{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:38:14Z","timestamp":1770277094369,"version":"3.49.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Poly cystic ovary syndrome (PCOS) is considered as one of the common hormonal\n                    disorders affecting 6\u201320% of women in their reproductive age\n                    with characteristic features include anovulatory infertility, hyperandrogenism,\n                    cystic follicles and insulin resistance. The gene CYP play an important role in\n                    pathophysiology of hyperandrogenism associated with PCOS. An elevated androgens\n                    are reported in PCOS condition due to overexpression of the enzyme\n                        CYP450 17 \u03b1. As well as diminished levels of\n                    aromatase (CYP450 19) were observed in several hyperandrogenic PCOS\n                    patients. The powdered leafy material of Cinnamomum malabatrum was\n                    subjected to Soxhlet extraction. The plant extract was subjected to Gas\n                    chromatography-MS analysis (GC-MS), and the chromatogram obtained revealed the\n                    presence of active chemical constituents like 1(10),9(11)-B-Homolanistadiene for\n                    the first time and other potential compounds. Hypothesis has raised to interpret\n                    the efficiency of phytoconstituents of Cinnamomum malabatrum on these\n                    enzyme targets and which may be a novel drug candidate for the treatment and\n                    maintenance of hyperandrogenism associated with PCOS. Thus, the results obtained\n                    from the in-silico study of Cinnamomum malabatrum leaf extract\n                    using computational approaches indicate that the phytoconstituents have good\n                    affinities for the selected two key targets. ADME and PASS studies has been\n                    performed for active phytoconstituents homolanistadiene, \u03b2-sitosterol,\n                    cycloartenol and a pyrazole derivative, and results revealed the Lipinski\n                    drug-likeness and pharmacological potential. In conclusion, this work throws a\n                    new insight into the possibility of the active phytoconstituents on binding the\n                    two active CYP45017 \u03b1 and CYP45019 aromatase\n                    enzymes which facilitates development of novel compounds for hyperandrogenism\n                    associated with PCOS.<\/jats:p>","DOI":"10.1055\/a-2142-5774","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T23:01:31Z","timestamp":1692313291000},"page":"441-447","source":"Crossref","is-referenced-by-count":3,"title":["GC-MS analysis and in silico docking of constituents of Cinnamomum\n                    malabatrum against CYP450 17\u03b1 and CYP450 19 (Aromatase)- Key targets for\n                    hyperandrogenism"],"prefix":"10.1055","volume":"73","author":[{"given":"V.","family":"Soumya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical chemistry, Faculty of pharmacy, Sri\n                    Ramachandra Institute of Higher Education and Research, SRMC(DU) Porur, Chennai,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Deepa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical chemistry, Faculty of pharmacy, Sri\n                    Ramachandra Institute of Higher Education and Research, SRMC(DU) Porur, Chennai,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knolin.K.","family":"Thachil","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical chemistry, Faculty of Pharmacy, M.S.\n                    Ramaiah University of Applied Sciences, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Saravanan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, JSS College of Pharmacy, JSS Academy of\n                    Higher Education and Research, Ooty, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Hariprasad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, PSG College of Pharmacy, Peelamedu,\n                    Coimbatore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic ovary syndrome","volume":"370","author":"R J Norman","year":"2007","journal-title":"The Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related\n                    to polycystic ovary syndrome","volume":"81","author":"ESHRE TR, ASRM-Sponsored PCOS Consensus Workshop\n                            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In Computational Peptidology","author":"F J Duffy","year":"2015"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1021\/ci500467k","article-title":"iLOGP: a simple, robust, and efficient description of n-octanol\/water\n                    partition coefficient for drug design using the GB\/SA approach","volume":"54","author":"A Daina","year":"2014","journal-title":"Journal of chemical information and modeling"}],"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2142-5774.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T23:22:17Z","timestamp":1695770537000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2142-5774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,17]]},"references-count":21,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2023,9,26]]},"published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2142-5774","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,17]]}}}