{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:42:55Z","timestamp":1782308575394,"version":"3.54.5"},"reference-count":158,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"crossref","award":["R01 DK98414"],"award-info":[{"award-number":["R01 DK98414"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Liver Dis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>Exposure to hepatotoxic chemicals is involved in liver disease\u2013related morbidity and mortality worldwide. The liver responds to damage by triggering compensatory hepatic regeneration. Physical agent or chemical-induced liver damage disrupts hepatocyte proteostasis, including endoplasmic reticulum (ER) homeostasis. Post\u2013liver injury ER experiences a homeostatic imbalance, followed by active ER stress response signaling. Activated ER stress response causes selective upregulation of stress response genes and downregulation of many hepatocyte genes. Acetaminophen overdose, carbon tetrachloride, acute and chronic alcohol exposure, and physical injury activate the ER stress response, but details about the cellular consequences of the ER stress response on liver regeneration remain unclear. The current data indicate that inhibiting the ER stress response after partial hepatectomy\u2013induced liver damage promotes liver regeneration, whereas inhibiting the ER stress response after chemical-induced hepatotoxicity impairs liver regeneration. This review summarizes key findings and emphasizes the knowledge gaps in the role of ER stress in injury and regeneration.<\/jats:p>","DOI":"10.1055\/a-2129-8977","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T22:48:23Z","timestamp":1689374903000},"page":"279-292","source":"Crossref","is-referenced-by-count":7,"title":["The Role of Endoplasmic Reticulum Stress Response in Liver Regeneration"],"prefix":"10.1055","volume":"43","author":[{"given":"Kshitij","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udayan","family":"Apte","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"issue":"21","key":"ref1","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"E Trefts","year":"2017","journal-title":"Curr Biol"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF01656368","article-title":"Surgical anatomy and anatomical surgery of the liver","volume":"6","author":"H Bismuth","year":"1982","journal-title":"World J Surg"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1083\/jcb.72.2.441","article-title":"Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study","volume":"72","author":"A Blouin","year":"1977","journal-title":"J Cell Biol"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1083\/jcb.201903090","article-title":"The cell biology of the hepatocyte: a membrane trafficking machine","volume":"218","author":"R J Schulze","year":"2019","journal-title":"J Cell Biol"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.cld.2007.06.001","article-title":"Mechanisms of drug-induced liver disease","volume":"11","author":"B K Gunawan","year":"2007","journal-title":"Clin Liver Dis"},{"issue":"08","key":"ref6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2016.97","article-title":"Liver regeneration - mechanisms and models to clinical application","volume":"13","author":"S J Forbes","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1083\/jcb.201612111","article-title":"Shaping proteostasis at the cellular, tissue, and organismal level","volume":"216","author":"A J Sala","year":"2017","journal-title":"J Cell Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature17041","article-title":"Protein misfolding in the endoplasmic reticulum as a conduit to human disease","volume":"529","author":"M Wang","year":"2016","journal-title":"Nature"},{"issue":"07","key":"ref9","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"D Ron","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"P Walter","year":"2011","journal-title":"Science"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.tibs.2007.09.003","article-title":"That which does not kill me makes me stronger: adapting to chronic ER stress","volume":"32","author":"D T Rutkowski","year":"2007","journal-title":"Trends Biochem Sci"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0168-8278(05)80391-5","article-title":"Protein synthesis in regenerating rat liver during malnutrition","volume":"21","author":"S Skullman","year":"1994","journal-title":"J Hepatol"},{"issue":"05","key":"ref13","doi-asserted-by":"crossref","first-page":"e9156","DOI":"10.15252\/msb.20199156","article-title":"Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver","volume":"16","author":"V Dubois","year":"2020","journal-title":"Mol Syst Biol"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1053\/j.gastro.2016.12.040","article-title":"X-box binding protein 1 regulates unfolded protein, acute-phase, and DNA damage responses during regeneration of mouse liver","volume":"152","author":"J Argem\u00ed","year":"2017","journal-title":"Gastroenterology"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1055\/s-0039-1681032","article-title":"Endoplasmic reticulum stress in metabolic liver diseases and hepatic fibrosis","volume":"39","author":"J L Maiers","year":"2019","journal-title":"Semin Liver Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"951406","DOI":"10.3389\/fimmu.2022.951406","article-title":"Endoplasmic reticulum