{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:50Z","timestamp":1740126830063,"version":"3.37.3"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective We aimed to investigate serum amphiregulin (AREG) concentrations\n                    in pregnant women with isolated fetal growth restriction (FGR) in the third\n                    trimester.<\/jats:p><jats:p>\n          Materials and methods This cross-sectional study was conducted with 90\n                    pregnant women who applied to the Umraniye Training and Research Hospital\n                    Gynecology and Obstetrics Clinic between January 2022 and May 2022. The FGR\n                    group consisted of 45 pregnant women diagnosed with FGR in the third trimester,\n                    and the control group consisted of 45 healthy pregnant women matched with the\n                    FGR group in terms of age and body mass index (BMI). Demographic\n                    characteristics, ultrasound findings, and neonatal outcomes were noted. As a\n                    primary outcome, the two groups were compared for maternal serum AREG\n                    concentrations.<\/jats:p><jats:p>\n          Results Both groups were similar in terms of demographic characteristics\n                    (p&gt;0.05). While fetal BPD, AC, and FL measurements in the group\n                    diagnosed with FGR were significantly lower than in the control group, umbilical\n                    artery Doppler PI and S\/D were higher (p=0.000, for all).\n                    Gestational age at birth, newborn birth weight, birth height, and 1-minute Apgar\n                    score were significantly lower and the NICU admission rate was higher in the FGR\n                    group (p=0.000, p=0.000, p=0.000, p=0.027,\n                    p=0.011 respectively). Gestational age at blood sampling for AREG was\n                    similar in both groups (p=0.869). While maternal serum AREG\n                    concentration was 969.39\u2009ng\/L in the FGR group, it was\n                    795.20\u2009ng\/L in the control group (p=0.018). AUC analysis\n                    of AREG for estimation of FGR in ROC analysis was 0.57 (p&lt;0.247,\n                    95% CI=0.44\u20130.69). The optimal threshold value for FGR\n                    estimation of maternal serum AREG concentration was determined as\n                    874.03\u2009ng\/L with 55% sensitivity and 55%\n                    specificity.<\/jats:p><jats:p>\n          Conclusion High maternal serum AREG concentrations appear to be associated\n                    with isolated FGR in the third trimester. The pathways through which AREG\n                    modulates fetal growth remain to be investigated.<\/jats:p>","DOI":"10.1055\/a-2140-7110","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T23:03:01Z","timestamp":1693004581000},"page":"161-165","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of Serum Amphiregulin Concentrations in Pregnant Women\n                    Diagnosed with Isolated Fetal Growth Restriction in the Third\n                    Trimester"],"prefix":"10.1055","volume":"228","author":[{"given":"Fatma \u0130smail Ali","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Umraniye Training and Research Hospital,\n                    Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-7199","authenticated-orcid":false,"given":"\u0130brahim","family":"Kale","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Umraniye Training and Research Hospital,\n                    Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berna Buse","family":"Kobal","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Tuzla State Hospital, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysegul","family":"Ozel","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Maternal Fetal Unit, Umraniye Training and\n                    Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Muhcu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Maternal Fetal Unit, Umraniye Training and\n                    Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3389\/fendo.2020.00205","article-title":"Editorial: Causes and consequences of \u0131ntrauterine growth\n                    restriction","volume":"11","author":"I Bendix","year":"2020","journal-title":"Front Endocrinol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/tpj.2013.29","article-title":"Intergenic polymorphisms in the amphiregulin gene region as biomarkers in\n                    metastatic colorectal cancer patients treated with anti-EGFR plus\n                    irinotecan","volume":"14","author":"A Sebio","year":"2014","journal-title":"Pharmacogenomics J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1128\/mcb.10.5.1969-1981.1990","article-title":"The amphiregulin gene encodes a novel epidermal growth factor-related protein\n                    with tumor-inhibitory activity","volume":"10","author":"G D Plowman","year":"1990","journal-title":"Mol Cell Biol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.clinbiochem.2011.12.029","article-title":"Normal range of serum amphiregulin in healthy adult human females","volume":"45","author":"E A Peterson","year":"2012","journal-title":"Clin Biochem"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nrm3048","article-title":"Feedback regulation of EGFR signalling: decision making by early and delayed\n                    loops","volume":"12","author":"R Avraham","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/0143-4004(95)90093-4","article-title":"Localization of amphiregulin in the human placenta and decidua throughout\n                    gestation: role in trophoblast growth","volume":"16","author":"J J Lysiak","year":"1995","journal-title":"Placenta"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/uog.22134","article-title":"ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age\n                    fetus and fetal growth restriction","volume":"56","author":"C C Lees","year":"2020","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.semcdb.2014.01.005","article-title":"Amphiregulin","volume":"28","author":"C Berasain","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"116899","DOI":"10.1016\/j.lfs.2019.116899","article-title":"Amphiregulin promotes trophoblast invasion and increases MMP9\/TIMP1\n                    ratio through ERK1\/2 and Akt signal pathways","volume":"236","author":"Y Yu","year":"2019","journal-title":"Life Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.lfs.2009.03.009","article-title":"Amphiregulin regulates the production of human chorionic gonadotropin in\n                    trophoblasts","volume":"84","author":"T Fukami","year":"2009","journal-title":"Life Sci"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.placenta.2021.07.292","article-title":"Amphiregulin stimulates human chorionic gonadotropin expression by inducing\n                    ERK1\/2-mediated ID3 expression in trophoblast cells","volume":"112","author":"L Fang","year":"2021","journal-title":"Placenta"},{"key":"ref12","first-page":"7575","article-title":"Regulation of extracellular matrix metalloproteinase inducer and matrix\n                    metalloproteinase expression by amphiregulin in transformed human breast\n                    epithelial cells","volume":"63","author":"S Menashi","year":"2003","journal-title":"Cancer Res"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1002\/(sici)1097-0215(19970317)70:6<722::aid-ijc15>3.0.co;2-b","article-title":"Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9\n                    (MMP-9) in human breast cancer cells","volume":"70","author":"S B Kondapaka","year":"1997","journal-title":"Int J Cancer"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1080\/14767058.2019.1671345","article-title":"Serum amphiregulin and cerebellin-1 levels in severe preeclampsia","volume":"34","author":"\u00d6 G\u00fcler","year":"2021","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1600-0897.1989.tb01009.x","article-title":"Expression of epidermal growth factor receptor and transferrin receptor by human\n                    trophoblast populations","volume":"21","author":"J N Bulmer","year":"1989","journal-title":"Am J Reprod Immunol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1515\/JPEM.1994.7.4.295","article-title":"Epidermal growth factor receptor and human fetoplacental development","volume":"7","author":"D Evain-Brion","year":"1994","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S0143-4004(85)80005-9","article-title":"Epidermal growth factor binding and receptor distribution in term human\n                    placenta","volume":"6","author":"M Magid","year":"1985","journal-title":"Placenta"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2140-7110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:54:38Z","timestamp":1730825678000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2140-7110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,25]]},"references-count":17,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2024,4,12]]},"published-print":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2140-7110","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"type":"print","value":"0948-2393"},{"type":"electronic","value":"1439-1651"}],"subject":[],"published":{"date-parts":[[2023,8,25]]}}}