{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:22Z","timestamp":1787004862193,"version":"build-2736575974"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"crossref","award":["10882"],"award-info":[{"award-number":["10882"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background and study aims Fiducial markers have demonstrated clinical value in radiotherapy in several organs, but little is known about markers in the stomach. Here, we assess the technical feasibility of endoscopic placement of markers in gastric cancer patients and their potential benefit for image-guided radiotherapy (IGRT).<\/jats:p>\n                  <jats:p>Patients and methods In this prospective feasibility study, 14 gastric cancer patients underwent endoscopy-guided gold (all patients) and liquid (7 patients) marker placements distributed throughout the stomach. Technical feasibility, procedure duration, and potential complications were evaluated. Assessed benefit for IGRT comprised marker visibility on acquired imaging (3\u20134 computed tomography [CT] scans and 19\u201325 cone-beam CTs [CBCTs] per patient) and lack of migration. Marker visibility was compared per marker type and location (gastroesophageal junction (i.e., junction\/cardia), corpus (corpus\/antrum\/fundus), and pylorus).<\/jats:p>\n                  <jats:p>Results Of the 93 marker implantation attempts, 59 were\n      successful, i.e., marker in stomach wall and present during entire 5-week radiotherapy course\n      (2\u20136 successfully placed markers per patient), with no significant difference (Fisher\u2019s exact\n      test; P&gt;0.05) in success rate between gold (39\/66=59%) and\n      liquid (20\/27=74%). Average procedure duration was 24.4 min (range 16\u201338). No\n      procedure-related complications were reported. All successfully placed markers were visible on\n      all CTs, with 81% visible on \u226595% of CBCTs. Five markers were poorly visible (on &lt;75% of\n      CBCTs), possibly due to small marker volume and peristaltic motion since all five were liquid\n      markers located in the corpus. No migration was observed.<\/jats:p>\n                  <jats:p>Conclusions Endoscopic placement of fiducial markers in the stomach is technically feasible and safe. Being well visible and positionally stable, markers provide a potential benefit for IGRT.<\/jats:p>","DOI":"10.1055\/a-2129-2840","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T18:53:02Z","timestamp":1689274382000},"page":"E866-E872","source":"Crossref","is-referenced-by-count":3,"title":["Endoscopically placed fiducial markers for image-guided radiotherapy in preoperative gastric cancer: Technical feasibility and potential benefit"],"prefix":"10.1055","volume":"11","clinical-trial-number":[{"clinical-trial-number":"ntr7241","registry":"10.18810\/dutch-trial-register"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8438-5566","authenticated-orcid":false,"given":"Margot","family":"Bleeker","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands"},{"name":"Cancer treatment and quality of life, Imaging and biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5879-4494","authenticated-orcid":false,"given":"Astrid","family":"van der Horst","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands"},{"name":"Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"Bel","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands"},{"name":"Cancer treatment and quality of life, Imaging and biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Jakob","family":"Sonke","sequence":"additional","affiliation":[{"name":"Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4424-0079","authenticated-orcid":false,"given":"Jeanin E.","family":"van Hooft","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands"},{"name":"Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. E.","family":"Pouw","sequence":"additional","affiliation":[{"name":"Cancer treatment and quality of life, Imaging and biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands"},{"name":"Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten C.C.M.","family":"Hulshof","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1200\/JCO.2011.36.7136","article-title":"Updated analysis of SWOG-directed intergroup study 0116: A phase III trial of\n          adjuvant radiochemotherapy versus observation after curative gastric cancer\n          resection","volume":"30","author":"SR 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