{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:04:16Z","timestamp":1783638256312,"version":"3.55.0"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to determine the effect of nonreassuring fetal heart rate (NRFHR) patterns in labor on the postnatal renal function of neonates with a prenatal diagnosis of congenital anomalies of the kidney and urinary tract (CAKUT).<\/jats:p><jats:p>\n            Study Design\u2003A retrospective cohort study was conducted in a single tertiary referral center between 2012 and 2020. All cases with a prenatal diagnosis of CAKUT were extracted, and their fetal, maternal, obstetrical, and neonatal characteristics were analyzed. Cases of multiple gestations, preterm delivery, small for gestational age, major associated malformations or genetic aberrations, and prelabor acute obstetrical events were excluded from the analysis. The study group was comprised of patients who experienced NRFHR during labor. The control groups included (1) patients who had a trial of labor with a normal fetal heart rate pattern and (2) patients who delivered by elective cesarean section (CS). The primary outcome was abnormal serum creatinine levels in the perinatal period. For statistical purposes, the CAKUT cases were classified into a low and high estimated risk for an abnormal postnatal renal outcome. A subgroup analysis of the results was performed accordingly.<\/jats:p><jats:p>\n            Results\u2003Two hundred and fifty-six fetuses diagnosed prenatally with CAKUT comprised the study group. Among these, 214 women (83%) opted for a labor trial, while 42 (17%) chose elective CS. Within the labor trial group, 21\/214 patients (9.8%) experienced NRFHR during labor. Analysis of maternal and fetal characteristics revealed no statistically significant disparities between the groups. NRFHR patterns were not associated with a deterioration in neonatal serum creatinine compared with those with normal fetal monitoring or those born by an elective CS.<\/jats:p><jats:p>\n            Conclusion\u2003NRFHR patterns during labor and delivery did not impair neonatal renal function status in fetuses diagnosed prenatally with low- and high-risk CAKUT. Delivery can be managed according to standard obstetrical guidelines.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2145-7636","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T23:03:20Z","timestamp":1690931000000},"page":"e2696-e2702","source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["Does a Nonreassuring Fetal Heart Rate Pattern Impair Renal Function in Neonates Prenatally Diagnosed with Congenital Anomalies of the Kidneys and Urinary Tract?"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6708-629X","authenticated-orcid":false,"given":"Yael","family":"Borovitz","sequence":"additional","affiliation":[{"name":"Nephrology Institute, Schneider Children's Hospital, Petach Tikva, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Allon","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5304-2296","authenticated-orcid":false,"given":"Miriam","family":"Lopian","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Israel"},{"name":"Department of Obstetrics and Gynecology, Maayanei Hayeshua Hospital, Bnei Brak, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinon","family":"Gilboa","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Israel"},{"name":"Prenatal Diagnostic Unit, The Helen Schneider Women's Hospital, Rabin Medical Center Beilinson Campus, Petach Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-0679","authenticated-orcid":false,"given":"Sharon","family":"Perlman","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Israel"},{"name":"Prenatal Diagnostic Unit, The Helen Schneider Women's Hospital, Rabin Medical Center Beilinson Campus, Petach Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"ref1","first-page":"S124","article-title":"Nephron mass as a risk factor for progression of renal disease","volume":"63","author":"B M Brenner","year":"1997","journal-title":"Kidney Int Suppl"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1056\/NEJMoa020549","article-title":"Nephron number in patients with primary hypertension","volume":"348","author":"G Keller","year":"2003","journal-title":"N Engl J Med"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1681\/ASN.2005020172","article-title":"Nephron number, hypertension, renal disease, and renal failure","volume":"16","author":"W E Hoy","year":"2005","journal-title":"J Am Soc Nephrol"},{"issue":"02","key":"ref4","first-page":"CD006066","article-title":"Continuous cardiotocography (CTG) as a form of electronic fetal monitoring (EFM) for fetal assessment during labour","volume":"2","author":"Z Alfirevic","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"07","key":"ref5","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0002-9378(83)90684-1","article-title":"The effect of reducing umbilical blood flow on fetal oxygenation","volume":"145","author":"J Itskovitz","year":"1983","journal-title":"Am J Obstet Gynecol"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0002-9378(16)32989-1","article-title":"Blood flow to fetal organs as a function of arterial oxygen content","volume":"135","author":"L L Peeters","year":"1979","journal-title":"Am J Obstet Gynecol"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/bdrc.21084","article-title":"Congenital anomalies of the kidney and urinary tract: an embryogenetic review","volume":"102","author":"A C dos Santos Junior","year":"2014","journal-title":"Birth Defects Res C Embryo Today"},{"key":"ref8","volume-title":"Wu, Tietz Clinical Guide to Laboratory Tests - Elsevier eBook on VitalSource, 4th Ed","author":"N W Tietz","year":"2006"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41581-018-0054-y","article-title":"Maternal and environmental risk factors for neonatal AKI and its long-term consequences","volume":"14","author":"N Perico","year":"2018","journal-title":"Nat Rev Nephrol"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2215\/CJN.03670318","article-title":"Incidence and risk factors of early onset neonatal AKI","volume":"14","author":"J R Charlton","year":"2019","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1016\/j.jpeds.2010.11.010","article-title":"Acute kidney injury post neonatal asphyxia","volume":"158","author":"A M Durkan","year":"2011","journal-title":"J Pediatr"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1186\/s12884-022-04910-w","article-title":"Fetal congenital heart disease - mode of delivery and obstetrical complications","volume":"22","author":"K Zloto","year":"2022","journal-title":"BMC Pregnancy Childbirth"},{"issue":"07","key":"ref13","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1515\/jpm-2021-0139","article-title":"Intrapartum cardiotocography in pregnancies with and without fetal CHD","volume":"50","author":"S Feduniw","year":"2022","journal-title":"J Perinat Med"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/jp.2014.104","article-title":"Mode of delivery in pregnancies complicated by major fetal congenital heart disease: a retrospective cohort study","volume":"34","author":"C A Walsh","year":"2014","journal-title":"J Perinatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"105330","DOI":"10.1016\/j.earlhumdev.2021.105330","article-title":"Non-reassuring fetal heart rate patterns: Is it a risk factor for long- term pediatric cardiovascular diseases of the offspring?","volume":"155","author":"N Leybovitz-Haleluya","year":"2021","journal-title":"Early Hum Dev"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2145-7636.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:42:14Z","timestamp":1730814134000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2145-7636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,1]]},"references-count":15,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2145-7636","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,8,1]]},"published":{"date-parts":[[2023,8,1]]}}}