{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:53:39Z","timestamp":1770278019436,"version":"3.49.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idiopathic isolated adrenocorticotrophic hormone deficiency (IIAD) is rare, with\n                    high clinical omission and misdiagnosis rates. This study retrospectively\n                    collected information on clinical presentation, laboratory findings, and\n                    treatment response of 17 patients with IIAD at Jining No. 1 People's\n                    Hospital from January 2014 to December 2022. The clinical characteristics were\n                    summarized, and the pertinent data were analyzed. As a result, most of the\n                    patients with IIAD were male (94.12%), with age at onset ranging from 13\n                    to 80 years. The primary manifestations were anorexia (88.24%), nausea\n                    (70.59%), vomiting (47.06%), fatigue (64.71%), and\n                    neurological or psychiatric symptoms (88.24%). The median time to\n                    diagnosis was 2 months and the longest was 10 years. Laboratory tests mostly\n                    showed hyponatremia (88.24%) and hypoglycemia (70.59%). The\n                    symptoms and laboratory indicators returned to normal after supplementing\n                    patients with glucocorticoids. IIAD has an insidious onset and atypical\n                    symptoms; it was often misdiagnosed as gastrointestinal, neurological, or\n                    psychiatric disease. The aim of this study was to improve clinicians'\n                    understanding of IIAD, patients with unexplained gastrointestinal symptoms,\n                    neurological and psychiatric symptoms, hyponatremia, or hypoglycemia should be\n                    evaluated for IIAD and ensure early diagnosis and treatment.<\/jats:p>","DOI":"10.1055\/a-2135-7708","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:46:47Z","timestamp":1694213207000},"page":"523-531","source":"Crossref","is-referenced-by-count":3,"title":["Idiopathic Isolated Adrenocorticotropic Hormone Deficiency: A\n                    Single-Center Retrospective Study"],"prefix":"10.1055","volume":"131","author":[{"given":"Chengyan","family":"Yang","sequence":"additional","affiliation":[{"name":"Shandong First Medical University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinpei","family":"Li","sequence":"additional","affiliation":[{"name":"Jining Medical University, Jining, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Jining No 1 People\u02bcs Hospital, Jining, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"ref1","first-page":"1519","volume":"14","author":"A Steinberg","year":"1954","journal-title":"True pituitary Addison's disease, a pituitary unitropic\n                    deficiency; 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