{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T13:11:42Z","timestamp":1747055502125},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Ultraschallgef\u00fchrte lokalablative Verfahren kommen als Erg\u00e4nzung zur chirurgischen Therapie und Radiojodtherapie zunehmend in der Routinebehandlung von Schilddr\u00fcsenknoten zur Anwendung. Bei rein zystischen und \u00fcberwiegend zystischen Herdbefunden liegen gute Erfahrungen mit der Instillationstherapie (Ethanol-\/Polidocanol-Ablation) vor. Die neueren thermoablativen Techniken, zu denen die Radiofrequenzablation (RFA), die Mikrowellenablation (MWA), die Laserablation (LA) und der hochintensive fokussierte Ultraschall (HIFU) z\u00e4hlen, erreichen mittels Temperaturen von \u00fcber 60 \u00b0C eine lokale Proteindenaturierung im Zielareal. Unter permanenter Ultraschallkontrolle kann so selektiv die Volumenreduktion lokal symptomatischer oder fokal hyperfunktioneller Befunde zur Erlangung von Beschwerdefreiheit induziert werden. W\u00e4hrend bereits vielf\u00e4ltige Evidenz f\u00fcr die effektive und sichere Anwendung verschiedener lokalablativer Techniken geschaffen werden konnte, liegen k\u00fcnftige Herausforderungen in der Initiierung komparativer prospektiver Studien sowie standardisierter Curricula zur Schulung und kontinuierlichen Qualit\u00e4tssicherung. Ferner wird es zuk\u00fcnftig angezeigt sein, die in Deutschland bei Patienten mitunter noch wenig bekannten lokalablativen Techniken im Aufkl\u00e4rungsgespr\u00e4ch als etablierte Alternative oder Erg\u00e4nzung zu bestehenden Therapieformen anzuf\u00fchren.<\/jats:p>","DOI":"10.1055\/a-2144-4132","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T18:49:10Z","timestamp":1695322150000},"page":"916-927","source":"Crossref","is-referenced-by-count":1,"title":["Ultraschallgef\u00fchrte lokalablative Verfahren zur Behandlung von Schilddr\u00fcsenl\u00e4sionen"],"prefix":"10.1055","volume":"102","author":[{"given":"Johannes-Paul","family":"Richter","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Nuklearmedizin, Universit\u00e4tsklinikum Magdeburg, Otto-von-Guericke-Universit\u00e4t, Magdeburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl-Philip","family":"Richter","sequence":"additional","affiliation":[{"name":"Chirurgische Klinik am Rathenauplatz, Schilddr\u00fcsenzentrum Baden-W\u00fcrttemberg, Heilbronn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Gr\u00f6ner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Nuklearmedizin, Universit\u00e4tsklinikum Frankfurt am Main, Frankfurt am Main"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1089\/105072503768499680","article-title":"The Prevalence of Undiagnosed Thyroid Disorders in a Previously Iodine-Deficient Area","volume":"13","author":"H V\u00f6lzke","year":"2003","journal-title":"Thyroid"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1089\/thy.2004.14.926","article-title":"Prevalence of Thyroid Disorders in the Working Population of Germany: Ultrasonography Screening in 96,278 Unselected Employees","volume":"14","author":"C Reiners","year":"2004","journal-title":"Thyroid"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1159\/000508484","article-title":"2020 European Thyroid Association Clinical Practice Guideline for the Use of Image-Guided Ablation in Benign Thyroid Nodules","volume":"9","author":"E Papini","year":"2020","journal-title":"European Thyroid J"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10354-019-0682-2","article-title":"Radiofrequency ablation of thyroid nodules: \u201cGood Clinical Practice Recommendations\u201d for Austria","author":"H Dobnig","year":"2019","journal-title":"Wien Med Wochenschr"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"632","DOI":"10.3348\/kjr.2018.19.4.632","article-title":"2017 Thyroid Radiofrequency Ablation Guideline: Korean Society of Thyroid Radiology","volume":"19","author":"J Kim","year":"2018","journal-title":"Korean J Radiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055\/a-1075-2025","article-title":"Non-Surgical and Non-Radioiodine Techniques for Ablation of Benign Thyroid Nodules: Consensus Statement and Recommendation*","author":"J Feldkamp","year":"2020","journal-title":"Exp Clin Endocr Diab"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/02656736.2019.1575482","article-title":"Minimally-invasive treatments for benign thyroid nodules: a Delphi-based consensus statement from the Italian minimally-invasive treatments of the thyroid (MITT) group","author":"E Papini","year":"2019","journal-title":"Int J Hyperther"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/hed.26960","article-title":"Radiofrequency ablation and related ultrasound-guided ablation technologies for treatment of benign and malignant thyroid disease: An international multidisciplinary consensus statement of the American Head and Neck Society Endocrine Surgery Section with the Asia Pacific Society of Thyroid Surgery, Associazione Medici Endocrinologi, British Association of Endocrine and Thyroid Surgeons, European Thyroid Association, Italian Society of Endocrine Surgery Units, Korean Society of Thyroid Radiology, Latin American Thyroid Society, and Thyroid Nodules Therapies Association","volume":"44","author":"LA Orloff","year":"2022","journal-title":"Head Neck"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1148\/radiology.175.3.2188302","article-title":"Treatment of autonomous thyroid nodules with percutaneous ethanol injection: preliminary results. 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