{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:23:21Z","timestamp":1761218601335,"version":"3.28.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Perioperative cardioprotection is essential for achieving satisfactory clinical outcomes in heart failure patients. It is important to understand the factors affecting perioperative cardioprotection.<\/jats:p><jats:p>\n          Methods\u2003The institutional database was searched for patients with reduced ejection fraction (EF,\u2009&lt;\u200940%) who underwent surgery with cardioplegia-induced arrest. Patients were divided into del Nido cardioplegia (DN) and cold blood cardioplegia (CB) groups. The relationships between age, preoperative blood parameters, creatinine, cross-clamp time (CCT), extracorporeal circulation time (ECT), and postoperative troponin values at 12\u2009hours or deterioration of EF (\u22655%) were evaluated. Baseline characteristics, operative parameters, and outcomes were analyzed.<\/jats:p><jats:p>\n          Results\u2003There were 508 patients with reduced EF (331 DN and 177 CB). In the entire cohort, anemic patients had greater troponin values (p\u2009=\u20090.004) as well as in the DN group (p\u2009=\u20090.002). However, this was not detected in the CB group (flat regression line; p\u2009=\u20090.674). Patients with high leukocyte values had greater troponin release (entire cohort: p\u2009&lt;\u20090.001; DN group: p\u2009&lt;\u20090.001; CB group: steep regression line with p\u2009=\u20090.042). Longer CCT and ECT were associated with greater troponin release (entire cohort; both groups) and greater risk of fall in EF. In a direct comparison, fewer patients had significant deterioration of EF in the DN group than CB group (3.9 vs. 11.9%; p\u2009&lt;\u20090.001).<\/jats:p><jats:p>\n          Conclusion\u2003The use of CB cardioplegia may be beneficial in anemic patients, whereas the use of DN cardioplegia may be beneficial for expected long CCT and high leukocytosis.<\/jats:p>","DOI":"10.1055\/a-2141-8105","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T23:11:58Z","timestamp":1690413118000},"page":"489-497","source":"Crossref","is-referenced-by-count":2,"title":["Determinants of Inadequate Cardioprotection in Adult Patients with Left Ventricular Dysfunction"],"prefix":"10.1055","volume":"72","author":[{"given":"Krzysztof","family":"Sanetra","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Andrzej Frycz Modrzewski Krakow University, Bielsko-Bia\u0142a, Poland"},{"name":"Department of Cardiac Surgery, American Heart of Poland, Bielsko-Bia\u0142a, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Witold","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, American Heart of Poland, Bielsko-Bia\u0142a, Poland"},{"name":"Department of Cardiac Surgery, Academy of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr Pawe\u0142","family":"Buszman","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Research and Development, American Heart of Poland, Katowice, Poland"},{"name":"Department of Cardiology, Andrzej Frycz Modrzewski Krakow Univeristy, Krakow, Poland"},{"name":"Department of Cardiology, American Heart of Poland, Bielsko- Biala, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Mazur","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Andrzej Frycz Modrzewski Krakow Univeristy, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Milewski","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Research and Development, American Heart of Poland, Katowice, Poland"},{"name":"Department of Cardiology, American Heart of Poland, Bielsko- Biala, Poland"},{"name":"Department of Cardiology, Academy of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Ka\u017amierczak","sequence":"additional","affiliation":[{"name":"American Heart of Poland, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Bochenek","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, American Heart of Poland, Bielsko-Bia\u0142a, Poland"},{"name":"Department of Cardiac Surgery, Academy of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"ref1","first-page":"III84","article-title":"Does cardioplegia type affect outcome and survival in patients with advanced left ventricular dysfunction? Results from the CABG Patch Trial","volume":"102","author":"J E Flack III","year":"2000","journal-title":"Circulation"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1051\/ject\/201244098","article-title":"History and use of del Nido cardioplegia solution at Boston Children's Hospital","volume":"44","author":"G S Matte","year":"2012","journal-title":"J Extra Corpor Technol"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.jtcvs.2017.09.146","article-title":"The use of del Nido cardioplegia in adult cardiac surgery: a prospective randomized trial","volume":"155","author":"N Ad","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1016\/j.jtcvs.2019.05.083","article-title":"The del Nido versus cold blood cardioplegia in aortic valve replacement: a randomized trial","volume":"159","author":"K Sanetra","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.5761\/atcs.oa.18-00087","article-title":"Comparison of del Nido and intermittent warm blood cardioplegia in coronary artery bypass grafting surgery","volume":"25","author":"H A Ucak","year":"2019","journal-title":"Ann Thorac Cardiovasc Surg"},{"issue":"02","key":"ref6","first-page":"210","article-title":"2019 EACTS\/EACTA\/EBCP guidelines on cardiopulmonary bypass in adult cardiac surgery","volume":"57","author":"A Wahba","year":"2020","journal-title":"Eur J Cardiothorac Surg"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/S0022-5223(19)41007-6","article-title":"Advantages of blood cardioplegia over continuous coronary perfusion or intermittent ischemia. Experimental and clinical study","volume":"76","author":"D M Follette","year":"1978","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"18","key":"ref8","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"72","author":"K Thygesen","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"736214","DOI":"10.3389\/fmed.2021.736214","article-title":"Microcirculatory response to blood vs. crystalloid cardioplegia during coronary artery bypass grafting with cardiopulmonary bypass","volume":"8","author":"G Aykut","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1067\/mtc.2000.109707","article-title":"The effect of leukocyte-depleted blood cardioplegia in patients with severe left ventricular dysfunction: a randomized, double-blind study","volume":"120","author":"M Roth","year":"2000","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/ejcts\/ezs145","article-title":"Leukocyte filtration of blood cardioplegia attenuates myocardial damage and inflammation","volume":"43","author":"F Onorati","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.athoracsur.2006.03.002","article-title":"Age- and gender-related differences in ischemia\/reperfusion injury and cardioprotection: effects of diazoxide","volume":"82","author":"J D McCully","year":"2006","journal-title":"Ann Thorac Surg"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.athoracsur.2006.10.059","article-title":"Age- and gender-related differences in mitochondrial oxygen consumption and calcium with cardioplegia and 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Thorac Surg"},{"issue":"03","key":"ref17","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0022-5223(95)70274-1","article-title":"Risk factors of incomplete distribution of cardioplegic solution during coronary artery grafting","volume":"109","author":"C Quintilio","year":"1995","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0003-4975(10)63129-3","article-title":"Inadequate cardioplegic protection with obstructed coronary arteries","volume":"28","author":"C J Hilton","year":"1979","journal-title":"Ann Thorac Surg"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1540-8191.1987.tb00206.x","article-title":"A technique for selective graft perfusion during aortocoronary bypass","volume":"2","author":"B S Goldman","year":"1987","journal-title":"J Card Surg"},{"issue":"06","key":"ref20","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/BF02850208","article-title":"Comparison of simultaneous antegrade\/vein graft cardioplegia with antegrade cardioplegia for myocardial protection","volume":"23","author":"G Onem","year":"2006","journal-title":"Adv Ther"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s13019-014-0141-5","article-title":"Del Nido cardioplegia can be safely administered in high-risk coronary artery bypass grafting surgery after acute myocardial infarction: a propensity matched comparison","volume":"9","author":"H Yerebakan","year":"2014","journal-title":"J Cardiothorac Surg"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/0218492320966434","article-title":"Clinical outcomes of single-dose cardioplegia in high-risk coronary bypass","volume":"29","author":"S Gunaydin","year":"2021","journal-title":"Asian Cardiovasc Thorac 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