{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:48:33Z","timestamp":1790707713577,"version":"4.1.0"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"12","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>Background\u2002In the Dutch colorectal (CRC) screening program, fecal immunochemical test (FIT)-positive individuals are referred for colonoscopy. If no relevant findings are detected at colonoscopy, individuals are reinvited for FIT screening after 10 years. We aimed to assess CRC risk after a negative colonoscopy in FIT-positive individuals.<\/jats:p>\n                  <jats:p>Methods\u2002In this cross-sectional cohort study, data were extracted from the Dutch national screening information system. Participants with a positive FIT followed by a negative colonoscopy between 2014 and 2018 were included. A negative colonoscopy was defined as a colonoscopy during which no more than one nonvillous, nonproximal adenoma &lt;\u200a10\u200amm or serrated polyp &lt;\u200a10\u200amm was found. The main outcome was interval post-colonoscopy CRC (iPCCRC) risk. iPCCRC risk was reviewed against the risk of interval CRC after a negative FIT (FIT IC) with a 2-year screening interval.<\/jats:p>\n                  <jats:p>Results\u200235\u2005052 FIT-positive participants had a negative colonoscopy and 24 iPCCRCs were diagnosed, resulting in an iPCCRC risk of 6.85 (95\u200a%CI 4.60\u201310.19) per 10\u2005000 individuals after a median follow-up of 1.4 years. After 2.5 years of follow-up, age-adjusted iPCCRC risk was approximately equal to FIT IC risk at 2 years.<\/jats:p>\n                  <jats:p>Conclusion\u2002Risk of iPCCRC within a FIT-based CRC screening program was low during the first years after colonos-copy but, after 2.5 years, was the same as the risk in FIT-negative individuals at 2 years, when they are reinvited for screening. Colonoscopy quality may therefore require further improvement and FIT screening interval may need to be reduced after negative colonoscopy.<\/jats:p>","DOI":"10.1055\/a-2136-6564","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T18:53:51Z","timestamp":1696445631000},"page":"1061-1069","source":"Crossref","is-referenced-by-count":13,"title":["Interval post-colonoscopy colorectal cancer following a negative colonoscopy in a fecal immunochemical test-based screening program"],"prefix":"10.1055","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0543-4225","authenticated-orcid":false,"given":"Hilliene J.","family":"van de Schootbrugge-Vandermeer","sequence":"first","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6324-0931","authenticated-orcid":false,"given":"Arthur I.","family":"Kooyker","sequence":"first","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-9757","authenticated-orcid":false,"given":"Manon C. W.","family":"Spaander","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique E.","family":"van Leerdam","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands"},{"name":"Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter H. A.","family":"Wisse","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris D.","family":"Nagtegaal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Radboud University Medical Centre, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiltje A.","family":"Geuzinge","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4001-2949","authenticated-orcid":false,"given":"Esther","family":"Toes-Zoutendijk","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie C. H.","family":"Breekveldt","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke J.","family":"van Vuuren","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folkert J.","family":"van Kemenade","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian R. B.","family":"Ramakers","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4363-0745","authenticated-orcid":false,"given":"Evelien","family":"Dekker","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, location AMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Lansdorp-Vogelaar","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"H Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1002\/cncr.29462","article-title":"Effectiveness of fecal immunochemical testing in reducing colorectal cancer mortality from the One Million Taiwanese Screening Program","volume":"121","author":"H M Chiu","year":"2015","journal-title":"Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/ajg.2015.240","article-title":"Impact of screening program on incidence of colorectal cancer: a cohort study in Italy","volume":"110","author":"Rossi P Giorgi","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1053\/j.gastro.2018.07.017","article-title":"Effects of organized colorectal cancer screening on cancer incidence and mortality in a large community-based population","volume":"155","author":"T R Levin","year":"2018","journal-title":"Gastroenterology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1136\/gutjnl-2014-309086","article-title":"Colorectal cancer screening: a global overview of existing programmes","volume":"64","author":"E H Schreuders","year":"2015","journal-title":"Gut"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1136\/gutjnl-2017-314753","article-title":"Long-term performance of colorectal cancer screening programmes based on the faecal immunochemical test","volume":"67","author":"M Zorzi","year":"2018","journal-title":"Gut"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1055\/s-0033-1344548","article-title":"Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline","volume":"45","author":"C Hassan","year":"2013","journal-title":"Endoscopy"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1136\/gut.2005.087130","article-title":"Does a negative screening colonoscopy ever need to be repeated?","volume":"55","author":"H Brenner","year":"2006","journal-title":"Gut"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1200\/JCO.2011.35.9307","article-title":"Long-term risk of colorectal cancer after negative colonoscopy","volume":"29","author":"H Brenner","year":"2011","journal-title":"J Clin Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cgh.2008.05.016","article-title":"Risk of developing proximal versus distal colorectal cancer after a negative colonoscopy: a population-based study","volume":"6","author":"J Lakoff","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1056\/NEJMoa1301969","article-title":"Long-term colorectal-cancer incidence and mortality after lower endoscopy","volume":"369","author":"R Nishihara","year":"2013","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7326\/M19-2477","article-title":"Long-term colorectal cancer incidence and mortality after a single negative screening colonoscopy","volume":"173","author":"N D Pilonis","year":"2020","journal-title":"Ann Intern Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1001\/jama.295.20.2366","article-title":"Risk of developing colorectal cancer following a negative colonoscopy examination: evidence for a 10-year interval between colonoscopies","volume":"295","author":"H Singh","year":"2006","journal-title":"JAMA"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1136\/gutjnl-2011-301531","article-title":"Interval cancers after negative colonoscopy: population-based case-control