{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:10:39Z","timestamp":1762092639536,"version":"build-2065373602"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"11","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Medical Guidance Project of Shanghai Science and Technology Commission","award":["19401931100 to Wang XY"],"award-info":[{"award-number":["19401931100 to Wang XY"]}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"crossref","award":["21ZR1413200 to HM Yan"],"award-info":[{"award-number":["21ZR1413200 to HM Yan"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Research and Development Foundation of Zhongshan Hospital, Fudan University","award":["2019ZSFZ10 to HD LIN"],"award-info":[{"award-number":["2019ZSFZ10 to HD LIN"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aim This study investigated the effects of insulin glargine and exenatide\n                    on the muscle mass of patients with newly diagnosed type 2 diabetes (T2DM) and\n                    nonalcoholic fatty liver disease (NAFLD).<\/jats:p><jats:p>\n          Methods We performed a post-hoc analysis of our previously study, a\n                    24-week randomized controlled multicenter clinical trial (ClinicalTrials.gov,\n                    NCT02303730). Seventy-six patients were randomly assigned 1:1 to receive insulin\n                    glargine or exenatide treatment. The changes in psoas muscle area (PMA)\n                        (mm2) were obtained with the cross-sectional Dixonfat magnetic\n                    resonance images at the fourth lumber vertebra.<\/jats:p><jats:p>\n          Results There were no significant differences in age, BMI, gender, and PMA\n                    in insulin glargine and exenatide groups at baseline. After treatment, PMA\n                    tended to increase by 13.13 (\u2013215.52, 280.80) mm2 in the\n                    insulin glargine group and decrease by 149.09 (322.90\u201356.39)\n                        mm2 in the exenatide group (both p&gt;0.05). Subgroup\n                    analysis showed a 560.64 (77.88, 1043.40) (mm2) increase of PMA in\n                    the insulin group relative to the Exenatide group in patients with\n                        BMI&lt;28\u2009kg\/m2 (p0.031) after\n                    adjusting for gender, age, and research center. Interaction analysis showed an\n                    interaction between BMI and treatment (p0.009). However, no interaction\n                    was observed among subgroups with a\n                        BMI\u226528\u2009kg\/m2 or with different genders\n                    and ages.<\/jats:p><jats:p>\n          Conclusion Compared to exenatide, insulin glargine can relativity increase\n                    PMA in patients with T2DM having BMI&lt;28\u2009kg\/m2\n                    and NAFLD.<\/jats:p>","DOI":"10.1055\/a-2145-1004","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T22:55:51Z","timestamp":1690844151000},"page":"583-588","source":"Crossref","is-referenced-by-count":3,"title":["Insulin Glargine is More Suitable Than Exenatide in Preventing Muscle\n                    Loss in Non-Obese Type 2 Diabetic Patients with NAFLD"],"prefix":"10.1055","volume":"131","author":[{"given":"Lin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan\n                    University, Shanghai, China"},{"name":"Fudan Institute for Metabolic Disease, Fudan University, Shanghai,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruwen","family":"Wang","sequence":"first","affiliation":[{"name":"School of Kinesiology, Shanghai University of Sport, Shanghai,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Nutrition, Zhongshan Hospital, Fudan\n                    University"},{"name":"Center of Clinical Epidemiology and Evidence-based Medicine, Fudan\n                    University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Yan","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of\n                    Medicine and Health Sciences, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingtian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Zhongshan Hospital, Fudan\n                    University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhitian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan\n                    University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaojiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan\n                    University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huandong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan\n                    University, Shanghai, China"},{"name":"Fudan Institute for Metabolic Disease, Fudan University, Shanghai,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengxiang","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital, Fudan University,\n                    Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzhong","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital, Fudan University,\n                    Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Zhongshan Hospital, Fudan\n                    University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan\n                    