{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:37:44Z","timestamp":1792013864801,"version":"4.4.0"},"reference-count":159,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"DOI":"10.13039\/100005347","name":"American Association for the Study of Liver Diseases","doi-asserted-by":"crossref","award":["Pinnacle Research Award"],"award-info":[{"award-number":["Pinnacle Research Award"]}],"id":[{"id":"10.13039\/100005347","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017784","name":"Gilead Research Scholars","doi-asserted-by":"crossref","award":["Liver Scholar Award"],"award-info":[{"award-number":["Liver Scholar Award"]}],"id":[{"id":"10.13039\/100017784","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["5T32DK124190,P30DK084567"],"award-info":[{"award-number":["5T32DK124190,P30DK084567"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Liver Dis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>Liver sinusoidal endothelial cells (LSECs) are key players in maintaining hepatic homeostasis. They also play crucial roles during liver injury by communicating with liver cell types as well as immune cells and promoting portal hypertension, fibrosis, and inflammation. Cutting-edge technology, such as single cell and spatial transcriptomics, have revealed the existence of distinct LSEC subpopulations with a clear zonation in the liver. The signals released by LSECs are commonly called \u201cangiocrine signaling.\u201d In this review, we summarize the role of angiocrine signaling in health and disease, including zonation in healthy liver, regeneration, fibrosis, portal hypertension, nonalcoholic fatty liver disease, alcohol-associated liver disease, aging, drug-induced liver injury, and ischemia\/reperfusion, as well as potential therapeutic advances. In conclusion, sinusoidal endotheliopathy is recognized in liver disease and promising preclinical studies are paving the path toward LSEC-specific pharmacotherapies.<\/jats:p>","DOI":"10.1055\/a-2128-5907","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T18:52:08Z","timestamp":1689274328000},"page":"245-257","source":"Crossref","is-referenced-by-count":14,"title":["Angiocrine Signaling in Sinusoidal Health and Disease"],"prefix":"10.1055","volume":"43","author":[{"given":"Shawna A.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enis","family":"Kostallari","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay H.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1002\/hep.27376","article-title":"Liver sinusoidal endothelial cells in hepatic fibrosis","volume":"61","author":"L D DeLeve","year":"2015","journal-title":"Hepatology"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/aja.1001440304","article-title":"Scanning electron microscopy of normal rat liver: the surface structure of its cells and tissue components","volume":"144","author":"J W Grisham","year":"1975","journal-title":"Am J Anat"},{"issue":"06","key":"ref3","first-page":"590","article-title":"Ultrastructure of hepatocellular carcinoma in a cirrhotic liver","volume":"13","author":"N Livni","year":"1977","journal-title":"Isr J Med Sci"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2016.07.009","article-title":"Liver sinusoidal endothelial cells: Physiology and role in liver diseases","volume":"66","author":"J Poisson","year":"2017","journal-title":"J Hepatol"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"G246","DOI":"10.1152\/ajpgi.00118.2016","article-title":"Angiocrine signaling in the hepatic sinusoids in health and disease","volume":"311","author":"E Kostallari","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"02","key":"ref6","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/HEP.0000000000000207","article-title":"The evolving role of liver sinusoidal endothelial cells in liver health and disease","volume":"78","author":"M J McConnell","year":"2023","journal-title":"Hepatology"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0022-5320(70)90150-4","article-title":"An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids","volume":"31","author":"E Wisse","year":"1970","journal-title":"J Ultrastruct Res"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nbt.4231","article-title":"Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells","volume":"36","author":"K B Halpern","year":"2018","journal-title":"Nat Biotechnol"},{"issue":"08","key":"ref9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41575-020-0304-x","article-title":"Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis","volume":"17","author":"P Ramachandran","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.devcel.2021.05.001","article-title":"A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver","volume":"56","author":"D Inverso","year":"2021","journal-title":"Dev Cell"},{"issue":"02","key":"ref11","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/hep.29834","article-title":"Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice","volume":"68","author":"J L Duan","year":"2018","journal-title":"Hepatology"},{"issue":"06","key":"ref12","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.jcmgh.2022.01.019","article-title":"Notch-regulated c-Kit-positive liver sinusoidal endothelial cells contribute to liver zonation and regeneration","volume":"13","author":"J L Duan","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"05","key":"ref13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41580-022-00481-y","article-title":"Endothelial cell diversity in the liver","volume":"23","author":"K Baumann","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"04","key":"ref14","doi-asserted-by":"crossref","first-page":"G803","DOI":"10.1152\/ajpgi.00215.2019","article-title":"Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization","volume":"318","author":"W