stress in innate immune cells - a significant contribution to non-alcoholic fatty liver disease","volume":"13","author":"L Zhou","year":"2022","journal-title":"Front Immunol"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s41419-022-05444-x","article-title":"Endoplasmic reticulum stress-mediated cell death in liver injury","volume":"13","author":"J Zhang","year":"2022","journal-title":"Cell Death Dis"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nrm2546","article-title":"One step at a time: endoplasmic reticulum-associated degradation","volume":"9","author":"S S Vembar","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrm1052","article-title":"Quality control in the endoplasmic reticulum","volume":"4","author":"L Ellgaard","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"04","key":"ref20","first-page":"1","article-title":"Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling","volume":"4","author":"M Carrara","year":"2015","journal-title":"eLife"},{"issue":"06","key":"ref21","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/35014014","article-title":"Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response","volume":"2","author":"A Bertolotti","year":"2000","journal-title":"Nat Cell Biol"},{"issue":"52","key":"ref22","doi-asserted-by":"crossref","first-page":"18773","DOI":"10.1073\/pnas.0509487102","article-title":"On the mechanism of sensing unfolded protein in the endoplasmic reticulum","volume":"102","author":"J J Credle","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-cellbio-101011-155826","article-title":"Structural basis of the unfolded protein response","volume":"28","author":"A Korennykh","year":"2012","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"03","key":"ref24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ncb0311-184","article-title":"Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress","volume":"13","author":"I Tabas","year":"2011","journal-title":"Nat Cell Biol"},{"issue":"03","key":"ref25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.devcel.2007.07.018","article-title":"Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1","volume":"13","author":"K Yamamoto","year":"2007","journal-title":"Dev Cell"},{"issue":"42","key":"ref26","doi-asserted-by":"crossref","first-page":"17775","DOI":"10.1073\/pnas.0910342106","article-title":"In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles","volume":"106","author":"A J Schindler","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1091\/mbc.10.11.3787","article-title":"Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress","volume":"10","author":"K Haze","year":"1999","journal-title":"Mol Biol Cell"},{"issue":"06","key":"ref28","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S1097-2765(00)00133-7","article-title":"ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs","volume":"6","author":"J Ye","year":"2000","journal-title":"Mol Cell"},{"issue":"20","key":"ref29","doi-asserted-by":"crossref","first-page":"11041","DOI":"10.1073\/pnas.96.20.11041","article-title":"A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood","volume":"96","author":"M S Brown","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.alcohol.2004.07.004","article-title":"Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins","volume":"34","author":"M You","year":"2004","journal-title":"Alcohol"},{"issue":"03","key":"ref31","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.devcel.2018.04.023","article-title":"The UPR activator ATF6 responds to proteotoxic and lipotoxic stress by distinct mechanisms","volume":"46","author":"A B Tam","year":"2018","journal-title":"Dev Cell"},{"issue":"01","key":"ref32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ygeno.2021.11.034","article-title":"A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver","volume":"114","author":"A Ramdas Nair","year":"2022","journal-title":"Genomics"},{"issue":"05","key":"ref33","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0168-8278(03)00029-1","article-title":"Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis","volume":"38","author":"M Shuda","year":"2003","journal-title":"J Hepatol"},{"issue":"06","key":"ref34","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0092-8674(93)90648-A","article-title":"Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase","volume":"73","author":"J S Cox","year":"1993","journal-title":"Cell"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1101\/gad.12.12.1812","article-title":"A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase\/endoribonuclease (Ire1p) in mammalian cells","volume":"12","author":"W Tirasophon","year":"1998","journal-title":"Genes Dev"},{"issue":"12","key":"ref36","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1002\/j.1460-2075.1996.tb00666.x","article-title":"Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus","volume":"15","author":"C E Shamu","year":"1996","journal-title":"EMBO J"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/415092a","article-title":"IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA","volume":"415","author":"M Calfon","year":"2002","journal-title":"Nature"},{"issue":"07","key":"ref38","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(01)00611-0","article-title":"XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor","volume":"107","author":"H