University, Shanghai, China"},{"name":"Fudan Institute for Metabolic Disease, Fudan University, Shanghai,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Zhongshan Hospital, Fudan\n                    University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Shanghai University of Sport, Shanghai,\n                    China"},{"name":"School of Life Sciences, Fudan University, Shanghai,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan\n                    University, Shanghai, China"},{"name":"Fudan Institute for Metabolic Disease, Fudan University, Shanghai,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan\n                    University, Shanghai, China"},{"name":"Fudan Institute for Metabolic Disease, Fudan University, Shanghai,\n                    China"},{"name":"Department of Endocrinology and Metabolism, Wusong Branch of Zhongshan\n                    Hospital, Fudan University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"m997","DOI":"10.1136\/bmj.m997","article-title":"Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria\n                    from the American Diabetes Association: National cross 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Cho","year":"2018","journal-title":"Diabetes Res Clin Pract"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010183","article-title":"A narrative review on sarcopenia in type 2 diabetes mellitus: Prevalence and\n                    associated factors","volume":"13","author":"A Izzo","year":"2021","journal-title":"Nutrients"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"A J Cruz-Jentoft","year":"2019","journal-title":"Age and Ageing"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"101305","DOI":"10.1016\/j.arr.2021.101305","article-title":"The emerging role of the sympathetic nervous system in skeletal muscle motor\n                    innervation and sarcopenia","volume":"67","author":"O Delbono","year":"2021","journal-title":"Ageing Res 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A perspective case series study","volume":"28","author":"S Perna","year":"2016","journal-title":"Aging Clin Exp Res"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"293","DOI":"10.2174\/1573399816666200705210006","article-title":"Effects of antidiabetic drugs on muscle mass in type 2 diabetes mellitus","volume":"17","author":"S Ida","year":"2021","journal-title":"Curr Diabetes Rev"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00125-019-05065-8","article-title":"Effects of once-weekly semaglutide vs once-daily canagliflozin on body\n                    composition in type 2 diabetes: A substudy of the SUSTAIN 8 randomised\n                    controlled clinical trial","volume":"63","author":"R J McCrimmon","year":"2020","journal-title":"Diabetologia"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e3292","DOI":"10.1002\/dmrr.3292","article-title":"Efficacy of exenatide and insulin glargine on nonalcoholic fatty liver disease\n                    in patients with type 2 diabetes","volume":"36","author":"L Liu","year":"2020","journal-title":"Diabetes Metab Res Rev"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/j.1751-2980.2008.00331.x","article-title":"Guidelines for the diagnosis and treatment of nonalcoholic fatty liver\n                    diseases","volume":"9","author":"M D Zeng","year":"2008","journal-title":"J Dig Dis"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.2337\/diabetes.47.12.1824","article-title":"Differential regulation of amino acid exchange and protein dynamics across\n                    splanchnic and skeletal muscle beds by insulin in healthy human subjects","volume":"47","author":"S E Meek","year":"1998","journal-title":"Diabetes"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3433","DOI":"10.1172\/jci86522","article-title":"Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle\n                    proteostasis","volume":"126","author":"B T O'Neill","year":"2016","journal-title":"J Clin Invest"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1111\/dom.12680","article-title":"Exenatide decreases liver fat content and epicardial adipose tissue in patients\n                    with obesity and type 2 diabetes: A prospective randomized clinical trial using\n                    magnetic resonance imaging and spectroscopy","volume":"18","author":"A Dutour","year":"2016","journal-title":"Diabetes Obes Metab"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/jcsm.12434","article-title":"Amelioration of muscle wasting by glucagon-like peptide-1 receptor agonist in\n                    muscle atrophy","volume":"10","author":"Y Hong","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2145-1004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T23:41:18Z","timestamp":1700005278000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2145-1004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11,14]]},"published-print":{"date-parts":[[2023,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2145-1004","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"type":"print","value":"0947-7349"},{"type":"electronic","value":"1439-3646"}],"subject":[],"published-other":{"date-parts":[[2023,7,31]]},"published":{"date-parts":[[2023,7,31]]}}}