de Haan","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.stem.2022.03.002","article-title":"Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction","volume":"29","author":"J M G\u00f3mez-Salinero","year":"2022","journal-title":"Cell Stem Cell"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10456-021-09780-y","article-title":"Angiodiversity and organotypic functions of sinusoidal endothelial cells","volume":"24","author":"P S Koch","year":"2021","journal-title":"Angiogenesis"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.jcmgh.2022.02.010","article-title":"Liver endothelial Heg regulates vascular\/biliary network patterning and metabolic zonation via Wnt signaling","volume":"13","author":"S Zhu","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"722394","DOI":"10.3389\/fphys.2021.722394","article-title":"Imbalanced activation of Wnt-\/\u03b2-catenin-signaling in liver endothelium alters normal sinusoidal differentiation","volume":"12","author":"P S Koch","year":"2021","journal-title":"Front Physiol"},{"issue":"02","key":"ref19","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/hep.29613","article-title":"Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice","volume":"68","author":"T Leibing","year":"2018","journal-title":"Hepatology"},{"issue":"02","key":"ref20","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jhep.2020.09.003","article-title":"Liver zonation","volume":"74","author":"R Manco","year":"2021","journal-title":"J Hepatol"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/hep.32408","article-title":"Liver zonation, revisited","volume":"76","author":"J Paris","year":"2022","journal-title":"Hepatology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"102027","DOI":"10.1016\/j.tice.2023.102027","article-title":"Liver angiocrine factors","volume":"81","author":"D Ribatti","year":"2023","journal-title":"Tissue Cell"},{"issue":"01","key":"ref23","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"S A MacParland","year":"2018","journal-title":"Nat Commun"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jcmgh.2020.12.007","article-title":"Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis","volume":"11","author":"T Su","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"06","key":"ref25","first-page":"4845","article-title":"CXCL9 regulates acetaminophen-induced liver injury via CXCR3","volume":"18","author":"X Song","year":"2019","journal-title":"Exp Ther Med"},{"issue":"04","key":"ref26","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.immuni.2019.08.017","article-title":"Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche","volume":"51","author":"J Bonnardel","year":"2019","journal-title":"Immunity"},{"issue":"02","key":"ref27","doi-asserted-by":"crossref","first-page":"112046","DOI":"10.1016\/j.celrep.2023.112046","article-title":"Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes","volume":"42","author":"A Gainullina","year":"2023","journal-title":"Cell Rep"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"M Guilliams","year":"2022","journal-title":"Cell"},{"issue":"07","key":"ref29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nri.2017.42","article-title":"Does niche competition determine the origin of tissue-resident macrophages?","volume":"17","author":"M Guilliams","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"10321","DOI":"10.1038\/ncomms10321","article-title":"Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells","volume":"7","author":"C L Scott","year":"2016","journal-title":"Nat Commun"},{"issue":"04","key":"ref31","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.immuni.2016.02.017","article-title":"Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages","volume":"44","author":"L van de Laar","year":"2016","journal-title":"Immunity"},{"issue":"09","key":"ref32","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.immuni.2022.08.002","article-title":"Liver macrophages in health and disease","volume":"55","author":"M Guilliams","year":"2022","journal-title":"Immunity"},{"issue":"04","key":"ref33","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/hep4.1854","article-title":"Single-cell, single-nucleus, and spatial RNA sequencing of the human liver identifies cholangiocyte and mesenchymal heterogeneity","volume":"6","author":"T S Andrews","year":"2022","journal-title":"Hepatol Commun"},{"issue":"07","key":"ref34","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.celrep.2019.10.024","article-title":"Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis","volume":"29","author":"R Dobie","year":"2019","journal-title":"Cell Rep"},{"issue":"02","key":"ref35","doi-asserted-by":"crossref","first-page":"G234","DOI":"10.1152\/ajpgi.00254.2021","article-title":"Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis","volume":"322","author":"E Kostallari","year":"2022","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"P Ramachandran","year":"2019","journal-title":"Nature"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1089\/ars.2021.0048","article-title":"The aging liver: redox biology and liver regeneration","volume":"35","author":"F Bellanti","year":"2021","journal-title":"Antioxid Redox Signal"},{"issue":"06","key":"ref38","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.stem.2022.04.008","article-title":"The spatiotemporal program of zonal liver regeneration following acute injury","volume":"29","author":"S Ben-Moshe","year":"2022","journal-title":"Cell Stem Cell"},{"issue":"11","key":"ref39","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/stcltm\/szac070","article-title":"Comprehensive