Yoshida","year":"2001","journal-title":"Cell"},{"issue":"04","key":"ref39","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1083\/jcb.200508145","article-title":"pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response","volume":"172","author":"H Yoshida","year":"2006","journal-title":"J Cell Biol"},{"issue":"17","key":"ref40","doi-asserted-by":"crossref","first-page":"13935","DOI":"10.1074\/jbc.M010677200","article-title":"Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress","volume":"276","author":"T Yoneda","year":"2001","journal-title":"J Biol Chem"},{"issue":"03","key":"ref41","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cell.2009.07.017","article-title":"IRE1\u03b1 kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates","volume":"138","author":"D Han","year":"2009","journal-title":"Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1129631","article-title":"Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response","volume":"313","author":"J Hollien","year":"2006","journal-title":"Science"},{"issue":"03","key":"ref43","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.200903014","article-title":"Regulated Ire1-dependent decay of messenger RNAs in mammalian cells","volume":"186","author":"J Hollien","year":"2009","journal-title":"J Cell Biol"},{"issue":"04","key":"ref44","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1053\/j.gastro.2020.06.031","article-title":"IRE1A stimulates hepatocyte-derived extracellular vesicles that promote inflammation in mice with steatohepatitis","volume":"159","author":"D Dasgupta","year":"2020","journal-title":"Gastroenterology"},{"issue":"03","key":"ref45","doi-asserted-by":"crossref","first-page":"110258","DOI":"10.1016\/j.celrep.2021.110258","article-title":"A tango for coats and membranes: new insights into ER-to-Golgi traffic","volume":"38","author":"M Aridor","year":"2022","journal-title":"Cell Rep"},{"issue":"03","key":"ref46","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/hep.28921","article-title":"The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice","volume":"65","author":"J L Maiers","year":"2017","journal-title":"Hepatology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase","volume":"397","author":"H P Harding","year":"1999","journal-title":"Nature"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"eaat5314","DOI":"10.1126\/science.aat5314","article-title":"The integrated stress response: from mechanism to disease","volume":"368","author":"M Costa-Mattioli","year":"2020","journal-title":"Science"},{"issue":"04","key":"ref49","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","article-title":"Roles of CHOP\/GADD153 in endoplasmic reticulum stress","volume":"11","author":"S Oyadomari","year":"2004","journal-title":"Cell Death Differ"},{"issue":"05","key":"ref50","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"H P Harding","year":"2000","journal-title":"Mol Cell"},{"issue":"05","key":"ref51","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1083\/jcb.153.5.1011","article-title":"Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2\u03b1","volume":"153","author":"I Novoa","year":"2001","journal-title":"J Cell Biol"},{"issue":"04","key":"ref52","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1083\/jcb.200308075","article-title":"Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells","volume":"163","author":"C Jousse","year":"2003","journal-title":"J Cell Biol"},{"issue":"13","key":"ref53","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1074\/jbc.M110.216093","article-title":"Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation","volume":"286","author":"L R Palam","year":"2011","journal-title":"J Biol Chem"},{"issue":"02","key":"ref54","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41573-021-00320-3","article-title":"Pharmacological targeting of endoplasmic reticulum stress in disease","volume":"21","author":"S J Marciniak","year":"2022","journal-title":"Nat Rev Drug Discov"},{"issue":"12","key":"ref55","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/s41419-020-03264-5","article-title":"Phosphorylation of eIF2\u03b1 signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner","volume":"11","author":"J Li","year":"2020","journal-title":"Cell Death Dis"},{"issue":"04","key":"ref56","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jhep.2020.04.038","article-title":"ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development","volume":"73","author":"Q Song","year":"2020","journal-title":"J Hepatol"},{"issue":"22","key":"ref57","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1091\/mbc.e11-06-0510","article-title":"The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress","volume":"22","author":"B F Teske","year":"2011","journal-title":"Mol Biol Cell"},{"issue":"01","key":"ref58","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1038\/s41598-019-38705-5","article-title":"Widespread PERK-dependent repression of ER targets in response to ER stress","volume":"9","author":"N Gonen","year":"2019","journal-title":"Sci Rep"},{"issue":"09","key":"ref59","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/cdd.2014.241","article-title":"Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1\/XBP1 and PERK\/ATF4 signalling rather than a switch between signalling branches determine cell survival","volume":"22","author":"F