{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:04:48Z","timestamp":1759449888801,"version":"build-2065373602"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromatic pupillometry allows quantification of photoreceptor-driven (extrinsic) and melanopsin-driven (intrinsic) responses of the intrinsic-photosensitive retinal ganglion cells (ipRGCs). This small subpopulation of retinal ganglion cells is also affected by glaucoma, making chromatic pupillometry a potential diagnostic tool. Studies show reduced phasic and tonic responses in glaucoma patients. The diagnostic value in earlier studies depended on the technical details and the study design. The purpose of this article is to give an introduction into the principles of chromatic pupillometry and to discuss the potential applications in the management of glaucoma.<\/jats:p>","DOI":"10.1055\/a-2130-0546","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T19:08:26Z","timestamp":1694113706000},"page":"1350-1358","source":"Crossref","is-referenced-by-count":0,"title":["Chromatic Pupillometry \u2013 a New Technique for Assessing Function in Glaucoma?"],"prefix":"10.1055","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0408-8981","authenticated-orcid":false,"given":"Cord","family":"Huchzermeyer","sequence":"additional","affiliation":[{"name":"Augenklinik mit Poliklinik, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/j.1442-9071.2012.02773.x","article-title":"Definition of glaucoma: clinical and experimental concepts","volume":"40","author":"R J Casson","year":"2012","journal-title":"Clin Experiment Ophthalmol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1016\/j.ophtha.2017.04.009","article-title":"Will Perimetry Be Performed to Monitor Glaucoma in 2025?","volume":"124 (12S)","author":"A S Camp","year":"2017","journal-title":"Ophthalmology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.preteyeres.2007.08.001","article-title":"A framework for comparing structural and functional measures of glaucomatous damage","volume":"26","author":"D C Hood","year":"2007","journal-title":"Prog Retin Eye Res"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055\/a-1351-9080","article-title":"[Value of Perimetric Measurements for Glaucoma Detection]","author":"R L\u00e4mmer","year":"2021","journal-title":"Klin Monbl Augenheilkd"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.preteyeres.2018.04.001","article-title":"The coma in glaucoma: Retinal ganglion cell dysfunction and recovery","volume":"65","author":"L E Fry","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10633-012-9353-y","article-title":"ISCEV standard for clinical pattern electroretinography (PERG): 2012 update","volume":"126","author":"M Bach","year":"2013","journal-title":"Doc Ophthalmol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s10633-018-9638-x","article-title":"ISCEV extended protocol for the photopic negative response (PhNR) of the full-field electroretinogram","volume":"136","author":"L Frishman","year":"2018","journal-title":"Doc Ophthalmol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1146\/annurev.neuro.23.1.743","article-title":"Parallel pathways for spectral coding in primate retina","volume":"23","author":"D M Dacey","year":"2000","journal-title":"Annu Rev Neurosci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"661938","DOI":"10.3389\/fneur.2021.661938","article-title":"Retinal Ganglion Cells \u2013 Diversity of Cell Types and Clinical Relevance","volume":"12","author":"U S Kim","year":"2021","journal-title":"Front Neurol"},{"volume-title":"The First Steps in Seeing","year":"1998","author":"R W Rodiek","key":"ref10"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1167\/7.14.1","article-title":"The temporal properties of the response of macaque ganglion cells and central mechanisms of flicker detection","author":"B B Lee","year":"2007","journal-title":"J Vis"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S1350-9462(00)00001-X","article-title":"Short-wavelength automated perimetry: it\u02bcs role in the clinic and for understanding ganglion cell function","volume":"19","author":"P A Sample","year":"2000","journal-title":"Prog Retin Eye Res"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/s0896-1549(03)00011-7","article-title":"Frequency-doubling technology perimetry","volume":"16","author":"A J Anderson","year":"2003","journal-title":"Ophthalmol Clin North Am"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1016\/S0042-6989(02)00102-5","article-title":"New, sensitive window on abnormal spatial vision: rarebit probing","volume":"42","author":"L Fris\u00e9n","year":"2002","journal-title":"Vision Res"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF01203566","article-title":"High-pass resolution perimetry. 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