review of the vascular niche in regulating organ regeneration and fibrosis","volume":"11","author":"Y Chen","year":"2022","journal-title":"Stem Cells Transl Med"},{"issue":"02","key":"ref40","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cmet.2020.11.019","article-title":"Aging reprograms the hematopoietic-vascular niche to impede regeneration and promote fibrosis","volume":"33","author":"Y Chen","year":"2021","journal-title":"Cell Metab"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature12681","article-title":"Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis","volume":"505","author":"B S Ding","year":"2014","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nature09493","article-title":"Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration","volume":"468","author":"B S Ding","year":"2010","journal-title":"Nature"},{"issue":"17","key":"ref43","doi-asserted-by":"crossref","first-page":"9868","DOI":"10.3390\/ijms23179868","article-title":"An eye on Kupffer cells: development, phenotype and the macrophage niche","volume":"23","author":"A Elchaninov","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"09","key":"ref44","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1515\/hsz-2021-0155","article-title":"Role of vasodilation in liver regeneration and health","volume":"402","author":"L Gro\u00dfe-Segerath","year":"2021","journal-title":"Biol Chem"},{"issue":"10","key":"ref45","doi-asserted-by":"crossref","first-page":"100754","DOI":"10.1016\/j.xcrm.2022.100754","article-title":"Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b","volume":"3","author":"S Hu","year":"2022","journal-title":"Cell Rep Med"},{"issue":"02","key":"ref46","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/hep.27116","article-title":"Sinusoidal endothelial cells direct traffic at the intersection of regeneration and fibrosis","volume":"60","author":"R C Huebert","year":"2014","journal-title":"Hepatology"},{"issue":"02","key":"ref47","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/hep.31759","article-title":"Gene deconvolution reveals aberrant liver regeneration and immune cell infiltration in alcohol-associated hepatitis","volume":"74","author":"A Kim","year":"2021","journal-title":"Hepatology"},{"key":"ref48","first-page":"9","article-title":"Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts","volume":"9","author":"R Ma","year":"2020","journal-title":"eLife"},{"issue":"03","key":"ref49","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri3623","article-title":"Liver fibrosis and repair: immune regulation of wound healing in a solid organ","volume":"14","author":"A Pellicoro","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"03","key":"ref50","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.tcb.2014.11.007","article-title":"Regulation of tissue morphogenesis by endothelial cell-derived signals","volume":"25","author":"S K Ramasamy","year":"2015","journal-title":"Trends Cell Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"16044","DOI":"10.1038\/sigtrans.2016.44","article-title":"Platelets prime hematopoietic and vascular niche to drive angiocrine-mediated liver regeneration","volume":"2","author":"K Shido","year":"2017","journal-title":"Signal Transduct Target Ther"},{"issue":"01","key":"ref52","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1253\/circj.CJ-18-1180","article-title":"Discovery of a vascular endothelial stem cell (VESC) population required for vascular regeneration and tissue maintenance","volume":"83","author":"N Takakura","year":"2018","journal-title":"Circ J"},{"issue":"10","key":"ref53","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.3390\/ijms21103606","article-title":"The role of autophagy for the regeneration of the aging liver","volume":"21","author":"F Xu","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"02","key":"ref54","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ajpath.2019.10.009","article-title":"Angiocrine hepatocyte growth factor signaling controls physiological organ and body size and dynamic hepatocyte proliferation to prevent liver damage during regeneration","volume":"190","author":"X J Zhang","year":"2020","journal-title":"Am J Pathol"},{"issue":"01","key":"ref55","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13619-022-00152-5","article-title":"ScRNA-seq and ST-seq in liver research","volume":"12","author":"J He","year":"2023","journal-title":"Cell Regen (Lond)"},{"issue":"05","key":"ref56","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1006\/niox.2001.0373","article-title":"Shear stress-induced nitric oxide release triggers the liver regeneration cascade","volume":"5","author":"J M Schoen","year":"2001","journal-title":"Nitric Oxide"},{"issue":"11","key":"ref57","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1172\/JCI119842","article-title":"Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids","volume":"100","author":"V Shah","year":"1997","journal-title":"J Clin Invest"},{"issue":"02","key":"ref58","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/hep.22660","article-title":"Evidence for LKB1\/AMP-activated protein kinase\/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation","volume":"49","author":"M V\u00e1zquez-Chantada","year":"2009","journal-title":"Hepatology"},{"issue":"01","key":"ref59","first-page":"e22125","article-title":"Endothelial dysfunction in pathological processes of chronic liver disease during aging","volume":"36","author":"Y Wan","year":"2022","journal-title":"FASEB J"},{"issue":"06","key":"ref60","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1002\/hep.28809","article-title":"Hypoxia-driven Hif2a coordinates mouse liver regeneration by