{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:28:33Z","timestamp":1774956513971,"version":"3.50.1"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This article tests the protective effect of a commercially available mixture of hyaluronic acid, chondroitin sulfate, and poloxamer 407 on the damage caused by the exposure of esophageal mucosa to button batteries in an animal model.<\/jats:p><jats:p>\n          Methods\u2003Experimental study. Sixty porcine esophageal samples were distributed in three groups: control (CG), exposure (EG), and exposure-protection (EPG). In EG and EPG, one CR2032 button battery per sample was inserted, both were subdivided into 2-, 4-, 6-, and 24-hour exposure subgroups, with subsequent battery removal. EPG samples were irrigated with the solution 1\u2009hour after battery exposure. Esophageal pH and final voltage of the battery were measured.<\/jats:p><jats:p>\n          Results\u2003pH in CG remained stable. No significant differences in pH at 1\u2009hour were found between EG and EPG. In EPG, the pH of the mucosa exposed to the anode was lower than in GE at 2\u2009hours (12.44 vs. 11.89, p\u2009=\u20090.203) and 4\u2009hours (13.78 vs. 11.77, p\u2009&lt;\u20090.0001). In the cathode pH was significantly higher in EG at 2\u2009hours (2.5 vs. 4.11, p\u2009&lt;\u20090.0001), 4\u2009hours (2.33 vs. 4.78, p\u2009&lt;\u20090.0001), and 6\u2009hours (2.17 vs. 2.91, p\u2009&lt;\u20090.0001). Significant voltage reduction at 1\u2009hour was found in EG compared to EPG (0.48 vs. 1.08\u2009V, p\u2009=\u20090.004).<\/jats:p><jats:p>\n          Conclusion\u2003Exposure to hyaluronic acid solution buffers the acidification on the side exposed to the cathode and basification on the anode. This effect can be maintained up to 3 to 5\u2009hours, even after stopping its application. Our results suggest that a solution containing hyaluronic acid could be used as an esophageal protector after accidental ingestion of button batteries.<\/jats:p>","DOI":"10.1055\/a-2123-5214","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T23:20:37Z","timestamp":1688599237000},"page":"056-062","source":"Crossref","is-referenced-by-count":4,"title":["Can We Do Anything Else before Removing a Button Battery from the Esophagus?\u2014Hyaluronic Acid"],"prefix":"10.1055","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3434-3442","authenticated-orcid":false,"given":"I.","family":"Bada-Bosch","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.D.","family":"Blanco Verd\u00fa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Cerd\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fanjul","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3730-6719","authenticated-orcid":false,"given":"J.","family":"Ordo\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Tol\u00edn Hernani","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Hospital Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Miranda Cid","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Hospital Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"S\u00e1nchez S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Hospital Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"De Agust\u00edn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.ijporl.2013.06.006","article-title":"Pediatric button battery injuries: 2013 task force update","volume":"77","author":"K R Jatana","year":"2013","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/MPG.0000000000002649","article-title":"Mitigating risks of swallowed button batteries: new strategies before and after removal","volume":"70","author":"D G Lerner","year":"2020","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/lio2.535","article-title":"Current management of button battery injuries","volume":"6","author":"R Sethia","year":"2021","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/MPG.0000000000000729","article-title":"Management of ingested foreign bodies in children: a clinical report of the NASPGHAN Endoscopy Committee","volume":"60","author":"R E Kramer","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/MPG.0000000000003048","article-title":"Diagnosis, management, and prevention of button battery ingestion in childhood: a European Society for Paediatric Gastroenterology Hepatology and Nutrition Position Paper","volume":"73","author":"A Mubarak","year":"2021","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"03","key":"ref6","first-page":"102401","article-title":"Pediatric button battery ingestion: publication trends in the literature","volume":"41","author":"N Haddad","year":"2020","journal-title":"Am J Otolaryngol - 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