Walter","year":"2015","journal-title":"Cell Death Differ"},{"issue":"47","key":"ref60","doi-asserted-by":"crossref","first-page":"18270","DOI":"10.1074\/jbc.RA118.002121","article-title":"ER stress signaling has an activating transcription factor 6\u03b1 (ATF6)-dependent \u201coff-switch\u201d","volume":"293","author":"F Walter","year":"2018","journal-title":"J Biol Chem"},{"issue":"04","key":"ref61","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0165-6147(98)01184-5","article-title":"A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases","volume":"19","author":"M Treiman","year":"1998","journal-title":"Trends Pharmacol Sci"},{"issue":"21","key":"ref62","doi-asserted-by":"crossref","first-page":"7431","DOI":"10.1016\/S0021-9258(17)40981-1","article-title":"Tunicamycin inhibits GlcNAc-lipid formation in plants","volume":"252","author":"M C Ericson","year":"1977","journal-title":"J Biol Chem"},{"issue":"11","key":"ref63","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1021\/bi00578a008","article-title":"Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichyl-phosphate Glc-NAc-1-phosphate transferase","volume":"18","author":"A Heifetz","year":"1979","journal-title":"Biochemistry"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-4939-1154-7_3","article-title":"Synthesis, processing, and function of N-glycans in N-glycoproteins","volume":"9","author":"E Bieberich","year":"2014","journal-title":"Adv Neurobiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/B978-0-12-385114-7.00004-0","article-title":"Measuring ER stress and the unfolded protein response using mammalian tissue culture system","volume":"490","author":"C M Oslowski","year":"2011","journal-title":"Methods Enzymol"},{"issue":"01","key":"ref66","doi-asserted-by":"crossref","first-page":"e00211","DOI":"10.1002\/prp2.211","article-title":"Role of endoplasmic reticulum stress in drug-induced toxicity","volume":"4","author":"F Foufelle","year":"2016","journal-title":"Pharmacol Res Perspect"},{"issue":"01","key":"ref67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22010004","article-title":"Thapsigargin\u2014from traditional medicine to anticancer drug","volume":"22","author":"A Jaskulska","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"04","key":"ref68","first-page":"4137","article-title":"Tunicamycin suppresses breast cancer cell growth and metastasis via regulation of the protein kinase B\/nuclear factor-\u03baB signaling pathway","volume":"15","author":"X Wang","year":"2018","journal-title":"Oncol Lett"},{"issue":"03","key":"ref69","first-page":"4203","article-title":"Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT\/mTOR signaling pathway","volume":"17","author":"S You","year":"2018","journal-title":"Mol Med Rep"},{"issue":"10","key":"ref70","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.3390\/v12101093","article-title":"Thapsigargin at non-cytotoxic levels induces a potent host antiviral response that blocks influenza a virus replication","volume":"12","author":"L V Goulding","year":"2020","journal-title":"Viruses"},{"issue":"04","key":"ref71","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ajpath.2018.12.006","article-title":"Liver regeneration after acetaminophen hepatotoxicity: mechanisms and therapeutic opportunities","volume":"189","author":"B Bhushan","year":"2019","journal-title":"Am J Pathol"},{"issue":"01","key":"ref72","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/toxsci\/kfi336","article-title":"Intracellular signaling mechanisms of acetaminophen-induced liver cell death","volume":"89","author":"H Jaeschke","year":"2006","journal-title":"Toxicol Sci"},{"issue":"01","key":"ref73","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/toxsci\/kfl077","article-title":"Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury","volume":"94","author":"M L Bajt","year":"2006","journal-title":"Toxicol Sci"},{"issue":"01","key":"ref74","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/10590501.2014.881648","article-title":"Endoplasmic reticulum stress in drug- and environmental toxicant-induced liver toxicity","volume":"32","author":"S Chen","year":"2014","journal-title":"J Environ Sci Health Part C Environ Carcinog Ecotoxicol Rev"},{"issue":"02","key":"ref75","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1084\/jem.20111298","article-title":"IRE1\u03b1 activation protects mice against acetaminophen-induced hepatotoxicity","volume":"209","author":"K Y Hur","year":"2012","journal-title":"J Exp Med"},{"issue":"03","key":"ref76","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jhep.2013.04.024","article-title":"CHOP is a critical regulator of acetaminophen-induced hepatotoxicity","volume":"59","author":"D Uzi","year":"2013","journal-title":"J Hepatol"},{"issue":"03","key":"ref77","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0006-2952(90)90558-3","article-title":"Immunochemical quantitation of 3-(cysteine-S-yl)acetaminophen protein adducts in subcellular liver fractions following a hepatotoxic dose of acetaminophen","volume":"40","author":"N R Pumford","year":"1990","journal-title":"Biochem Pharmacol"},{"issue":"07","key":"ref78","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/0006-2952(92)90207-Y","article-title":"N-acetyl-p-benzoquinone imine-induced protein thiol modification in isolated rat hepatocytes","volume":"43","author":"M