coupling parenchymal growth to vascular expansion","volume":"64","author":"P Kron","year":"2016","journal-title":"Hepatology"},{"issue":"05","key":"ref61","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1073\/pnas.85.5.1539","article-title":"Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation","volume":"85","author":"L Braun","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"01","key":"ref62","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jhep.2020.02.005","article-title":"Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12","volume":"73","author":"J P Arab","year":"2020","journal-title":"J Hepatol"},{"issue":"24","key":"ref63","doi-asserted-by":"crossref","first-page":"e92821","DOI":"10.1172\/jci.insight.92821","article-title":"Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms","volume":"2","author":"M C Drinane","year":"2017","journal-title":"JCI Insight"},{"issue":"05","key":"ref64","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jhep.2020.04.044","article-title":"Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis","volume":"73","author":"J Gao","year":"2020","journal-title":"J Hepatol"},{"issue":"01","key":"ref65","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/hep.29803","article-title":"Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2","volume":"68","author":"E Kostallari","year":"2018","journal-title":"Hepatology"},{"issue":"03","key":"ref66","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/hep.28921","article-title":"The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice","volume":"65","author":"J L Maiers","year":"2017","journal-title":"Hepatology"},{"issue":"03","key":"ref67","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jcmgh.2020.05.005","article-title":"GIPC-regulated IGFBP-3 promotes HSC migration in vitro and portal hypertension in vivo through a \u03b21-integrin pathway","volume":"10","author":"U Yaqoob","year":"2020","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"06","key":"ref68","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1002\/hep.31617","article-title":"Endothelial p300 promotes portal hypertension and hepatic fibrosis through C-C motif chemokine ligand 2-mediated angiocrine signaling","volume":"73","author":"J Gao","year":"2021","journal-title":"Hepatology"},{"issue":"01","key":"ref69","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1053\/j.gastro.2019.03.013","article-title":"Mechanical stretch increases expression of CXCL1 in liver sinusoidal endothelial cells to recruit neutrophils, generate sinusoidal microthombi, and promote portal hypertension","volume":"157","author":"M B Hilscher","year":"2019","journal-title":"Gastroenterology"},{"issue":"06","key":"ref70","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41575-020-00411-3","article-title":"Role of liver sinusoidal endothelial cells in liver diseases","volume":"18","author":"J Gracia-Sancho","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"04","key":"ref71","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41575-018-0097-3","article-title":"Hepatic microcirculation and mechanisms of portal hypertension","volume":"16","author":"J Gracia-Sancho","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"26","key":"ref72","doi-asserted-by":"crossref","first-page":"18163","DOI":"10.1074\/jbc.M113.521203","article-title":"Endothelial nitric-oxide synthase (eNOS) is activated through G-protein-coupled receptor kinase-interacting protein 1 (GIT1) tyrosine phosphorylation and Src protein","volume":"289","author":"S Liu","year":"2014","journal-title":"J Biol Chem"},{"issue":"03","key":"ref73","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/hep.22351","article-title":"Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence","volume":"48","author":"L D Deleve","year":"2008","journal-title":"Hepatology"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-3-030-11093-2_9","article-title":"Pericytes in the liver","volume":"1122","author":"E Kostallari","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"ref75","first-page":"S0168","article-title":"An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH","author":"F Tacke","year":"2023","journal-title":"J Hepatol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"671081","DOI":"10.3389\/fcell.2021.671081","article-title":"Capillarized liver sinusoidal endothelial cells undergo partial endothelial-mesenchymal transition to actively deposit sinusoidal ECM in liver fibrosis","volume":"9","author":"B Ruan","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"02","key":"ref77","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jhep.2020.08.033","article-title":"Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling","volume":"74","author":"M Winkler","year":"2021","journal-title":"J Hepatol"},{"issue":"07","key":"ref78","doi-asserted-by":"crossref","first-page":"e20201745","DOI":"10.1084\/jem.20201745","article-title":"GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension","volume":"218","author":"K Drzewiecki","year":"2021","journal-title":"J Exp Med"},{"issue":"06","key":"ref79","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.cell.2019.07.021","article-title":"LECT2, a ligand for Tie1, plays a crucial role in liver fibrogenesis","volume":"178","author":"M Xu","year":"2019","journal-title":"Cell"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/j.jhep.2015.01.003","article-title":"Evolution in the understanding of the pathophysiological basis of portal hypertension: how changes in paradigm are leading to successful new treatments","volume":"62","author":"J Bosch","year":"2015","journal-title":"J Hepatol"},{"issue":"S 