{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:13:40Z","timestamp":1777583620527,"version":"3.51.4"},"reference-count":48,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund Die geltende Leitlinie f\u00fcr kinderonkologische\n                    Patienten mit febriler Granulozytopenie (FN) von 2016 empfiehlt eine\n                    Time-to-Antibiotics (TTA)&lt;60\u2009min.<\/jats:p><jats:p>\n          Methode Kritische Analyse verf\u00fcgbarer Studien und Metaanalysen,\n                    Diskussion der Konsequenzen in der Arbeitsgruppe Fieber bei Granulozytopenie der\n                    Fachgesellschaften f\u00fcr p\u00e4diatrische Onkologie und\n                    H\u00e4matologie und p\u00e4diatrische Infektiologie.<\/jats:p><jats:p>\n          Ergebnisse Die verf\u00fcgbaren Studien k\u00f6nnen keinen klinisch\n                    signifikanten Vorteil einer TTA&lt;60\u2009min f\u00fcr alle\n                    kinderonkologischen Patienten mit FN darstellen. Studien, die einen solchen\n                    Zusammenhang nahelegen, sind mit einem Triage Bias und anderen methodischen\n                    Limitationen behaftet und nutzen unterschiedliche TTA Definitionen. Hingegen ist\n                    eine TTA&lt;60\u2009min elementarer Bestandteil des\n                    Einstunden-Ma\u00dfnahme-B\u00fcndels bei septischem Schock oder Sepsis\n                    mit Organdysfunktion.<\/jats:p><jats:p>\n          Zusammenfassung Wenn alle kinderonkologischen Patienten mit neu\n                    aufgetretenem Fieber zeitnah durch gut ausgebildetes und trainiertes\n                    Fachpersonal eine strukturierte Anamnese und k\u00f6rperliche Untersuchung\n                    (inkl. Vitalzeichen) erhalten und unter der Voraussetzung, dass lokal eine\n                    Sepsis Triage und Management B\u00fcndel etabliert und implementiert wurde,\n                    ist eine TTA&lt;3\u2009h bei kinderonkologischen Patienten mit FN\n                    angemessen.<\/jats:p>","DOI":"10.1055\/a-2135-4210","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T22:54:30Z","timestamp":1695768870000},"page":"331-341","source":"Crossref","is-referenced-by-count":5,"title":["Time to Antibiotics (TTA) \u2013 \u00dcberlegungen der\n                    Arbeitsgruppe Fieber bei Granulozytopenie im Kindes- und Jugendalter\n                    (GPOH\/DGPI) zu einer Neubewertung."],"prefix":"10.1055","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9558-3330","authenticated-orcid":false,"given":"Arne","family":"Simon","sequence":"additional","affiliation":[{"name":"P\u00e4diatrische Onkologie und H\u00e4matologie,\n                    Universit\u00e4tskinderklinik Homburg, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lehrnbecher","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinder- und Jugendheilkunde, Klinikum der\n                    Johann-Wolfgang-Goethe-Universit\u00e4t, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeliz","family":"Baltaci","sequence":"additional","affiliation":[{"name":"P\u00e4diatrische Onkologie und H\u00e4matologie, TeleKasper\n                    Projekt, Universit\u00e4tskinderklinik Homburg, Homburg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8973-5406","authenticated-orcid":false,"given":"Christian","family":"Dohna-Schwake","sequence":"additional","affiliation":[{"name":"Kinderklinik 1, Universit\u00e4tsklinik Essen, Essen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Groll","sequence":"additional","affiliation":[{"name":"P\u00e4d. H\u00e4matologie und Onkologie, Univ.-Klinikum\n                    M\u00fcnster, Klinik f\u00fcr Kinder- und Jugendmedizin, M\u00fcnster,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-J\u00fcrgen","family":"Laws","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinder-Onkologie, \u2013 H\u00e4matologie und\n                    \u2013 Klinische Immunologie, Universerstit\u00e4tsklinikum\n                    D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Potratz","sequence":"additional","affiliation":[{"name":"P\u00e4diatrische Onkologie und H\u00e4matologie,\n                    Universit\u00e4tskinderklinik M\u00fcnster, Muenster,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Hufnagel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinderheilkunde und Jugendmedizin,\n                    Universit\u00e4tskinderklinik Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Bochennek","sequence":"additional","affiliation":[{"name":"P\u00e4diatrische H\u00e4matologie und Onkologie,\n                    Universit\u00e4tsklinik Frankfurt, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.critrevonc.2019.07.014","article-title":"PICU mortality of children with cancer admitted to pediatric intensive care unit\n                    a systematic review and meta-analysis","volume":"142","author":"R M W\u00f6sten-van Asperen","year":"2019","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e583","DOI":"10.1097\/MPH.0000000000001718","article-title":"Treatment of 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                and neutropenia during chemotherapy for cancer (FN), a systematic review","volume":"28","author":"C Koenig","year":"2020","journal-title":"Support Care Cancer"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"14028","DOI":"10.1038\/s41598-022-18168-x","article-title":"Time to antibiotics is unrelated to outcome in pediatric patients with fever in\n                    neutropenia presenting without severe disease during chemotherapy for\n                    cancer","volume":"12","author":"C Koenig","year":"2022","journal-title":"Scientific reports"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S2352-4642(20)30092-4","article-title":"39\u00b70\u00b0C versus 38\u00b75\u00b0C ear temperature as fever\n                    limit in children with neutropenia undergoing chemotherapy for cancer: a\n                    multicentre, cluster-randomised, multiple-crossover, non-inferiority trial","volume":"4","author":"C 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