Weis","year":"1992","journal-title":"Biochem Pharmacol"},{"issue":"07","key":"ref79","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1021\/tx960069d","article-title":"The covalent binding of [14C]acetaminophen to mouse hepatic microsomal proteins: the specific binding to calreticulin and the two forms of the thiol:protein disulfide oxidoreductases","volume":"9","author":"L Zhou","year":"1996","journal-title":"Chem Res Toxicol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0300-483X(97)03617-2","article-title":"Tissue injury and repair as parallel and opposing responses to CCl4 hepatotoxicity: a novel dose-response","volume":"118","author":"P S Rao","year":"1997","journal-title":"Toxicology"},{"issue":"03","key":"ref81","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"J P Iredale","year":"2007","journal-title":"J Clin Invest"},{"issue":"52","key":"ref82","doi-asserted-by":"crossref","first-page":"26794","DOI":"10.1074\/jbc.M116.736991","article-title":"Endoplasmic reticulum stress-induced hepatocellular death pathways mediate liver injury and fibrosis via stimulator of interferon genes","volume":"291","author":"A Iracheta-Vellve","year":"2016","journal-title":"J Biol Chem"},{"issue":"37","key":"ref83","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.3748\/wjg.v13.i37.4974","article-title":"Alcohol-induced steatosis in liver cells","volume":"13","author":"T M Donohue Jr","year":"2007","journal-title":"World J Gastroenterol"},{"issue":"06","key":"ref84","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0168-8278(97)80144-4","article-title":"CYP2E1 activity in patients with alcoholic liver disease","volume":"27","author":"K Dilger","year":"1997","journal-title":"J Hepatol"},{"issue":"01","key":"ref85","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0006-2952(92)90042-H","article-title":"Ethanol metabolism in rat brain homogenates by a catalase-H2O2 system","volume":"44","author":"C MG Aragon","year":"1992","journal-title":"Biochem Pharmacol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fphys.2012.00193","article-title":"Acute alcohol-induced liver injury","volume":"3","author":"V L Massey","year":"2012","journal-title":"Front Physiol"},{"issue":"S 03","key":"ref87","first-page":"S56","article-title":"Alcohol and lipid metabolism","volume":"21","author":"D W Crabb","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"issue":"08","key":"ref88","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nrc2191","article-title":"Molecular mechanisms of alcohol-mediated carcinogenesis","volume":"7","author":"H K Seitz","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"ref89","first-page":"271","article-title":"The chemistry of acetaldehyde-protein adducts","volume":"1","author":"D J Tuma","year":"1991","journal-title":"Alcohol Alcohol Suppl"},{"issue":"28","key":"ref90","first-page":"3462","article-title":"Alcoholic liver disease and hepatitis C: a frequently underestimated combination","volume":"15","author":"S Mueller","year":"2009","journal-title":"World J Gastroenterol"},{"issue":"02","key":"ref91","first-page":"51","article-title":"Role of genetic factors in alcoholic liver disease","volume":"7","author":"Y Yuan","year":"2019","journal-title":"J Transl Int Med"},{"issue":"01","key":"ref92","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.gastro.2014.10.042","article-title":"Gut-liver axis in alcoholic liver disease","volume":"148","author":"G Szabo","year":"2015","journal-title":"Gastroenterology"},{"issue":"01","key":"ref93","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/hep.23258","article-title":"Alcoholic liver disease","volume":"51","author":"R S O'Shea","year":"2010","journal-title":"Hepatology"},{"issue":"04","key":"ref94","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1055\/s-0028-1091981","article-title":"Mechanisms of disease progression in nonalcoholic fatty liver disease","volume":"28","author":"J Jou","year":"2008","journal-title":"Semin Liver Dis"},{"issue":"08","key":"ref95","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1096\/fj.00-0650rev","article-title":"Current concepts in the pathogenesis of alcoholic liver injury","volume":"15","author":"H Tsukamoto","year":"2001","journal-title":"FASEB J"},{"issue":"02","key":"ref96","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"R Bataller","year":"2005","journal-title":"J Clin Invest"},{"issue":"02","key":"ref97","first-page":"147","article-title":"Alcoholic liver disease: pathogenesis and current management","volume":"38","author":"N A Osna","year":"2017","journal-title":"Alcohol Res"},{"issue":"04","key":"ref98","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2010.11.005","article-title":"Endoplasmic reticulum stress in liver disease","volume":"54","author":"H Malhi","year":"2011","journal-title":"J Hepatol"},{"issue":"02","key":"ref99","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/febs.14389","article-title":"Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response","volume":"286","author":"D T Rutkowski","year":"2019","journal-title":"FEBS J"},{"issue":"05","key":"ref100","first-page":"1213","article-title":"Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease","volume":"6","author":"O Tsedensodnom","year":"2013","journal-title":"Dis Model Mech"},{"key":"ref101","first-page":"216450","article-title":"Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuries","author":"C