01","key":"ref81","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.jhep.2021.01.002","article-title":"Pathophysiology of decompensated cirrhosis: portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction","volume":"75","author":"C Engelmann","year":"2021","journal-title":"J Hepatol"},{"issue":"40","key":"ref82","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.3748\/wjg.v26.i40.6111","article-title":"Cirrhotic portal hypertension: from pathophysiology to novel therapeutics","volume":"26","author":"L S Gunarathne","year":"2020","journal-title":"World J Gastroenterol"},{"issue":"04","key":"ref83","doi-asserted-by":"crossref","first-page":"100316","DOI":"10.1016\/j.jhepr.2021.100316","article-title":"Portal hypertension in cirrhosis: pathophysiological mechanisms and therapy","volume":"3","author":"Y Iwakiri","year":"2021","journal-title":"JHEP Rep"},{"issue":"03","key":"ref84","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/01.RES.0000136519.84279.7a","article-title":"Ceramide triggers Weibel-Palade body exocytosis","volume":"95","author":"R Bhatia","year":"2004","journal-title":"Circ Res"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0083-6729(08)60639-1","article-title":"Nitric oxide and platelet aggregation","volume":"57","author":"D R Riddell","year":"1999","journal-title":"Vitam Horm"},{"issue":"03","key":"ref86","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jhep.2022.03.029","article-title":"Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo","volume":"77","author":"T Greuter","year":"2022","journal-title":"J Hepatol"},{"issue":"03","key":"ref87","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jhep.2018.10.033","article-title":"Non-alcoholic fatty liver disease - a global public health perspective","volume":"70","author":"Z M Younossi","year":"2019","journal-title":"J Hepatol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fphys.2019.00006","article-title":"LSEC fenestrae are preserved despite pro-inflammatory phenotype of liver sinusoidal endothelial cells in mice on high fat diet","volume":"10","author":"E Kus","year":"2019","journal-title":"Front Physiol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"983255","DOI":"10.3389\/fimmu.2022.983255","article-title":"Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis","volume":"13","author":"Q Guo","year":"2022","journal-title":"Front Immunol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"120355","DOI":"10.1016\/j.lfs.2022.120355","article-title":"Endothelial group IVA phospholipase A2 promotes hepatic fibrosis with sinusoidal capillarization in the early stage of non-alcoholic steatohepatitis in mice","volume":"294","author":"E Kawashita","year":"2022","journal-title":"Life Sci"},{"issue":"10","key":"ref91","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/labinvest.2015.95","article-title":"Pivotal role of liver sinusoidal endothelial cells in NAFLD\/NASH progression","volume":"95","author":"M Miyao","year":"2015","journal-title":"Lab Invest"},{"issue":"02","key":"ref92","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.pathol.2020.07.018","article-title":"Electron microscopic observations in perfusion-fixed human non-alcoholic fatty liver disease biopsies","volume":"53","author":"P Verhaegh","year":"2021","journal-title":"Pathology"},{"issue":"10","key":"ref93","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/labinvest.2012.103","article-title":"Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture","volume":"92","author":"S Francque","year":"2012","journal-title":"Lab Invest"},{"issue":"04","key":"ref94","doi-asserted-by":"crossref","first-page":"e32785","DOI":"10.1371\/journal.pone.0032785","article-title":"Sinusoidal endothelial dysfunction precedes inflammation and fibrosis in a model of NAFLD","volume":"7","author":"M Pasar\u00edn","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"ref95","doi-asserted-by":"crossref","first-page":"e003896","DOI":"10.1161\/JAHA.116.003896","article-title":"Clinical adverse effects of endothelin receptor antagonists: insights from the meta-analysis of 4894 patients from 24 randomized double-blind placebo-controlled clinical trials","volume":"5","author":"A Wei","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"03","key":"ref96","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/hep.32332","article-title":"Notch-triggered maladaptation of liver sinusoidal endothelium aggravates nonalcoholic steatohepatitis through endothelial nitric oxide synthase","volume":"76","author":"Z Q Fang","year":"2022","journal-title":"Hepatology"},{"issue":"06","key":"ref97","doi-asserted-by":"crossref","first-page":"e143690","DOI":"10.1172\/JCI143690","article-title":"Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis","volume":"131","author":"K Furuta","year":"2021","journal-title":"J Clin Invest"},{"issue":"11","key":"ref98","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1016\/j.celrep.2017.02.039","article-title":"Roles for cell-cell adhesion and contact in obesity-induced hepatic myeloid cell accumulation and glucose intolerance","volume":"18","author":"Y Miyachi","year":"2017","journal-title":"Cell Rep"},{"issue":"02","key":"ref99","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1172\/JCI73722","article-title":"Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis","volume":"125","author":"C J Weston","year":"2015","journal-title":"J Clin Invest"},{"issue":"01","key":"ref100","doi-asserted-by":"crossref","first-page":"G67","DOI":"10.1152\/ajpgi.00009.2021","article-title":"Sinusoidal endotheliopathy in nonalcoholic steatohepatitis: therapeutic implications","volume":"321","author":"S H