{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:14:20Z","timestamp":1767917660448,"version":"3.49.0"},"reference-count":84,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die feline infekti\u00f6se Peritonitis (FIP) ist eine der h\u00e4ufigsten Infektionskrankheiten bei Katzen und verl\u00e4uft unbehandelt t\u00f6dlich. Bisher gibt es in Deutschland keine legal verf\u00fcgbare wirksame Therapie. Therapieoptionen reichen von der symptomatischen Therapie (z.\u2009B. Glukokortikoide, Propentofyllin) \u00fcber immunmodulatorische Ans\u00e4tze (z.\u2009B. Interferone, Polyprenyl-Immunstimulanz) bis hin zur antiviralen Therapie mit einem Protease-Inhibitor (z.\u2009B. GC376) oder Nukleosid-Analoga (z.\u2009B. GS-441524, Remdesivir). Die symptomatische Therapie f\u00fchrt nicht zur Heilung der FIP, sondern nur zu einer kurzzeitigen Verbesserung der klinischen Symptome bei wenigen Katzen. Auch eine immunmodulatorische Therapie stellte sich als wenig erfolgversprechend heraus. Die antiviralen Medikamente GS-441524 und GC376 waren in mehreren Studien hochwirksam und konnten das Leben vieler an FIP erkrankten Katzen retten. Beide Wirkstoffe sind aktuell in Deutschland nicht zugelassen und k\u00f6nnen von Tier\u00e4rzten nicht legal angewendet werden. Katzen d\u00fcrfen aktuell nur in wenigen L\u00e4ndern (z. B. Gro\u00dfbritannien und Australien) legal mit GS-441524 therapiert werden. GS-441524 wird daher von Katzenbesitzern in vielen anderen L\u00e4ndern \u00fcber den Schwarzmarkt bestellt und in Eigenregie angewendet. Dieser Artikel gibt eine \u00dcbersicht \u00fcber verf\u00fcgbare Therapieoptionen und einen Ausblick zur legalen Anwendung wirksamer antiviraler Medikamente.<\/jats:p>","DOI":"10.1055\/a-2147-3999","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T23:30:31Z","timestamp":1699918231000},"page":"351-360.","source":"Crossref","is-referenced-by-count":1,"title":["Optionen zur Therapie der felinen infekti\u00f6sen Peritonitis \u2013 fr\u00fcher und heute"],"prefix":"10.1055","volume":"51","author":[{"given":"Daniela","family":"Krentz","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Felten","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1136\/vr.151.17.497","article-title":"Kitten mortality in the United Kingdom: a retrospective analysis of 274 histopathological examinations (1986 to 2000)","volume":"151","author":"T A Cave","year":"2002","journal-title":"Vet 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