Ji","year":"2012","journal-title":"Biochem Res Int"},{"issue":"03","key":"ref102","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S1386-6346(00)00112-1","article-title":"Chronic alcohol exposure of rats exacerbates apoptosis in hepatocytes and sinusoidal endothelial cells","volume":"19","author":"I V Deaciuc","year":"2001","journal-title":"Hepatol Res"},{"issue":"08","key":"ref103","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1097\/01.alc.0000174691.03751.11","article-title":"Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding","volume":"29","author":"C Ji","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"issue":"04","key":"ref104","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.jhep.2010.07.023","article-title":"ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes","volume":"54","author":"L Magne","year":"2011","journal-title":"J Hepatol"},{"issue":"06","key":"ref105","doi-asserted-by":"crossref","first-page":"e1491","DOI":"10.1002\/wrna.1491","article-title":"Regulation of translation initiation factor eIF2B at the hub of the integrated stress response","volume":"9","author":"G D Pavitt","year":"2018","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/9781119436812.ch45","article-title":"Liver regeneration","volume":"12","author":"G K Michalopoulos","year":"2020","journal-title":"Liver Biol Pathobiol."},{"issue":"01","key":"ref107","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver regeneration: biological and pathological mechanisms and implications","volume":"18","author":"G K Michalopoulos","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2019.03.001","volume-title":"Mechanisms and Biomarkers of Liver Regeneration after Drug-Induced Liver Injury. Vol 85","author":"M M Clemens","year":"2019","edition":"1st ed."},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-801238-3.64918-8","volume-title":"Hepatic Defenses against Toxicity: Liver Regeneration and Tissue Repair. Vol 9","author":"U Apte","year":"2018","edition":"3rd ed."},{"issue":"03","key":"ref110","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.jhep.2014.10.022","article-title":"Role for the endoplasmic reticulum stress sensor IRE1\u03b1 in liver regenerative responses","volume":"62","author":"Y Liu","year":"2015","journal-title":"J Hepatol"},{"issue":"05","key":"ref111","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1002\/hep.1840210531","article-title":"Rapid activation of the Stat3 transcription complex in liver regeneration","volume":"21","author":"D E Cressman","year":"1995","journal-title":"Hepatology"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"103213","DOI":"10.1016\/j.ebiom.2021.103213","article-title":"Interleukin-24 protects against liver injury in mouse models","volume":"64","author":"H H Wang","year":"2021","journal-title":"EBioMedicine"},{"issue":"01","key":"ref113","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41419-019-2209-6","article-title":"Intracellular XBP1-IL-24 axis dismantles cytotoxic unfolded protein response in the liver","volume":"11","author":"J Wang","year":"2020","journal-title":"Cell Death Dis"},{"key":"ref114","first-page":"186","article-title":"Experimental pathology of the liver: restoration of the liver of the white rat following partial surgical removal","volume":"12","author":"G M Higgins","year":"1931","journal-title":"Arch Pathol (Chic)"},{"issue":"05","key":"ref115","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/hep.1840080505","article-title":"Transplantation of microcarrier-attached hepatocytes into 90% partially hepatectomized rats","volume":"8","author":"A A Demetriou","year":"1988","journal-title":"Hepatology"},{"issue":"08","key":"ref116","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1097\/00000478-200608000-00009","article-title":"Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome","volume":"30","author":"A J Demetris","year":"2006","journal-title":"Am J Surg Pathol"},{"issue":"06","key":"ref117","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/0016-5085(87)90274-5","article-title":"Rapid growth of an intact human liver transplanted into a recipient larger than the donor","volume":"93","author":"D H Van Thiel","year":"1987","journal-title":"Gastroenterology"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/0140-6736(92)90867-3","article-title":"Liver regeneration in recipients and donors after transplantation","volume":"339","author":"S Kawasaki","year":"1992","journal-title":"Lancet"},{"issue":"02","key":"ref119","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/hep.1840070225","article-title":"Evidence that host size determines liver size: studies in dogs receiving orthotopic liver transplants","volume":"7","author":"I Kam","year":"1987","journal-title":"Hepatology"},{"issue":"01","key":"ref120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2353\/ajpath.2010.090675","article-title":"Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas","volume":"176","author":"G K Michalopoulos","year":"2010","journal-title":"Am J Pathol"},{"key":"ref121","first-page":"101","article-title":"Liver regeneration","volume":"93","author":"G K Michalopoulos","year":"2005","journal-title":"Adv Biochem Eng Biotechnol"},{"issue":"03","key":"ref122","first-page":"736","article-title":"Liver