Ibrahim","year":"2021","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"05","key":"ref101","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.jhep.2005.09.020","article-title":"Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides","volume":"44","author":"M Martin-Armas","year":"2006","journal-title":"J Hepatol"},{"issue":"03","key":"ref102","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2567.2009.03179.x","article-title":"Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific","volume":"129","author":"J Wu","year":"2010","journal-title":"Immunology"},{"issue":"01","key":"ref103","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ni.1675","article-title":"The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity","volume":"10","author":"M Pruenster","year":"2009","journal-title":"Nat Immunol"},{"issue":"03","key":"ref104","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jhep.2019.10.028","article-title":"A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis","volume":"72","author":"A Hammoutene","year":"2020","journal-title":"J Hepatol"},{"issue":"04","key":"ref105","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1055\/s-0040-1715446","article-title":"Aging and chronic liver disease","volume":"40","author":"R Maeso-D\u00edaz","year":"2020","journal-title":"Semin Liver Dis"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.arr.2019.02.002","article-title":"The peculiar aging of human liver: a geroscience perspective within transplant context","volume":"51","author":"C Morsiani","year":"2019","journal-title":"Ageing Res Rev"},{"issue":"03","key":"ref107","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1055\/s-0039-3402033","article-title":"Aging and the biological response to liver injury","volume":"40","author":"C Pinto","year":"2020","journal-title":"Semin Liver Dis"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"842024","DOI":"10.3389\/fmed.2022.842024","article-title":"Understanding the unique microenvironment in the aging liver","volume":"9","author":"Y Zhao","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"04","key":"ref109","doi-asserted-by":"crossref","first-page":"684","DOI":"10.14336\/AD.2019.0127","article-title":"Aging influences hepatic microvascular biology and liver fibrosis in advanced chronic liver disease","volume":"10","author":"R Maeso-D\u00edaz","year":"2019","journal-title":"Aging Dis"},{"issue":"01","key":"ref110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/org.6.1.10427","article-title":"Microvascular rarefaction: the decline and fall of blood vessels","volume":"6","author":"M S Goligorsky","year":"2010","journal-title":"Organogenesis"},{"issue":"06","key":"ref111","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1002\/hep.20937","article-title":"Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat","volume":"42","author":"S N Hilmer","year":"2005","journal-title":"Hepatology"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"eabc8479","DOI":"10.1126\/science.abc8479","article-title":"Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span","volume":"373","author":"M Grunewald","year":"2021","journal-title":"Science"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.csbj.2019.07.021","article-title":"Hallmarks of aging in the liver","volume":"17","author":"N J Hunt","year":"2019","journal-title":"Comput Struct Biotechnol J"},{"issue":"04","key":"ref114","doi-asserted-by":"crossref","first-page":"e13131","DOI":"10.1111\/acel.13131","article-title":"Impaired integrin \u03b15\/\u03b21-mediated hepatocyte growth factor release by stellate cells of the aged liver","volume":"19","author":"F Rohn","year":"2020","journal-title":"Aging Cell"},{"key":"ref115","first-page":"439835","article-title":"The effects of old age on hepatic stellate cells","author":"A Warren","year":"2011","journal-title":"Curr Gerontol Geriatr Res"},{"issue":"03","key":"ref116","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jhep.2004.11.033","article-title":"Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen","volume":"42","author":"R S McCuskey","year":"2005","journal-title":"J Hepatol"},{"issue":"02","key":"ref117","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jhep.2021.02.028","article-title":"Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease","volume":"75","author":"Y Yang","year":"2021","journal-title":"J Hepatol"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature21065","article-title":"Single-cell spatial reconstruction reveals global division of labour in the mammalian liver","volume":"542","author":"K B Halpern","year":"2017","journal-title":"Nature"},{"issue":"04","key":"ref119","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF02975435","article-title":"The alcohol-inducible form of cytochrome P450 (CYP 2E1): role in toxicology and regulation of expression","volume":"23","author":"R F Novak","year":"2000","journal-title":"Arch Pharm Res"},{"issue":"12","key":"ref120","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1128\/EC.00189-14","article-title":"Protein acetylation and acetyl coenzyme a metabolism in budding yeast","volume":"13","author":"L Galdieri","year":"2014","journal-title":"Eukaryot Cell"},{"key":"ref121","first-page":"5091275","article-title":"The mechanisms of systemic inflammatory and immunosuppressive acute-on-chronic liver failure and application prospect of single-cell sequencing","author":"K Kou","year":"2022","journal-title":"J Immunol Res"},{"issue":"01","key":"ref122","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1038\/s41467-021-24843-w","article-title":"Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis","volume":"12","author":"M Liu","year":"2021","journal-title":"Nat Commun"},{"issue":"06","key":"ref123","doi-asserted-by":"crossref","first-page":"e0123867","DOI":"10.1371\/journal.pone.0123867","article-title":"Chemokine