{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:42:55Z","timestamp":1778938975531,"version":"3.51.4"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["DFG-CRC1009,DFG-CRC1450-431460824"],"award-info":[{"award-number":["DFG-CRC1009,DFG-CRC1450-431460824"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Purpose Prostate-specific membrane antigen (PSMA) is present in the proximal tubule cells of the kidneys. This results in high renal tracer uptake in PSMA-PET, which may contain useful information on renal function. As part of the evaluation for [177Lu]-PSMA therapies, patients undergo PSMA-PET and additional [99mTc]-mercapto-acetyltriglycine (MAG3) scintigraphy to assess renal function. Aim of this study was to evaluate estimation of renal function with [18F]-PSMA-1007-PET\/CT (PSMA-PET) by comparison to timely MAG3-scintigraphies.<\/jats:p><jats:p>\n            Materials and Methods We retrospectively investigated 73 prostate cancer patients with 93 timely available PSMA-PET\/CT, MAG3-scintigraphies and serum creatinine. For determination of split renal function in PSMA-PET\/CT, we evaluated the relative unilateral total renal PSMA uptake, i.e. SUVmean multiplied by the renal volume (SRFPSMA-TOTAL) and relative unilateral maximal standardized uptake value (SRFSUV). These were compared to MAG3 split renal function (SRFMAG3) using Pearson correlation and receiver operating characteristics analysis. For determination of global renal function, correlation of bilateral total renal PSMA uptake with MAG3 tubular excretion rate and serum creatinine was assessed.<\/jats:p><jats:p>\n            Results SRFMAG3 was strongly correlated with SRFPSMA-TOTAL (r= 0.872, p&lt;0.001) and with SRFSUV (r=0.815, p&lt;0.001). Relevant abnormalities of SRFMAG3 (unilateral renal function &lt; 25 %) could be detected with sensitivities and specificities of 90% and 92% for SRFPSMA-TOTAL, and 80% and 95% for SRFSUV. Measures of absolute renal function were only weakly correlated with bilateral total renal PSMA uptake.<\/jats:p><jats:p>\n            Conclusion Renal [18F]-PSMA-1007 uptake allowed to quantify renal split function with good accuracy based on SRFPSMA-TOTAL or SRFSUV.<\/jats:p>","DOI":"10.1055\/a-2127-7880","type":"journal-article","created":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T22:52:52Z","timestamp":1692399172000},"page":"244-251","source":"Crossref","is-referenced-by-count":11,"title":["[18F]-PSMA-1007-PET for evaluation of kidney function"],"prefix":"10.1055","volume":"62","author":[{"given":"Philipp","family":"Rassek","sequence":"additional","affiliation":[{"name":"Clinic for Nuclear Medicine, Universitiy Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sch\u00e4fers","sequence":"additional","affiliation":[{"name":"Clinic for Nuclear Medicine, Universitiy Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kambiz","family":"Rahbar","sequence":"additional","affiliation":[{"name":"Clinic for Nuclear Medicine, Universitiy Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Backhaus","sequence":"additional","affiliation":[{"name":"Clinic for Nuclear Medicine, Universitiy Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1536012118776068","DOI":"10.1177\/1536012118776068","article-title":"PSMA Theranostics: Current Status and Future Directions","volume":"17","author":"K Rahbar","year":"2018","journal-title":"Mol Imaging"},{"issue":"05","key":"ref2","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1007\/s00259-017-3922-y","article-title":"Targeting PSMA by radioligands in non-prostate disease-current status and future perspectives","volume":"45","author":"P Backhaus","year":"2018","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"01","key":"ref3","first-page":"81","article-title":"Prostate-specific membrane antigen expression in normal and malignant human tissues","volume":"3","author":"DA Silver","year":"1997","journal-title":"Clin Cancer Res"},{"issue":"01","key":"ref4","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s00259-015-3174-7","article-title":"Dosimetry for (177)Lu-DKFZ-PSMA-617: a new radiopharmaceutical for the treatment of metastatic prostate cancer","volume":"43","author":"A Delker","year":"2016","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"01","key":"ref5","doi-asserted-by":"publisher","first-page":"F145","DOI":"10.1152\/ajprenal.00164.2016","article-title":"The proximal tubule is the primary target of injury and progression of kidney disease: role of the glomerulotubular junction","volume":"311","author":"RL Chevalier","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"issue":"12","key":"ref6","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1007\/s00259-019-04485-3","article-title":"EANM procedure guidelines for radionuclide therapy with\u00a0177Lu-labelled PSMA-ligands (177Lu-PSMA-RLT)","volume":"46","author":"C