{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:54:35Z","timestamp":1775476475484,"version":"3.50.1"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a lack of long-term data on the benefit of growth hormone (GH) treatment\n                    in Chinese children born small for gestational age (SGA). This study was\n                    conducted to assess the long-term efficacy and safety of GH treatment in\n                    children born SGA. One hundred and twenty prepubertal SGA children who did not\n                    achieve catch-up growth with height remained less than \u20132 standard\n                    deviations (SD) below gender-specific height were enrolled in this two-year,\n                    randomized, dose-comparative study followed by an extension study of up to 10\n                    years. Daily subcutaneous injections of 0.23\u2009mg\/kg\/week\n                    [low-dose (LD) group] or 0.46\u2009mg\/kg\/week [high-dose (HD)\n                    group] somatropin were given for 104 weeks. Dosing in the extension study\n                    was\u22640.46\u2009mg\/kg\/week. The main outcome measures\n                    were change in height SD score (\u0394HT-SDS), height velocity, insulin-like\n                    growth factor (IGF)-1, and IGF-1\/IGF binding protein-3 (IGFBP-3) molar\n                    ratio. \u0394HT-SDS at week 104 was 0.91\u00b10.53 and 1.52\u00b10.64\n                    in the LD and HD groups (intergroup p&lt;0.0001), respectively, and\n                    continued in an upward trend throughout the extension study, remaining\n                    above+2 for those who received treatment for a total of 7 years or more.\n                    At week 104, significant improvements were observed in height velocity, IGF-1\n                    SDS, and IGF-1\/IGFBP-3 molar ratio. Adult HT-SDS was\n                    \u20130.81\u00b11.68 for boys and \u20130.82\u00b11.05 for girls\n                    (p=0.9837). Glucose metabolism and thyroid function were within the\n                    normal reference range throughout treatment. Long-term recombinant human GH\n                    treatment was tolerable and effective at improving height in children born\n                    SGA.<\/jats:p>","DOI":"10.1055\/a-2136-8654","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T22:57:51Z","timestamp":1694127471000},"page":"599-609","source":"Crossref","is-referenced-by-count":4,"title":["Long-Term Efficacy and Safety of Recombinant Human Growth Hormone in\n                    Children Born Small for Gestational Age"],"prefix":"10.1055","volume":"55","author":[{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong\n                    University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxiu","family":"Gong","sequence":"additional","affiliation":[{"name":"Endocrine and Genetics and Metabolism, Beijing Children\u2019s\n                    Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchuan","family":"Li","sequence":"additional","affiliation":[{"name":"Endocrine and Genetics and Metabolism, Beijing Children\u2019s\n                    Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Hu","sequence":"additional","affiliation":[{"name":"Pediatrics, Jiangsu Provincial People\u2019s Hospital, Jiangsu,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihong","family":"Gong","sequence":"additional","affiliation":[{"name":"Pediatrics, Jiangsu Provincial People\u2019s Hospital, Jiangsu,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfen","family":"Fu","sequence":"additional","affiliation":[{"name":"Endocrinology, Children\u2019s Hospital of Zhejiang University\n                    School of Medicine, National Clinical Research Center for Child Health,\n                    Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Huang","sequence":"additional","affiliation":[{"name":"Endocrinology, Children\u2019s Hospital of Zhejiang University\n                    School of Medicine, National Clinical Research Center for Child Health,\n                    Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pin","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Genetics and Endocrinology, Children\u2019s Hospital\n                    Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai\n                    Children\u2019s Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Luo","sequence":"additional","affiliation":[{"name":"Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong\n                    University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000365790","article-title":"Global prevalence of small for gestational age births","volume":"81","author":"R E Black","year":"2015","journal-title":"Nestle Nutr Inst Workshop Ser"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2018-00083","article-title":"Children born small for gestational age: differential diagnosis, molecular\n                    genetic evaluation, and implications","volume":"39","author":"MJ J Finken","year":"2018","journal-title":"Endocr Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1210\/jc.2006-2017","article-title":"Management of the