study","volume":"61","author":"H Brenner","year":"2012","journal-title":"Gut"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.medcli.2017.04.015","article-title":"Post-colonoscopy colorectal cancer: characteristics and predictive factors","volume":"150","author":"M Munoz Garcia-Borruel","year":"2018","journal-title":"Med Clin (Barc)"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/gutjnl-2013-304880","article-title":"Postcolonoscopy colorectal cancers are preventable: a population-based study","volume":"63","author":"C M le Clercq","year":"2014","journal-title":"Gut"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1136\/gutjnl-2020-320761","article-title":"Faecal immunochemical test after negative colonoscopy may reduce the risk of incident colorectal cancer in a population-based screening programme","volume":"70","author":"S M Peng","year":"2021","journal-title":"Gut"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1038\/ajg.2015.365","article-title":"Interval colorectal cancer after colonoscopy: exploring explanations and solutions","volume":"110","author":"J Adler","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"E1140","DOI":"10.1055\/a-0650-4296","article-title":"Colorectal cancer after negative colonoscopy in fecal immunochemical test-positive participants from a colorectal cancer screening program","volume":"6","author":"L Rivero-Sanchez","year":"2018","journal-title":"Endosc Int Open"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.3390\/cancers13205105","article-title":"Analysis of post-colonoscopy colorectal cancer and its subtypes in a screening programme","volume":"13","author":"S Unanue-Arza","year":"2021","journal-title":"Cancers (Basel)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1053\/j.gastro.2016.11.022","article-title":"Real-time monitoring of results during first year of Dutch colorectal cancer screening program and optimization by altering fecal immunochemical test cut-off levels","volume":"152","author":"E Toes-Zoutendijk","year":"2017","journal-title":"Gastroenterology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1373\/clinchem.2018.294041","article-title":"Quality monitoring of a FIT-based colorectal cancer screening program","volume":"65","author":"E Toes-Zoutendijk","year":"2019","journal-title":"Clin Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1055\/s-0042-104275","article-title":"Developing a score chart to improve risk stratification of patients with colorectal adenoma","volume":"48","author":"E M van Heijningen","year":"2016","journal-title":"Endoscopy"},{"key":"ref24","first-page":"19","article-title":"Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive","volume":"29","author":"M Casparie","year":"2007","journal-title":"Cell Oncol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1053\/j.gastro.2018.05.038","article-title":"World Endoscopy Organization consensus statements on post-colonoscopy and post-imaging colorectal cancer","volume":"155","author":"M D Rutter","year":"2018","journal-title":"Gastroenterology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","article-title":"The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM","volume":"17","author":"S B Edge","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.cgh.2019.08.021","article-title":"Incidence of interval colorectal cancer after negative results from first-round fecal immunochemical screening tests, by cutoff value and participant sex and age","volume":"18","author":"E Toes-Zoutendijk","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"E1149","DOI":"10.1055\/a-0655-1987","article-title":"Colorectal cancer screening program using FIT: quality of colonoscopy varies according to hospital type","volume":"6","author":"I Portillo","year":"2018","journal-title":"Endosc Int Open"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1001\/jamainternmed.2018.5565","article-title":"Long-term risk of colorectal cancer and related deaths after a colonoscopy with normal findings","volume":"179","author":"J K Lee","year":"2019","journal-title":"JAMA Intern Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1136\/gutjnl-2014-308362","article-title":"Post-colonoscopy colorectal cancer (PCCRC) rates vary considerably depending on the method used to calculate them: a retrospective observational population-based study of PCCRC in the English National Health Service","volume":"64","author":"E J Morris","year":"2015","journal-title":"Gut"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1136\/gutjnl-2014-307992","article-title":"Definition and taxonomy of interval colorectal cancers: a proposal for standardising nomenclature","volume":"64","author":"S Sanduleanu","year":"2015","journal-title":"Gut"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S2468-1253(22)00090-5","article-title":"Serrated polyp detection and risk of interval post-colonoscopy colorectal cancer: a population-based study","volume":"7","author":"D van Toledo","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.7326\/M22-0301","article-title":"Adenoma detection rate and risk for interval postcolonoscopy colorectal cancer in fecal immunochemical test-based screening: a population-based cohort study","volume":"175","author":"P HA Wisse","year":"2022","journal-title":"Ann Intern Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.cgh.2012.12.004","article-title":"Serrated colon polyps as precursors to colorectal cancer","volume":"11","author":"S Sweetser","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1053\/j.gastro.2012.09.043","article-title":"Incomplete polyp resection during colonoscopy \u2013 results of the complete adenoma resection (CARE) study","volume":"144","author":"H Pohl","year":"2013","journal-title":"Gastroenterology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1136\/gutjnl-2014-308908","article-title":"Monitoring postcolonoscopy colorectal cancers: dangerous crossroads?","volume":"64","author":"S Sanduleanu","year":"2015","journal-title":"Gut"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e0254021","DOI":"10.1371\/journal.pone.0254021","article-title":"Optimal cut-off value for detecting colorectal cancer with fecal immunochemical tests according to age and sex","volume":"16","author":"M Vanaclocha-Espi","year":"2021","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gie.2018.09.011","article-title":"Quality assurance of colonoscopy within the Dutch national colorectal cancer screening program","volume":"89","author":"M ES Bronzwaer","year":"2019","journal-title":"Gastrointest Endosc"},{"key":"ref39","volume-title":"Protocol for the authorization and auditing of colonoscopy centers and endoscopists. National screening programme for bowel cancer, 9th version","author":"National Institute for Public Health and the Environment","year":"2020"}],"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2136-6564.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T18:30:49Z","timestamp":1701196249000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2136-6564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,4]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,11,28]]},"published-print":{"date-parts":[[2023,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2136-6564","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,4]]}}}