transfer by liver sinusoidal endothelial cells contributes to the recruitment of CD4+ T cells into the murine liver","volume":"10","author":"K Neumann","year":"2015","journal-title":"PLoS One"},{"issue":"04","key":"ref124","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/hep.27921","article-title":"Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: an important role for CXCL1","volume":"62","author":"B Chang","year":"2015","journal-title":"Hepatology"},{"issue":"01","key":"ref125","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/ng.3167","article-title":"What are super-enhancers?","volume":"47","author":"S Pott","year":"2015","journal-title":"Nat Genet"},{"issue":"05","key":"ref126","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/sj.mn.7800204","article-title":"Early hepatic microvascular injury in response to acetaminophen toxicity","volume":"10","author":"Y Ito","year":"2003","journal-title":"Microcirculation"},{"issue":"12","key":"ref127","doi-asserted-by":"crossref","first-page":"e447","DOI":"10.1038\/cddis.2012.185","article-title":"TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner","volume":"3","author":"A Badmann","year":"2012","journal-title":"Cell Death Dis"},{"issue":"01","key":"ref128","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/hep.32787","article-title":"Combinatorial targeting of G-protein-coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug-induced liver injury","volume":"78","author":"M Biagioli","year":"2023","journal-title":"Hepatology"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.toxlet.2010.01.020","article-title":"Exacerbation of acetaminophen-induced disturbances of liver sinusoidal endothelial cells in the absence of Kupffer cells in mice","volume":"194","author":"M P Holt","year":"2010","journal-title":"Toxicol Lett"},{"issue":"06","key":"ref130","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.bcp.2013.07.006","article-title":"Role of hepatic resident and infiltrating macrophages in liver repair after acute injury","volume":"86","author":"Q You","year":"2013","journal-title":"Biochem Pharmacol"},{"issue":"04","key":"ref131","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.jhep.2017.05.020","article-title":"Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling","volume":"67","author":"T Teratani","year":"2017","journal-title":"J Hepatol"},{"issue":"04","key":"ref132","doi-asserted-by":"crossref","first-page":"221","DOI":"10.7555\/JBR.32.20180087","article-title":"Hepatic ischemia-reperfusion injury in liver transplant setting: mechanisms and protective strategies","volume":"33","author":"S Rampes","year":"2019","journal-title":"J Biomed Res"},{"issue":"02","key":"ref133","first-page":"268","article-title":"Ischemia\/Reperfusion injury in the aged liver: the importance of the sinusoidal endothelium in developing therapeutic strategies for the elderly","volume":"75","author":"D Hide","year":"2020","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref134","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s10353-015-0363-3","article-title":"Ischemia reperfusion-facilitated sinusoidal endothelial cell injury in liver transplantation and the resulting impact of extravasated platelet aggregation","volume":"48","author":"T Miyashita","year":"2016","journal-title":"Eur Surg"},{"issue":"03","key":"ref135","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/10715769209068166","article-title":"Platelet activating factor stimulates and primes the liver, Kupffer cells and neutrophils to release superoxide anion","volume":"17","author":"A P Bautista","year":"1992","journal-title":"Free Radic Res Commun"},{"issue":"01","key":"ref136","doi-asserted-by":"crossref","first-page":"G15","DOI":"10.1152\/ajpgi.00342.2002","article-title":"Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning","volume":"284","author":"H Jaeschke","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"02","key":"ref137","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1053\/jhep.2003.50069","article-title":"Effect of cold preservation on intracellular calcium concentration and calpain activity in rat sinusoidal endothelial cells","volume":"37","author":"G A Upadhya","year":"2003","journal-title":"Hepatology"},{"issue":"01","key":"ref138","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jhep.2016.07.051","article-title":"Cross-talk between autophagy and KLF2 determines endothelial cell phenotype and microvascular function in acute liver injury","volume":"66","author":"S Guix\u00e9-Muntet","year":"2017","journal-title":"J Hepatol"},{"issue":"03","key":"ref139","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jhep.2014.10.007","article-title":"Mouse hepatocytes and LSEC proteome reveal novel mechanisms of ischemia\/reperfusion damage and protection by A2aR stimulation","volume":"62","author":"G Mandili","year":"2015","journal-title":"J Hepatol"},{"issue":"03","key":"ref140","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/hep.24755","article-title":"Addition of simvastatin to cold storage solution prevents endothelial dysfunction in explanted rat livers","volume":"55","author":"L Russo","year":"2012","journal-title":"Hepatology"},{"issue":"01","key":"ref141","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s42003-023-04564-0","article-title":"Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model","volume":"6","author":"J Xin","year":"2023","journal-title":"Commun Biol"},{"key":"ref142","doi-asserted-by":"crossref","first-page":"108372","DOI":"10.1016\/j.pharmthera.2023.108372","article-title":"Endotheliopathy in the metabolic syndrome: mechanisms and clinical