{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:44Z","timestamp":1740126884858,"version":"3.37.3"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective To evaluate the impact of increased Activated Protein C (APC)\n                    resistance, decreased antithrombin III activity and hypocomplementemia on the\n                    pregnancy outcomes of the patients with methylentetrahydrofolate reductase\n                    (MTHFR) polymorphisms.<\/jats:p><jats:p>\n          Methods This study was composed of 83 pregnancies with MTHFR\n                    polymorphisms. Increased APC resistance, decreased antithrombin III activity and\n                    hypocomplementemia were accepted as risk factors for poor gestational\n                    outcome.<\/jats:p><jats:p>\n          Results Having at least one risk factor resulted in significantly higher\n                    rates of \u201cAPGAR score of&lt;7\u201d at the first ten minutes\n                    (p=0.009). Composite adverse outcome rate was also higher in patients\n                    with at least one of the defined risk factors despite lack of statistical\n                    significance (p=0.241). Rate of newborn with an \u201cAPGAR score\n                    of&lt;7\u201d at first ten minutes was significantly higher at patients\n                    with hypocomplementemia (p=0.03).<\/jats:p><jats:p>\n          Conclusion Hypocomplementemia is a risk factor for poor gestational\n                    outcome in pregnancies with MTHFR polymorphisms.<\/jats:p>","DOI":"10.1055\/a-2134-6452","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T22:54:11Z","timestamp":1692053651000},"page":"434-440","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Increased Activated Protein-C Resistance, Decreased\n                    Antithrombin III Activity and Hypocomplementemia on the Gestational Outcomes of\n                    Pregnancies with MTHFR Polymorphisms"],"prefix":"10.1055","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7953-2517","authenticated-orcid":false,"given":"Erdem","family":"Fadiloglu","sequence":"additional","affiliation":[{"name":"Division of Perinatal Medicine, Department of Obstetrics and\n                    Gynecology, Hacettepe University, Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanife Guler","family":"Donmez","sequence":"additional","affiliation":[{"name":"Department of Biology, Hacettepe University Faculty of Science, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemal","family":"Beksac","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Dr. Abdurrahman Yurtaslan Onkoloji\n                    Egitim ve Arastirma Hastanesi, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Sinan","family":"Beksac","sequence":"additional","affiliation":[{"name":"Division of Perinatal Medicine, Department of Obstetrics and\n                    Gynecology, Hacettepe University, Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"293867","DOI":"10.1155\/2012\/293867","article-title":"Both acute and chronic placental inflammation are overrepresented in term\n                    stillbirths: a case-control study","volume":"2012","author":"I Hulth\u00e9n Varli","year":"2012","journal-title":"Infect Dis Obstet Gynecol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s11906-013-0395-7","article-title":"Placental disease and the maternal syndrome of preeclampsia: missing links?","volume":"15","author":"D Tannetta","year":"2013","journal-title":"Curr Hypertens 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Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3233\/HAB-200401","article-title":"Effect of hypocomplementemia on perinatal outcomes of pregnancies with\n                    autoimmune disorders","volume":"28","author":"E Fadiloglu","year":"2020","journal-title":"Hum Antibodies"},{"key":"ref37","first-page":"129","article-title":"Increasing maternal body mass index is associated with systemic inflammation in\n                    the mother and the activation of distinct placental inflammatory pathways","volume":"90","author":"I L Aye","year":"2014","journal-title":"Biol Reprod"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2134-6452.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T23:47:29Z","timestamp":1701215249000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2134-6452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,14]]},"references-count":37,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2023,11,28]]},"published-print":{"date-parts":[[2023,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2134-6452","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"type":"print","value":"0948-2393"},{"type":"electronic","value":"1439-1651"}],"subject":[],"published":{"date-parts":[[2023,8,14]]}}}