58","article-title":"Neurodevelopmental outcome of newborns with persistent pulmonary hypertension","volume":"18","author":"J Rohana","year":"2011","journal-title":"Malays J Med Sci"},{"issue":"S 02","key":"ref13","doi-asserted-by":"crossref","first-page":"ii49","DOI":"10.1136\/heartjnl-2015-308591","article-title":"Pulmonary hypertension associated with acute or chronic lung diseases in the preterm and term neonate and infant. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK","volume":"102","author":"A Hilgendorff","year":"2016","journal-title":"Heart"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12887-019-1400-3","article-title":"Developmental outcomes of preterm infants with bronchopulmonary dysplasia-associated pulmonary hypertension at 18-24\u2009months of corrected age","volume":"19","author":"E K Choi","year":"2019","journal-title":"BMC Pediatr"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/pch\/pxz024","article-title":"Incidence, risk factors, and outcomes of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia","volume":"25","author":"K MacKenzie","year":"2020","journal-title":"Paediatr Child Health"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/jp.2016.108","article-title":"Impact of pulmonary hypertension on neurodevelopmental outcome in preterm infants with bronchopulmonary dysplasia: a cohort study","volume":"36","author":"H Nakanishi","year":"2016","journal-title":"J Perinatol"},{"issue":"09","key":"ref17","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/j.1651-2227.2005.tb02095.x","article-title":"Ages and Stages Questionnaire used to measure cognitive deficit in children born extremely preterm","volume":"94","author":"A Klamer","year":"2005","journal-title":"Acta Paediatr"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"e1468","DOI":"10.1542\/peds.2012-3313","article-title":"Validity of the ages and stages questionnaires in term and preterm infants","volume":"131","author":"L Schonhaut","year":"2013","journal-title":"Pediatrics"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1542\/peds.82.4.527","article-title":"Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period","volume":"82","author":"A T Shennan","year":"1988","journal-title":"Pediatrics"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1469-8749.1997.tb07414.x","article-title":"Development and reliability of a system to classify gross motor function in children with cerebral palsy","volume":"39","author":"R Palisano","year":"1997","journal-title":"Dev Med Child Neurol"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging","volume":"187","author":"M J Bell","year":"1978","journal-title":"Ann Surg"},{"issue":"04","key":"ref22","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm","volume":"92","author":"L A Papile","year":"1978","journal-title":"J Pediatr"},{"issue":"07","key":"ref23","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3346\/jkms.2015.30.7.911","article-title":"Disease-specific growth charts of Marfan syndrome patients in Korea","volume":"30","author":"Y Kwun","year":"2015","journal-title":"J Korean Med Sci"},{"key":"ref24","first-page":"197","article-title":"Parental assessment on neurodevelopmental outcomes in children born late preterm at 2, 3, 5 and 8 years old","volume":"106","author":"D SCJ Raimundo","year":"2021","journal-title":"Arch Dis Child"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2121-8878.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:39:52Z","timestamp":1730813992000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2121-8878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,3]]},"references-count":24,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2121-8878","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,7,3]]},"published":{"date-parts":[[2023,7,3]]}}}