Kratochwil","year":"2019","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"02","key":"ref7","doi-asserted-by":"publisher","first-page":"230","DOI":"10.23736\/S0393-2249.18.03091-6","article-title":"Non-invasive method for assessing split renal function","volume":"70","author":"DA Cozzi","year":"2018","journal-title":"Minerva Urol Nefrol"},{"issue":"12","key":"ref8","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1007\/s00259-018-4129-6","article-title":"The SNMMI and EANM practice guideline for renal scintigraphy in adults","volume":"45","author":"MD Blaufox","year":"2018","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"05","key":"ref9","first-page":"249","article-title":"Determination of split renal function by PSMA imaging: comparison of\u00a068Ga-PSMA-11 PET with\u00a099mTc-MAG3 scintigraphy","volume":"10","author":"F Rosar","year":"2020","journal-title":"Am J Nucl Med Mol Imaging"},{"issue":"01","key":"ref10","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s40658-021-00419-x","article-title":"Dose-reduced [18F]PSMA-1007 PET is feasible for functional imaging of the renal cortex","volume":"8","author":"K Valind","year":"2021","journal-title":"EJNMMI Phys"},{"issue":"04","key":"ref11","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3390\/ph10040077","article-title":"Procedures for the GMP-Compliant Production and Quality Control of [18F]PSMA-1007: A Next Generation Radiofluorinated Tracer for the Detection of Prostate Cancer","volume":"10","author":"J Cardinale","year":"2017","journal-title":"Pharmaceuticals (Basel)"},{"issue":"09","key":"ref12","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1007\/s00345-018-2595-x","article-title":"Donor kidney volume measured by computed tomography is a strong predictor of recipient eGFR in living donor kidney transplantation","volume":"37","author":"DP Al-Adra","year":"2019","journal-title":"World J Urol"},{"issue":"01","key":"ref13","doi-asserted-by":"publisher","first-page":"16","DOI":"10.6002\/ect.2016.0272","article-title":"Validation of Ultrasonographic Kidney Volume Measurements: A Reliable Imaging Modality","volume":"16","author":"S Janki","year":"2018","journal-title":"Exp Clin Transplant"},{"issue":"07","key":"ref14","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1016\/j.transproceed.2019.02.039","article-title":"Is There a Correlation with Pre-donation Kidney Volume and Renal Function in the Renal Transplant Recipient?: A Volumetric Computed Tomography Study","volume":"51","author":"AG Coruh","year":"2019","journal-title":"Transplant Proc"},{"issue":"06","key":"ref15","first-page":"1066","article-title":"Reproducibility of technetium-99m-MAG3 clearance using the Bubeck method","volume":"39","author":"E Werner","year":"1998","journal-title":"J Nucl Med"},{"issue":"11","key":"ref16","first-page":"1199","article-title":"Quantification of renal function with 99mTc-MAG3--quantification of tubular extraction rate using Bubeck\u2019s method","volume":"32","author":"T Yamazaki","year":"1995","journal-title":"Kaku Igaku"},{"key":"ref17","first-page":"972","article-title":"Relative 99mTc-MAG3 renal uptake: reproducibility and accuracy","volume":"40","author":"A Piepsz","year":"1999","journal-title":"J Nucl Med"},{"issue":"02","key":"ref18","doi-asserted-by":"publisher","first-page":"226","DOI":"10.2967\/jnumed.121.261906","article-title":"Tumor Sink Effect in\u00a068Ga-PSMA-11 PET: Myth or Reality?","volume":"63","author":"A Gafita","year":"2022","journal-title":"J Nucl Med"},{"issue":"04","key":"ref19","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1053\/j.semnuclmed.2021.12.003","article-title":"SPECT and PET Radiotracers in Renal Imaging","volume":"52","author":"RA Werner","year":"2022","journal-title":"Semin Nucl Med"},{"issue":"12","key":"ref20","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1007\/s00259-018-4129-6","article-title":"The SNMMI and EANM practice guideline for renal scintigraphy in adults","volume":"45","author":"MD Blaufox","year":"2018","journal-title":"Eur J Nucl Med Mol 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Auflage","author":"H Schicha","year":"2007"}],"container-title":["Nuklearmedizin - NuclearMedicine"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2127-7880.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T23:26:15Z","timestamp":1693869975000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2127-7880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":22,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2023,9,4]]},"published-print":{"date-parts":[[2023,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2127-7880","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0029-5566","2567-6407"],"issn-type":[{"value":"0029-5566","type":"print"},{"value":"2567-6407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]}}}