{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:12Z","timestamp":1740126852588,"version":"3.37.3"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003A Disintegrin and Metalloproteinase with Thrombospondin-9 (ADAMTS-9), one of the ADAMTS enzymes, is expressed in all fetal tissues, unlike other ADAMTS enzymes, and is thus thought to play a role in fetal development. In this context, the objective of this study is to investigate the relationship between ADAMTS-9 activity and the development of congenital heart diseases (CHD) with a view to using ADAMTS-9 level as a biomarker for CHDs.<\/jats:p><jats:p>\n            Study Design\u2003Newborns diagnosed with CHD and healthy newborns were included in the study as the CHD and control groups, respectively. Gestational age, maternal age, and mode of delivery information pertaining to the mothers and Apgar score and birthweight information pertaining to the newborns were recorded. Blood samples were taken from all newborns to determine their ADAMTS-9 levels in the first 24\u2009hours of life.<\/jats:p><jats:p>\n            Results\u2003Fifty-eight newborns with CHD and 46 healthy newborns were included in the study. Median ADAMTS-9 levels were 46.57 (interquartile range [IQR]: 33.31 [min: 26.92, max: 124.25]) and 23.36 (IQR: 5.48 [min: 11.7, max: 37.71]) ng\/mL in the CHD and control groups, respectively. ADAMTS-9 levels in the CHD group were statistically significantly higher than in the control group (p\u2009=\u20090.000). ADAMTS-9 levels of the CHD and control groups were analyzed by the receiver operating characteristics curve. The area under the curve value for ADAMTS-9 levels of &gt;27.86\u2009ng\/mL as the cut-off value for predicting the development of CHD in newborns was 0.836 (95% confidence interval [CI]: 0.753\u20130.900, p\u2009=\u20090.0001). ADAMTS-9 levels of &gt;27.86\u2009ng\/mL were determined to predict the development of CHD in newborns with a sensitivity of 77.78% (95% CI: 65.5\u201387.38) and a specificity of 84.78% (95% CI: 71.1\u201393.60).<\/jats:p><jats:p>\n            Conclusion\u2003In conclusion, it was found that the serum ADAMTS-9 levels were significantly higher in newborns with CHD than in healthy newborns. In parallel, ADAMTS-9 levels above a certain cut-off value were associated with CHD.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2125-1330","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T22:55:25Z","timestamp":1688770525000},"page":"e2555-e2561","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Serum ADAMTS-9 Level in Newborn Babies with Congenital Heart Disease"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-2595","authenticated-orcid":false,"given":"Cem","family":"Becerir","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Ankara City Hospital, Neonatal Intensive Care Unit, University of Health Sciences, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9970-0714","authenticated-orcid":false,"given":"C\u00fcneyt","family":"Tayman","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Ankara City Hospital, Neonatal Intensive Care Unit, University of Health Sciences, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4430-444X","authenticated-orcid":false,"given":"Abdullah","family":"Kurt","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Yildirim Beyazit University Faculty of Medicine, Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9409-185X","authenticated-orcid":false,"given":"Ufuk","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Ankara City Hospital, Neonatal Intensive Care Unit, University of Health Sciences, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-4757","authenticated-orcid":false,"given":"\u0130smail","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Harran University, Urfa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5914-5325","authenticated-orcid":false,"given":"Burak","family":"Ceran","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Ankara City Hospital, Neonatal Intensive Care Unit, University of Health Sciences, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8923-8709","authenticated-orcid":false,"given":"Kenan","family":"Toprak","sequence":"additional","affiliation":[{"name":"Cardiology Department, Faculty of Medicine, Harran University, \u015eanl\u0131urfa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-4058","authenticated-orcid":false,"given":"Murat","family":"K\u0131z\u0131lg\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Sa\u011fl\u0131k Bilimleri \u00dcniversitesi G\u00fclhane T\u0131p Fak\u00fcltesi, Health Science University Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"issue":"23","key":"ref1","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1161\/CIRCULATIONAHA.106.183216","article-title":"Noninherited risk factors and congenital cardiovascular defects: current knowledge: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics","volume":"115","author":"K J Jenkins","year":"2007","journal-title":"Circulation"},{"issue":"21","key":"ref2","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1161\/CIR.0000000000000606","article-title":"Genetic basis for congenital heart disease: revisited: a scientific statement from the American Heart Association","volume":"138","author":"M E Pierpont","year":"2018","journal-title":"Circulation"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/ije\/dyz009","article-title":"Global birth prevalence of congenital heart defects 1970-2017: updated systematic review and meta-analysis of 260 studies","volume":"48","author":"Y Liu","year":"2019","journal-title":"Int J Epidemiol"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.clp.2015.02.009","article-title":"Genetics and genetic testing in congenital heart disease","volume":"42","author":"J R Cowan","year":"2015","journal-title":"Clin 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binds to and degrades cartilage oligomeric matrix protein","volume":"20","author":"C J Liu","year":"2006","journal-title":"FASEB J"},{"issue":"23","key":"ref12","doi-asserted-by":"crossref","first-page":"15800","DOI":"10.1074\/jbc.M513433200","article-title":"ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein","volume":"281","author":"C J Liu","year":"2006","journal-title":"J Biol Chem"},{"issue":"34","key":"ref13","doi-asserted-by":"crossref","first-page":"35159","DOI":"10.1074\/jbc.M402380200","article-title":"ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain","volume":"279","author":"R P Somerville","year":"2004","journal-title":"J Biol Chem"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1006\/geno.2000.6246","article-title":"ADAMTS9, a novel member of the ADAM-TS\/ metallospondin gene family","volume":"67","author":"M E Clark","year":"2000","journal-title":"Genomics"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.matbio.2010.01.005","article-title":"Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies","volume":"29","author":"C B Kern","year":"2010","journal-title":"Matrix Biol"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/ajmg.c.31759","article-title":"The genetic workup for structural congenital heart disease","volume":"184","author":"T Jerves","year":"2020","journal-title":"Am J Med Genet C Semin Med Genet"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1038\/ng.3970","article-title":"Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands","volume":"49","author":"S C Jin","year":"2017","journal-title":"Nat 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