regeneration","volume":"211","author":"MICHALOPOULOS GK","year":"2007","journal-title":"J Cell Physiol"},{"issue":"01","key":"ref123","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.stem.2019.11.001","article-title":"Broad distribution of hepatocyte proliferation in liver homeostasis and regeneration","volume":"26","author":"F Chen","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"01","key":"ref124","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/cphy.c120014","article-title":"Principles of liver regeneration and growth homeostasis","volume":"3","author":"G K Michalopoulos","year":"2013","journal-title":"Compr Physiol"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature23015","article-title":"Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration","volume":"547","author":"A Raven","year":"2017","journal-title":"Nature"},{"issue":"08","key":"ref126","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ncb3203","article-title":"Hepatic progenitor cells of biliary origin with liver repopulation capacity","volume":"17","author":"W Y Lu","year":"2015","journal-title":"Nat Cell Biol"},{"issue":"03","key":"ref127","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1053\/j.gastro.2013.10.019","article-title":"Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish","volume":"146","author":"T Y Choi","year":"2014","journal-title":"Gastroenterology"},{"issue":"01","key":"ref128","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.stem.2018.05.022","article-title":"Chronic liver injury induces conversion of biliary epithelial cells into hepatocytes","volume":"23","author":"X Deng","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"e15034","DOI":"10.7554\/eLife.15034","article-title":"Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling","volume":"5","author":"K Kamimoto","year":"2016","journal-title":"eLife"},{"issue":"03","key":"ref130","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1053\/jhep.2002.35441","article-title":"Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation","volume":"36","author":"Q Xie","year":"2002","journal-title":"Hepatology"},{"issue":"09","key":"ref131","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1097\/00007890-200105150-00015","article-title":"Protective role of tauroursodeoxycholate during harvesting and cold storage of human liver: a pilot study in transplant recipients","volume":"71","author":"L Falasca","year":"2001","journal-title":"Transplantation"},{"issue":"02","key":"ref132","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.surg.2005.04.019","article-title":"Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis","volume":"138","author":"M Vilatoba","year":"2005","journal-title":"Surgery"},{"issue":"07","key":"ref133","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1038\/cddis.2010.29","article-title":"Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion","volume":"1","author":"I Ben Mosbah","year":"2010","journal-title":"Cell Death Dis"},{"issue":"03","key":"ref134","doi-asserted-by":"crossref","first-page":"e1107","DOI":"10.1038\/cddis.2014.65","article-title":"Intermittent selective clamping improves rat liver regeneration by attenuating oxidative and endoplasmic reticulum stress","volume":"5","author":"I Ben Mosbah","year":"2014","journal-title":"Cell Death Dis"},{"key":"ref135","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.biocel.2015.01.015","article-title":"The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis","volume":"61","author":"P S Kolb","year":"2015","journal-title":"Int J Biochem Cell Biol"},{"issue":"03","key":"ref136","doi-asserted-by":"crossref","first-page":"58","DOI":"10.7453\/gahmj.2014.017","article-title":"The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseases","volume":"3","author":"S Vang","year":"2014","journal-title":"Glob Adv Health Med"},{"issue":"02","key":"ref137","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3892\/ijmm.2012.1213","article-title":"Co-administration of prostaglandin E1 with somatostatin attenuates acute liver damage after massive hepatectomy in rats via inhibition of inflammatory responses, apoptosis and endoplasmic reticulum stress","volume":"31","author":"C Jia","year":"2013","journal-title":"Int J Mol Med"},{"issue":"12","key":"ref138","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.tcb.2019.09.005","article-title":"The UFMylation system in proteostasis and beyond","volume":"29","author":"Y Gerakis","year":"2019","journal-title":"Trends Cell Biol"},{"issue":"03","key":"ref139","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.gpb.2016.04.001","article-title":"UFMylation: a unique & fashionable modification for life","volume":"14","author":"Y Wei","year":"2016","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"ref140","doi-asserted-by":"crossref","first-page":"760429","DOI":"10.3389\/fonc.2021.760429","article-title":"Cyclin-dependent kinase 5 regulatory subunit associated protein 3: potential functions and implications for development and disease","volume":"11","author":"L Sheng","year":"2021","journal-title":"Front Oncol"},{"issue":"12","key":"ref141","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/j.ajpath.2020.08.011","article-title":"CDK5RAP3 deficiency restrains liver regeneration after partial hepatectomy triggering endoplasmic reticulum stress","volume":"190","author":"S