child born small for gestational age through to adulthood: a\n                    consensus statement of the International Societies of Pediatric 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(Oxf)"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1016\/S2214-109X(13)70006-8","article-title":"National and regional estimates of term and preterm babies born small for\n                    gestational age in 138 low-income and middle-income countries in 2010","volume":"1","author":"A C Lee","year":"2013","journal-title":"Lancet Glob Health"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e105155","DOI":"10.1371\/journal.pone.0105155","article-title":"Risk factors and adverse perinatal outcomes among term and preterm infants born\n                    small-for-gestational-age: secondary analyses of the WHO multi-country survey on\n                    maternal and newborn health","volume":"9","author":"E Ota","year":"2014","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"864908","DOI":"10.3389\/fendo.2022.864908","article-title":"A randomized controlled phase 3 study on the efficacy and safety of 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Pediatr Endocrinol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1159\/000479691","article-title":"Circulating IGF-I, IGFBP-3 and the IGF-I\/IGFBP-3 molar ratio\n                    concentration and height outcome in prepubertal short children on rhGH treatment\n                    over two years of therapy","volume":"88","author":"M G Ballerini","year":"2017","journal-title":"Horm Res Paediatr"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.6065\/apem.2040096.048","article-title":"Factors influencing growth hormone therapy effect during the prepubertal period\n                    in small for gestational age children without catch-up growth","volume":"26","author":"C D Kum","year":"2021","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"ref26","first-page":"105","article-title":"Increases in bioactive IGF do not parallel increases in total IGF-I during\n                    growth hormone treatment of children born 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treatment with recombinant growth hormone","volume":"84","author":"A J Swerdlow","year":"2015","journal-title":"Horm Res Paediatr"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"671361","DOI":"10.3389\/fendo.2021.671361","article-title":"Genetic screening for growth hormone therapy in children small for gestational\n                    age: so much to consider, still much to discover","volume":"12","author":"C Giacomozzi","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000329372","article-title":"The use of bone age in clinical practice \u2013 part 1","volume":"76","author":"D D Martin","year":"2011","journal-title":"Horm Res Paediatr"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000508190","article-title":"Safety and effectiveness of omnitrope(R), a biosimilar recombinant human growth\n                    hormone: more than 10 years\u2019 experience from the PATRO Children\n                    study","volume":"93","author":"R Pfaffle","year":"2020","journal-title":"Horm Res Paediatr"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1297\/cpe.29.159","article-title":"The long-term safety and effectiveness of growth hormone treatment in Japanese\n                    children with short stature born small for gestational age","volume":"29","author":"R Horikawa","year":"2020","journal-title":"Clin Pediatr Endocrinol"},{"key":"ref34","first-page":"15","article-title":"Birth size, postnatal growth and growth during growth hormone treatment in\n                    small-for-gestational-age children: associations with IGF1 gene polymorphisms\n                    and haplotypes?","volume":"72","author":"W A Ester","year":"2009","journal-title":"Horm Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1210\/jc.2005-1581","article-title":"The d3-growth hormone (GH) receptor polymorphism is associated with increased\n                    responsiveness to GH in Turner syndrome and short small-for-gestational-age\n                    children","volume":"91","author":"G Binder","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref36","first-page":"402","article-title":"Insulin resistance in short children with intrauterine growth retardation","volume":"82","author":"P L Hofman","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1067\/mpd.2003.8","article-title":"Reduced insulin sensitivity during growth hormone therapy for short children\n                    born small for gestational age","volume":"142","author":"W S Cutfield","year":"2003","journal-title":"J Pediatr"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2136-8654.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T22:58:18Z","timestamp":1694127498000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2136-8654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":35,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2023,9,7]]},"published-print":{"date-parts":[[2023,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2136-8654","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]}}}