{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T10:55:17Z","timestamp":1747997717344,"version":"3.28.0"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gesundheitswesen"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Kopfschmerzerkrankungen sind h\u00e4ufige Vorstellungsgr\u00fcnde in der\n                    Notaufnahme. Wichtig ist hierbei das Erkennen von potenziell\n                    gef\u00e4hrlichen Grunderkrankungen, die mit Kopfschmerzen einhergehen. Wir\n                    hypothetisierten, dass es zu einer verst\u00e4rkten Inanspruchnahme der\n                    Notaufnahme aufgrund von Kopfschmerzen kam, nachdem die ven\u00f6se Thrombose\n                    zerebraler Sinus, die oft starke Kopfschmerzen bedingt, als seltene Nebenwirkung\n                    der Impfung mit Adenovirus-Vektor-basierten Coronavirus-disease 2019\n                    (COVID-19)-Impfstoffen identifiziert und durch das Paul-Ehrlich-Institut\n                    \u00f6ffentlich kommuniziert worden war. Es erfolgte eine retrospektive\n                    Analyse der Daten von Patient*innen mit der Abschlussdiagnose einer\n                    prim\u00e4ren Kopfschmerzerkrankung oder eines nicht n\u00e4her\n                    spezifizierten Kopfschmerzes der Jahre 2019 und 2021, die sich in der Zentralen\n                    Notaufnahme der Universit\u00e4tsmedizin Mannheim vorgestellt hatten. Auf\n                    Grundlage der Daten des vom Bundesministerium f\u00fcr Gesundheit\n                    herausgegebenen Impfdashboards wurden die Kalenderwochen 14\u201330 und\n                    47\u201348 einerseits sowie 1\u201313 und 31\u201346 andererseits in\n                    eine Variable \u201eImpfepoche\u201c kategorisiert (14\u201330,\n                    47\u201348: hohe Impfaktivit\u00e4t bei bundesweit\u22653 Mio.\n                    Impfungen\/Woche; 1\u201313, 31\u201346: niedrige\n                    Impfaktivit\u00e4t bei bundesweit&lt;3 Mio. Impfungen\/Woche).\n                    Abh\u00e4ngige Variable waren die Anzahl der Vorstellungen. Mittels\n                    Poisson-Regression wurde gepr\u00fcft, ob die H\u00e4ufigkeit der\n                    Ereignisse sich als Funktion des Jahres (2019, 2021), der Impfepoche (niedrig,\n                    hoch) und einer Interaktion von Jahr und Epoche \u2013 letzteres den Effekt\n                    der Impfaktivit\u00e4t vor dem Hintergrund der Pandemie reflektierend und als\n                    Inzidenzratenverh\u00e4ltnis angegeben \u2013 darstellt. Im Vergleich zu\n                    2019 ergab sich eine \u00fcber 70%ige Zunahme von Vorstellungen\n                    aufgrund von Kopfschmerzen in Phasen hoher Impfaktivit\u00e4t im Jahr 2021\n                    (p&lt;0.001; 95%-Konfidenzintervall 1.272\u20132.316),\n                    25% der Vorstellungen im Jahr 2021 erfolgten aufgrund einer\n                    patient*innenseitig vermuteten Assoziation mit stattgehabter Impfung.\n                    Neben anderen Faktoren, welche im Rahmen der Pandemiesituation zu einer\n                    ver\u00e4nderten Vorstellungssituation f\u00fchren, m\u00f6gen die\n                    \u00f6ffentliche Informationsverbreitung und dadurch induzierte Noceboeffekte\n                    Ursachen der in unserer Analyse zutage gekommenen Unterschiede in den\n                    Vorstellungszahlen zwischen den Epochen mit unterschiedlich starker\n                    Impfaktivit\u00e4t sein. Dies illustriert die Auswirkungen der Kommunikation\n                    medizinischer Fakten und Informationen in Krisensituationen auf praktische\n                    Aspekte notfallmedizinischer Versorgung.<\/jats:p>","DOI":"10.1055\/a-2146-6286","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T00:43:02Z","timestamp":1702082582000},"page":"232-236","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiologische Untersuchung zu m\u00f6glichen Auswirkungen\n                    \u00f6ffentlicher Kommunikation im Rahmen der COVID-19-Pandemie auf\n                    Notfallvorstellungen von Kopfschmerzpatient*innen"],"prefix":"10.1055","volume":"86","author":[{"given":"Matthias","family":"Wittayer","sequence":"additional","affiliation":[{"name":"Neurologie, Universit\u00e4tsklinikum Mannheim Klinik f\u00fcr\n                    Neurologie, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesile","family":"Sandikci","sequence":"additional","affiliation":[{"name":"Neurologie, Universit\u00e4tsklinikum Mannheim Klinik f\u00fcr\n                    Neurologie, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Ebert","sequence":"additional","affiliation":[{"name":"Neurologie, Universit\u00e4tsklinikum Mannheim Klinik f\u00fcr\n                    Neurologie, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Koehler","sequence":"additional","affiliation":[{"name":"Neurologie, Universit\u00e4tsklinikum Mannheim Klinik f\u00fcr\n                    Neurologie, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Szabo","sequence":"additional","affiliation":[{"name":"Neurologie, Universit\u00e4tsklinikum Mannheim Klinik f\u00fcr\n                    Neurologie, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin","family":"Hoyer","sequence":"additional","affiliation":[{"name":"Neurologie, Universit\u00e4tsklinikum Mannheim Klinik f\u00fcr\n                    Neurologie, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1468-2982.2006.01093.x","article-title":"Headache in United States emergency departments: demographics, work-up and\n                    frequency of pathological diagnoses","volume":"26","author":"J N Goldstein","year":"2006","journal-title":"Cephalalgia"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1001\/jamaneurol.2021.3619","article-title":"Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis\n                    in SARS-CoV-2 Vaccine-Induced 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and territories in 2020 due to the COVID-19 pandemic","volume":"398","author":"Collaborators C-MD","year":"2021","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s40122-021-00296-3","article-title":"Headache Attributed to Vaccination Against COVID-19 (Coronavirus SARS-CoV-2)\n                    with the ChAdOx1 nCoV-19 (AZD1222) Vaccine: A Multicenter Observational Cohort\n                    Study","volume":"10","author":"C H Gobel","year":"2021","journal-title":"Pain Ther"}],"container-title":["Das 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