Yang","year":"2020","journal-title":"Am J Pathol"},{"issue":"24","key":"ref142","first-page":"1","article-title":"ER stress induces cell cycle arrest at the g2\/m phase through eIF2\u03b1 phosphorylation and GADD45\u03b1","volume":"20","author":"D Lee","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"12","key":"ref143","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1091\/mbc.e05-03-0268","article-title":"PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway","volume":"16","author":"R B Hamanaka","year":"2005","journal-title":"Mol Biol Cell"},{"issue":"37","key":"ref144","doi-asserted-by":"crossref","first-page":"9900","DOI":"10.1073\/pnas.1701757114","article-title":"ER stress and distinct outputs of the IRE1\u03b1 RNase control proliferation and senescence in response to oncogenic Ras","volume":"114","author":"N Blazanin","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"ref145","doi-asserted-by":"crossref","first-page":"9392","DOI":"10.1128\/MCB.25.21.9392-9405.2005","article-title":"Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta","volume":"25","author":"O Pluquet","year":"2005","journal-title":"Mol Cell Biol"},{"issue":"10","key":"ref146","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nsmb.3458","article-title":"CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response","volume":"24","author":"F Hong","year":"2017","journal-title":"Nat Struct Mol Biol"},{"issue":"06","key":"ref147","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/hep.32318","article-title":"Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response-dependent destabilization of tumor protein P53","volume":"76","author":"F Hong","year":"2022","journal-title":"Hepatology"},{"issue":"12","key":"ref148","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1172\/JCI62973","article-title":"ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth","volume":"122","author":"L S Hart","year":"2012","journal-title":"J Clin Invest"},{"issue":"10","key":"ref149","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/ncb1471","article-title":"Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway","volume":"8","author":"C Denoyelle","year":"2006","journal-title":"Nat Cell Biol"},{"issue":"12","key":"ref150","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.tibs.2016.09.001","article-title":"Calcium at the center of cell signaling: interplay between endoplasmic reticulum, mitochondria, and lysosomes","volume":"41","author":"A Raffaello","year":"2016","journal-title":"Trends Biochem Sci"},{"issue":"04","key":"ref151","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.bbalip.2013.11.014","article-title":"MAM (mitochondria-associated membranes) in mammalian cells: lipids and beyond","volume":"1841","author":"J E Vance","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"03","key":"ref152","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41419-017-0033-4","article-title":"Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages","volume":"9","author":"E D Yoboue","year":"2018","journal-title":"Cell Death Dis"},{"key":"ref153","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ceca.2017.05.003","article-title":"Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death","volume":"69","author":"S Marchi","year":"2018","journal-title":"Cell Calcium"},{"issue":"09","key":"ref154","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.3390\/cells8091071","article-title":"Mechanistic connections between endoplasmic reticulum (ER) redox control and mitochondrial metabolism","volume":"8","author":"Y Fan","year":"2019","journal-title":"Cells"},{"issue":"10","key":"ref155","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.tem.2014.06.007","article-title":"Stress-responsive regulation of mitochondria through the ER unfolded protein response","volume":"25","author":"T K Rainbolt","year":"2014","journal-title":"Trends Endocrinol Metab"},{"key":"ref156","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ceca.2017.05.015","article-title":"Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death","volume":"70","author":"T Guti\u00e9rrez","year":"2018","journal-title":"Cell Calcium"},{"issue":"05","key":"ref157","doi-asserted-by":"publisher","first-page":"101116","DOI":"10.1016\/j.isci.2020.101116","article-title":"NADPH and glutathione redox link TCA cycle activity to endoplasmic reticulum homeostasis","volume":"23","author":"E R Gansemer","year":"2020","journal-title":"iScience"},{"key":"ref158","first-page":"1","article-title":"Endoplasmic reticulum stress in liver diseases","author":"A Ajoolabady","year":"2022","journal-title":"Hepatology"}],"container-title":["Seminars in Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2129-8977.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T23:35:39Z","timestamp":1698881739000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2129-8977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,14]]},"references-count":158,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2023,11,1]]},"published-print":{"date-parts":[[2023,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2129-8977","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0272-8087","1098-8971"],"issn-type":[{"value":"0272-8087","type":"print"},{"value":"1098-8971","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,7,14]]},"published":{"date-parts":[[2023,7,14]]}}}