implications","volume":"244","author":"K Furuta","year":"2023","journal-title":"Pharmacol Ther"},{"issue":"16","key":"ref143","doi-asserted-by":"crossref","first-page":"8489","DOI":"10.3390\/ijms22168489","article-title":"Immunonano-lipocarrier-mediated liver sinusoidal endothelial cell-specific RUNX1 inhibition impedes immune cell infiltration and hepatic inflammation in murine model of NASH","volume":"22","author":"D M Tripathi","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"09","key":"ref144","doi-asserted-by":"crossref","first-page":"14029","DOI":"10.1021\/acsnano.2c03858","article-title":"Sequential nano-penetrators of capillarized liver sinusoids and extracellular matrix barriers for liver fibrosis therapy","volume":"16","author":"L F Zhang","year":"2022","journal-title":"ACS Nano"},{"issue":"09","key":"ref145","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1136\/gutjnl-2014-308338","article-title":"KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins","volume":"64","author":"G Marrone","year":"2015","journal-title":"Gut"},{"issue":"01","key":"ref146","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jhep.2012.08.026","article-title":"The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins","volume":"58","author":"G Marrone","year":"2013","journal-title":"J Hepatol"},{"issue":"03","key":"ref147","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/anie.202008625","article-title":"Selective N-terminal BET bromodomain inhibitors by targeting non-conserved residues and structured water displacement*","volume":"60","author":"H Cui","year":"2021","journal-title":"Angew Chem Int Ed Engl"},{"issue":"11","key":"ref148","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.2337\/db11-0255","article-title":"Endothelial NO\/cGMP\/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding","volume":"60","author":"S Tateya","year":"2011","journal-title":"Diabetes"},{"issue":"01","key":"ref149","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/s42003-021-02611-2","article-title":"Targeting integrin \u03b1v\u03b23 by a rationally designed protein for chronic liver disease treatment","volume":"4","author":"R C Turaga","year":"2021","journal-title":"Commun Biol"},{"issue":"04","key":"ref150","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.cell.2020.01.015","article-title":"Single-cell transcriptome atlas of murine endothelial cells","volume":"180","author":"J Kalucka","year":"2020","journal-title":"Cell"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41586-019-1373-2","article-title":"A human liver cell atlas reveals heterogeneity and epithelial progenitors","volume":"572","author":"N Aizarani","year":"2019","journal-title":"Nature"},{"key":"ref152","doi-asserted-by":"publisher","DOI":"10.1101\/2022.10.27.514070","article-title":"A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients","author":"Y Pita-Juarez","year":"2022","journal-title":"bioRxiv"},{"issue":"01","key":"ref153","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/hep4.1797","article-title":"Transcriptomic cross-species analysis of chronic liver disease reveals consistent regulation between humans and mice","volume":"6","author":"C H Holland","year":"2022","journal-title":"Hepatol Commun"},{"issue":"11","key":"ref154","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1038\/s42255-022-00674-x","article-title":"Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity","volume":"4","author":"O Bondareva","year":"2022","journal-title":"Nat Metab"},{"key":"ref155","doi-asserted-by":"crossref","first-page":"127","DOI":"10.48101\/ujms.v127.9051","article-title":"Toward a granular molecular-anatomic map of the blood vasculature - single-cell RNA sequencing makes the leap","volume":"127","author":"C Betsholtz","year":"2022","journal-title":"Ups J Med Sci"},{"key":"ref156","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41586-018-0590-4","article-title":"Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris","volume":"562","author":"C Tabula Muris","year":"2018","journal-title":"Nature"},{"issue":"19","key":"ref157","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1161\/CIRCULATIONAHA.119.041433","article-title":"Single-cell RNA sequencing unveils unique transcriptomic signatures of organ-specific endothelial cells","volume":"142","author":"D T Paik","year":"2020","journal-title":"Circulation"},{"issue":"12","key":"ref158","doi-asserted-by":"crossref","first-page":"e9682","DOI":"10.15252\/msb.20209682","article-title":"A single cell atlas of the human liver tumor microenvironment","volume":"16","author":"H Massalha","year":"2020","journal-title":"Mol Syst Biol"},{"issue":"04","key":"ref159","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1089\/omi.2019.0215","article-title":"A multi-omics approach to liver diseases: integration of single nuclei transcriptomics with proteomics and HiCap bulk data in human liver","volume":"24","author":"M Cavalli","year":"2020","journal-title":"OMICS"}],"container-title":["Seminars in Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2128-5907.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T19:31:55Z","timestamp":1698867115000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2128-5907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":159,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2023,11,1]]},"published-print":{"date-parts":[[2023,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2128-5907","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0272-8087","1098-8971"],"issn-type":[{"value":"0272-8087","type":"print"},{"value":"1098-8971","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,7,13]]},"published":{"date-parts":[[2023,7,13]]}}}